Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Franca Mazzucchelli"'
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Aging-Dependent Large Accumulation of Point Mutations in the Human mtDNA Control Region for Replication
Autor: Giuseppe Attardi, Franca Mazzucchelli, Guglielmo Scarlato, Yuichi Michikawa, Nereo Bresolin
Publikováno v: Science. 286:774-779
Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. However, this idea has been difficult to reconcile with the small fraction of mtDNA so far found to be altered. Here, examination of mtDNA reveal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8366e17ad5e88a776351aba3c4da866
https://doi.org/10.1126/science.286.5440.774
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3
Clinical and molecular studies of 73 Italian families with autosomal dominant cerebellar ataxia type I: SCA1 and SCA2 are the most common genotypes
Autor: Barbara Castellotti, Floriano Girotti, Maria Concetta Riggio, Cinzia Gellera, V. Pietrini, Franca Mazzucchelli, Antonella Antonelli, S. Di Donato, Caterina Mariotti, Davide Pareyson
Publikováno v: Journal of Neurology. 246:389-393
We clinically and genetically evaluated 73 Italian families with autosomal dominant cerebellar ataxia (ADCA) type I. Spinocerebellar ataxia (SCA) type 1 was the most common genotype (SCA1), accounting for 41% of cases (30 families), SCA2 was slightly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96521567837120f20b31aa07c7289aec
https://doi.org/10.1007/s004150050369
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4
Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts
Autor: Franca Mazzucchelli, Nereo Bresolin, Marilena Greco, Sergio Papa, Gaetano Villani, Giuseppe Attardi
Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17(12)
An extensive analysis has been carried out of mitochondrial biochemical and bioenergetic properties of fibroblasts, mostly skin-derived, from a large group of subjects ranging in age between 20 wk fetal and 103 yr. A striking age-related change obser
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b999ea79a6fc5ca15f69a0517325f6a
https://pubmed.ncbi.nlm.nih.gov/12958183
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5
Very late onset Friedreich's ataxia without cardiomyopathy is associated with limited GAA expansion in the X25 gene
Autor: Franca Mazzucchelli, Stefano Di Donato, Massimo Pandolfo, Boris Zappacosta, Davide Pareyson, Barbara Castellotti, Cinzia Gellera
Publikováno v: Scopus-Elsevier
Molecular analysis of spinocerebellar ataxias revealed a pathologic GAA expansion in the gene encoding frataxin in six adult patients from three families. These patients, carrying expanded alleles in the low-range size, had an exceptionally late onse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23869d89d7816947ae482452d850f7f
https://pubmed.ncbi.nlm.nih.gov/9339708
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6
Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells
Autor: Franca Mazzucchelli, Guglielmo Scarlato, Kenneth A. Laderman, Giuseppe Attardi, Nereo Bresolin, James R. Penny
Publikováno v: The Journal of biological chemistry. 271(27)
To investigate the role that aging-dependent accumulation of mitochondrial DNA (mtDNA) mutations plays in the senescence processes, mitochondria from fibroblasts of 21 normal human individuals between 20 weeks (fetal) and 103 years of age were introd
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6061dd90e7e2df7e8a7c12ba6c683c0
https://pubmed.ncbi.nlm.nih.gov/8663253
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7
Development of dopaminergic neurons in the human mesencephalon and in vitro effects of basic fibroblast growth factor treatment
Autor: Vincenzo Silani, Donatella Mariani, Giorgio Pardi, C. Ghezzi, Mauro Buscaglia, Guglielmo Scarlato, Franca M. Donato, Franca Mazzucchelli
Publikováno v: Experimental neurology. 128(1)
The origin and development of the mesencephalic dopaminergic (mesDA) neurons within the substantia nigra were characterized in human embryos from Postconception (PC) Week 5.0 to 12.0. Tyrosine hydroxylase (TH) immunoreactive cells were first demonstr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c3fd5dd3017c9bab944188d4031b9f
https://pubmed.ncbi.nlm.nih.gov/7915238
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