Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

Autor: Stefano Woltersdorf, Thomas Duflot, Christophe Morisseau, Victor Hernandez-Olmos, Ewgenij Proschak, Apirat Chaikuad, Franca-M Klingler, Sandra K. Wittmann, Felix Knöll, Dieter Steinhilber, Jan S. Kramer, Felix F Lillich, Angelo Sala, Kerstin Hiesinger, Daniel Merk, Sylvain Fraineau, Jeremy Bellien, Bruce D. Hammock, Jan Heering, Steffen Brunst, Stefan Knapp, G. Enrico Rovati, Julie Rondeaux, Denys Pogoryelov, Carola Buccellati, Matthieu Leuillier

Publikováno v: J Med Chem
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2019, 62 (18), pp.8443-8460. ⟨10.1021/acs.jmedchem.9b00445⟩
Journal of medicinal chemistry, vol 62, iss 18
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (18), pp.8443-8460. ⟨10.1021/acs.jmedchem.9b00445⟩

International audience; The emerging pharmacological target soluble epoxide hydrolase (sEH) is a bifunctional enzyme exhibiting two different catalytic activities that are located in two distinct domains. Although the physiological role of the C-term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b07e7660f038c7c67a88ec36232ea6
https://doi.org/10.1021/acs.jmedchem.9b00445

Correction to ApprovedDrugs Containing Thiols as Inhibitors of Metallo-β-lactamases:Strategy To Combat Multidrug-Resistant Bacteria.

Autor: Franca-M. Klingler, ThomasA. Wichelhaus, Denia Frank, Jenifer Cuesta-Bernal, Jasmin El-Delik, H. Florian Müller, Hanno Sjuts, Stephan Göttig, Arno Koenigs, Klaas M. Pos, Denys Pogoryelov, Ewgenij Proschak

Publikováno v: Journal of Medicinal Chemistry; Aug2015, Vol. 58 Issue 15, p6320-6320, 1p