Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Francella J. Otero"'
Autor:
Luke A. Bourner, Linda A. Chung, Haiyan Long, Anne F. McGettrick, Junpeng Xiao, Kenneth Roth, Jade D. Bailey, Marie Strickland, Bo Tan, Jason Cunningham, Barry Lutzke, James McGee, Francella J. Otero, David C. Gemperline, Lin Zhang, Ying C. Wang, Michael J. Chalmers, Chiao-Wen Yang, Jesus A. Gutierrez, Luke A.J. O’Neill, Frank C. Dorsey
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114570- (2024)
Summary: A wide variety of electrophilic derivatives of itaconate, the Kreb’s cycle-derived metabolite, are immunomodulatory, yet these derivatives have overlapping and sometimes contradictory activities. Therefore, we generated a genetic system to
Externí odkaz:
https://doaj.org/article/55ca952d3ac049d4a45d8028c026aed2
Autor:
Xiang-Lei Yang, Eleni Tzima, Mili Kapoor, Christopher A. Myers, Rajesh Belani, Jiann Kae Luo, Paul Schimmel, Quansheng Zhou, Dong-Er Zhang, Francella J. Otero, Jianming Liu, Alison Bates
Publikováno v:
Journal of Biological Chemistry. 283:2070-2077
In mammalian cells, specific aminoacyl-transfer RNA (tRNA) synthetases have cytokine functions that require interactions with partners outside of the translation apparatus. Little is known about these interactions and how they facilitate expanded fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461c0d14166c081c45878f39d3bbed0b
https://doi.org/10.1074/jbc.m706028200
https://doi.org/10.1074/jbc.m706028200
Autor:
Bonnie M. Slike, Mili Kapoor, Xiang-Lei Yang, David A. Cheresh, Francella J. Otero, Paul Schimmel, Ricardo F. Frausto, Alison Bates, Karla L. Ewalt, Hiro Tsuruta
Publikováno v:
Chemistry & Biology. 14(12):1323-1333
SummaryDisease-causing mutations occur in genes for aminoacyl tRNA synthetases. That some mutations are dominant suggests a gain of function. Native tRNA synthetases, such as tyrosyl-tRNA synthetase (TyrRS) and tryptophanyl-tRNA synthetase, catalyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e250729d99646ec8b832959bd877fae4
Autor:
Min Guo, Xiang-Lei Yang, Francella J. Otero, Karla L. Ewalt, Duncan E. McRee, Mili Kapoor, Robert J. Skene, Paul Schimmel
Publikováno v:
Structure. 15(7):793-805
Higher eukaryote tRNA synthetases have expanded functions with roles in the assembly of biological systems. New functions come from enlarged, more differentiated structures that were adapted to fit with the essential aminoacylation function. How thos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809be7e5f13344bd63d447b9f6e4dd26
Autor:
Manal A. Swairjo, Xiang-Lei Yang, Caroline Köhrer, Karla L. Ewalt, Paul Schimmel, Jianming Liu, Uttam L. RajBhandary, Duncan E. McRee, Francella J. Otero, Robert J. Skene
Publikováno v:
The EMBO Journal. 25:2919-2929
Aminoacylation of tRNA is the first step of protein synthesis. Here, we report the co-crystal structure of human tryptophanyl-tRNA synthetase and tRNATrp. This enzyme is reported to interact directly with elongation factor 1alpha, which carries charg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10556b26460b49892fdfae69446033d
https://doi.org/10.1038/sj.emboj.7601154
https://doi.org/10.1038/sj.emboj.7601154
Autor:
Karla L. Ewalt, Francella J. Otero, Bonnie M. Slike, Xiang-Lei Yang, Paul Schimmel, Jianming Liu
Publikováno v:
Biochemistry. 44:4216-4221
In cellular environments, coupled hydrolytic reactions are used to force efficient product formation in enzyme-catalyzed reactions. In the first step of protein synthesis, aminoacyl-tRNA synthetases react with amino acid and ATP to form an enzyme-bou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f609e4eee0111ccd12b4cdd1c6625060
https://doi.org/10.1021/bi048116l
https://doi.org/10.1021/bi048116l
Autor:
Francella J. Otero, Xiang-Lei Yang, Paul Schimmel, Duncan E. McRee, Robert J. Skene, Lluís Ribas de Pouplana
Early forms of the genetic code likely generated “statistical” proteins, with similar side chains occupying the same sequence positions at different ratios. In this scenario, groups of related side chains were treated by aminoacyl-tRNA synthetase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f18af1e4d203253744c6e91ac36b33
https://europepmc.org/articles/PMC307575/
https://europepmc.org/articles/PMC307575/
Autor:
Martha A. Lovato, Manal A. Swairjo, Robert J. Skene, Francella J. Otero, Lluís Ribas de Pouplana, Xiang-Lei Yang, Paul Schimmel, Duncan E. McRee
Publikováno v:
Molecular cell. 13(6)
Early work on aminoacylation of alanine-specific tRNA (tRNA(Ala)) by alanyl-tRNA synthetase (AlaRS) gave rise to the concept of an early "second genetic code" imbedded in the acceptor stems of tRNAs. A single conserved and position-specific G:U base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2fd851f20e19a44e75e384f2f8bdf6
https://pubmed.ncbi.nlm.nih.gov/15053876
https://pubmed.ncbi.nlm.nih.gov/15053876
Autor:
Karla L. Ewalt, Martin Friedlander, Karen Kinder, Atsushi Otani, Paul Schimmel, Francella J. Otero
Publikováno v:
Nature medicine. 8(9)
Adult bone marrow (BM) contains cells capable of differentiating along hematopoietic (Lin(+)) or non-hematopoietic (Lin(-)) lineages. Lin(-) hematopoietic stem cells (HSCs) have recently been shown to contain a population of endothelial precursor cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9727d19a1b963fb54cef441bf6998b3c
https://pubmed.ncbi.nlm.nih.gov/12205451
https://pubmed.ncbi.nlm.nih.gov/12205451
Publikováno v:
Chemistry & Biology. (5):531-539
SummaryAminoacyl tRNA synthetases are known for catalysis of aminoacylation. Significantly, some mammalian synthetases developed cytokine functions possibly linked to disease-causing mutations in tRNA synthetases. Not understood is how epitopes for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b7c3dd2118e187951eee686e22537f