Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Franc Gubenšek"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1702:217-225
The molecular mechanism of action of presynaptically toxic secreted phospholipases A2 (sPLA2s) isolated from snake venoms is not completely understood. It has been proposed that the positive charge in the h-structure region is important for their tox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a368ea517dc5a6389387b3fb1a86de06
https://doi.org/10.1016/j.bbapap.2004.09.002
https://doi.org/10.1016/j.bbapap.2004.09.002
Autor:
Franc Gubenšek, Igor Križaj, Jošt Kuret, Mateja Poljšak-Prijatelj, Alenka Čopič, Jernej Šribar, Uros Logonder
Publikováno v:
FEBS Letters. 553:309-314
Ammodytoxin is a presynaptically neurotoxic (β-neurotoxic) snake venom secretory phospholipase A2 (sPLA2). We detected a 25 kDa protein which binds the toxin with very high affinity (R25) in porcine cerebral cortex [Vucemilo et al., Biochem. Biophys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c5079030cb56f30a051453991fc3d9f
https://doi.org/10.1016/s0014-5793(03)01035-4
https://doi.org/10.1016/s0014-5793(03)01035-4
Autor:
Jože Pungerčar, Igor Križaj, Franc Gubenšek, Jernej Šribar, Petra Prijatelj, Gabriela Ivanovski
Publikováno v:
European Journal of Biochemistry. 270:3018-3025
The molecular mechanism of the presynaptic neurotoxicity of snake venom phospholipases A2 (PLA2s) is not yet fully elucidated. Recently, new high-affinity binding proteins for PLA2 toxins have been discovered, including the important intracellular Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86d7e3d9db02dfbb84c06849db1e1dc0
https://doi.org/10.1046/j.1432-1033.2003.03679.x
https://doi.org/10.1046/j.1432-1033.2003.03679.x
Publikováno v:
Toxicon. 41:509-517
Crotoxin, a potent neurotoxin from the South American rattlesnake Crotalus durissus terrificus, is a heterodimeric phospholipase A(2) (EC 3.1.1.4), which blocks the release of acetylcholine from peripheral neurons. We previously have suggested the ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4dbbb8c21e33f7835da5914f8ffba3
https://doi.org/10.1016/s0041-0101(02)00394-x
https://doi.org/10.1016/s0041-0101(02)00394-x
Publikováno v:
Toxicon. 40:543-549
The neurotoxic activity of ammodytoxin A (AtxA), a phospholipase A2 from Vipera ammodytes ammodytes venom, has been investigated by protein engineering. With the aim of obtaining AtxA as a non-fused protein in the bacterial cytoplasm and avoiding pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b609a645d2aeaf5b223da715f8ed28f
https://doi.org/10.1016/s0041-0101(01)00250-1
https://doi.org/10.1016/s0041-0101(01)00250-1
Publikováno v:
Biochemical Journal. 363:353-358
Ammodytoxins (Atxs) are group II phospholipases A(2) (PLA(2)s) with presynaptic toxicity from venom of the snake Vipera ammodytes ammodytes. The molecular basis of their neurotoxicity, and that of similar PLA(2) toxins, is still to be explained. To a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ed50f606167275e40cb918a887c360
https://doi.org/10.1042/bj3630353
https://doi.org/10.1042/bj3630353
Publikováno v:
bchm. 382:867-870
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b29bd1c8e786307304b864dd448ecc27
https://doi.org/10.1515/bchm.2001.382.5.867
https://doi.org/10.1515/bchm.2001.382.5.867
Publikováno v:
Biochemical Journal. 352:251-255
The positive charge concentrated at the C-terminal region of ammodytoxin (Atx) A, which is involved in presynaptic toxicity, has been reversed. A six-site mutant of AtxA (K108N/K111N/K127T/K128E/E129T/K132E, where K108N = Lys108 → Asn etc.) was pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29eeb97f83dab8cc47136c06bd8c9a9b
https://doi.org/10.1042/bj3520251
https://doi.org/10.1042/bj3520251
Autor:
Gregor Anderluh, Ariana Barlič, Zdravko Podlesek, Gianfranco Menestrina, Peter Maček, Franc Gubenšek, Alioša Bavec, Blaž Cigiš, Matjaž Zorko, Alenka Čopič, Nataša Vučemilo, Igor Križaj, Gabriela Ivanovski, Jože Pungerčar, M. Jeras, M.-M. Tongio, Tea Lanišnik Rižner, Gabriele Moeller, Hubert H. Thole, Marija Žakelj-Mavrič, Jerzy Adamski, Petra Malovrh, C. Montecucco, E. Papini, M. De Bernard, M. Molinari, B. Satin, V. Pelicic, M. Pogačar, T. Lanišnik Rižner, M. Zorko, M. Žakelj-Mavrič, Boris Rogelj, Anka Ritonja, Tatjana Popovič, Jože Brzin, Jerica Rozman, Jure Stojan, Robert Kuhelj, Vito Turk, Boris Turk, Borut Štrukelj, Kristina Gruden, Brigita Lenarčič, Dirk Bosch, Willem J. Stiekema, Maarten A. Jongsma, Vera Župunski, Dušan Kordiš
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 439:r124-r127
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a6d2b18d04e3bb809f1a24418a398eb
https://doi.org/10.1007/s004240000115
https://doi.org/10.1007/s004240000115
Publikováno v:
Biochemical Journal. 341:139-145
Ammodytoxins (Atxs) A, B and C are basic phospholipase A2s from Vipera ammodytes ammodytes snake venom, and they exhibit presynaptic toxicity. The most toxic is AtxA, followed by AtxC, its naturally occurring F124 → I/K128 → E mutant, which is 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c78fd3958c0953e09a84aa4872e898ed
https://doi.org/10.1042/bj3410139
https://doi.org/10.1042/bj3410139