Výsledky vyhledávání - "Franca Orsini"

Akademický článek

SUMO2 rescues neuronal and glial cells from the toxicity of P301L Tau mutant

Autor: Franca Orsini, Rosaria Pascente, Annacarla Martucci, Sara Palacino, Paul Fraser, Ottavio Arancio, Luana Fioriti

Publikováno v: Frontiers in Cellular Neuroscience, Vol 18 (2024)

IntroductionAbnormal intracellular accumulation of Tau aggregates is a hallmark of Alzheimer’s disease (AD) and other Tauopathies, such as Frontotemporal dementia (FTD). Tau deposits primarily affect neurons, but evidence indicates that glial cells

Externí odkaz: https://doaj.org/article/e7a4188a42c64c888ee8ddc79278f7bb

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A Combined Cell-Worm Approach to Search for Compounds Counteracting the Toxicity of Tau Oligomers In Vivo

Autor: Carmina Natale, Maria Monica Barzago, Luca Colnaghi, Ada De Luigi, Franca Orsini, Luana Fioriti, Luisa Diomede

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11277

A clear relationship between the tau assemblies and toxicity has still to be established. To correlate the tau conformation with its proteotoxic effect in vivo, we developed an innovative cell-worm-based approach. HEK293 cells expressing tau P301L un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72f53771089c9169eace732dea4b005
https://pubmed.ncbi.nlm.nih.gov/36232578

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Mannose-binding lectin has a direct deleterious effect on ischemic brain microvascular endothelial cells

Autor: Maria Grazia De Simoni, Adriana Zanetti, Stefano Fumagalli, Carlo Perego, Franca Orsini, Laura Neglia

Publikováno v: Journal of Cerebral Blood Flow & Metabolism

Mannose-binding lectin (MBL), an initiator of the lectin pathway, is detrimental in ischemic stroke. MBL deposition on the ischemic endothelium indicates the beginning of its actions, but downstream mechanisms are not clear yet. We investigated MBL i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0361a210543ddb3dfe767f3a17dfc6
http://europepmc.org/articles/PMC7370363

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Human brain trauma severity is associated with lectin complement pathway activation

Autor: Maria Grazia De Simoni, Fabrizio Ortolano, Nino Stocchetti, Daiana De Blasio, Franca Orsini, Stefano Fumagalli, Elisa R. Zanier, Luca Longhi, Carlo Perego, Edoardo Picetti, Marco Locatelli, Peter Garred, Laura Neglia

Publikováno v: Journal of Cerebral Blood Flow & Metabolism
De Blasio, D, Fumagalli, S, Orsini, F, Neglia, L, Perego, C, Ortolano, F, Zanier, E R, Picetti, E, Locatelli, M, Stocchetti, N, Longhi, L, Garred, P & De Simoni, M 2019, ' Human brain trauma severity is associated with lectin complement pathway activation ', Journal of Cerebral Blood Flow and Metabolism, vol. 39, no. 5, pp. 794-807 . https://doi.org/10.1177/0271678X18758881

We explored the involvement of the lectin pathway of complement in post-traumatic brain injury (TBI) pathophysiology in humans. Brain samples were obtained from 28 patients who had undergone therapeutic contusion removal, within 12 h (early) or from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4d75c8ad689a8e3f6d0feb3514cc96
http://europepmc.org/articles/PMC6501516

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A New Surface Plasmon Resonance Assay for In Vitro Screening of Mannose-Binding Lectin Inhibitors

Autor: Matteo Stravalaci, Marco Gobbi, Alessandro Palmioli, Anna Bernardi, Carlo Perego, Daiana De Blasio, Franca Orsini, Maria Grazia De Simoni, Giulio Goti

Publikováno v: Europe PubMed Central

Mannose-binding lectin (MBL) is a circulating protein that acts as a soluble pattern recognition molecule of the innate immunity. It binds to carbohydrate patterns on the surface of pathogens or of altered self-cells, with activation of the lectin pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a62bb03e348d2dbd49e878572069c8d
https://doi.org/10.1177/1087057116637563

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Pharmacological inhibition of mannose-binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury

Autor: Luca Longhi, Alessandro Palmioli, Marco Gobbi, Stefano Fumagalli, Gloria Vegliante, Maria Grazia De Simoni, Elisa R. Zanier, Franca Orsini, Matteo Stravalaci, Anna Bernardi, Daiana De Blasio

Publikováno v: Europe PubMed Central

Mannose-binding lectin is present in the contusion area of traumatic brain-injured patients and in that of traumatic brain-injured mice, where mannose-binding lectin-C exceeds mannose-binding lectin-A. The reduced susceptibility to traumatic brain in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58750d20ea22df68f476f9c8d294c8ff
https://doi.org/10.1177/0271678x16647397

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Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α

Autor: Nikolett Lénárt, Eszter Császár, Krisztina Tóth, Maria Grazia De Simoni, Stefano Fumagalli, Rosalia Zangari, Franca Orsini, Adam Denes, Daiana De Blasio

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology

Supplemental Digital Content is available in the text.
Objective— Circulating complement factors are activated by tissue damage and contribute to acute brain injury. The deposition of MBL (mannose-binding lectin), one of the initiators of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc1961270cbb10bd430a40e2235cf9e
https://pubmed.ncbi.nlm.nih.gov/30354247

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Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1

Autor: Maria Grazia De Simoni, Teizo Fujita, W. Jason Cummings, Gregory A. Demopulos, Franca Orsini, Elvina Chrysanthou, Wilhelm J. Schwaeble, Minoru Takahashi, Thomas Dudler

Publikováno v: Journal of Neuroinflammation

Background Complement activation via the lectin activation pathway (LP) has been identified as the key mechanism behind post-ischemic tissue inflammation causing ischemia-reperfusion injury (IRI) which can significantly impact the clinical outcome of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b76a830c3e3ef06f596fb4d7b3bf52
https://doi.org/10.1186/s12974-016-0684-6

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Proteomic analysis of mouse brain cortex identifies metabolic down-regulation as a general feature of ischemic pre-conditioning

Autor: Roberta Pastorelli, Roberto Fanelli, Maria Grazia De Simoni, Luisa Airoldi, Giacomo Scornavacca, Raffaella Gesuete, Franca Orsini

Publikováno v: Journal of Neurochemistry. 122:1219-1229

The molecular mechanisms that lead to ischemic pre-conditioning are not completely understood, and proteins are important players. We compared the mouse brain cortex proteome from different ischemia sets: transient (7 min) middle cerebral artery occl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44a5a74fcf48330e74c19dc682fa6651
https://doi.org/10.1111/j.1471-4159.2012.07874.x

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Glial Cells Drive Preconditioning-Induced Blood-Brain Barrier Protection

Autor: Mária A. Deli, Diego Albani, Raffaella Gesuete, Elisa R. Zanier, Franca Orsini, Gianfranco Bazzoni, Maria Grazia De Simoni

Publikováno v: Stroke. 42:1445-1453

Background and Purpose— The cerebrovascular contribution to ischemic preconditioning (IPC) has been scarcely explored. Using in vivo and in vitro approaches, we investigated the involvement of the blood-brain barrier and the role of its cellular co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453c9483efff723fba80abac44b92c28
https://doi.org/10.1161/strokeaha.110.603266

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