Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Fran Su"'
Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations
Autor:
Elizaveta Besedina, Fran Supek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Cancer driver genes can undergo positive selection for various types of genetic alterations, including gain-of-function or loss-of-function mutations and copy number alterations (CNA). We investigated the landscape of different types of alte
Externí odkaz:
https://doaj.org/article/f1ad9dcb6dde486bae5214b2ba28ab1e
Publikováno v:
Edukasia, Vol 5, Iss 1 (2024)
The aim of the study is to describe students’ visual thinking process in solving third dimensional problems. This research was descriptive study with qualitative approach. Two girls students with the higher rank in mathematics’ test and represent
Externí odkaz:
https://doaj.org/article/9217ea3036a146fc971fe51e66e39a48
Autor:
Alison M Hutchinson, Claudia Meyer, De Villiers Smit, Judy A Lowthian, Amber Mills, Fran Sutherland, Leanne Boyd, Michael Rose, Ahsan Saleem, Arti Appannah, Fleur O'Keefe
Publikováno v:
BMJ Open, Vol 14, Iss 5 (2024)
Objectives Researchers face numerous challenges when recruiting participants for health and social care research. This study reports on the challenges faced recruiting older adults for Being Your Best, a co-designed holistic intervention to manage an
Externí odkaz:
https://doaj.org/article/4d09b03a53ad4b7081c4ccdb10c89996
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Ionizing radiation is known to be DNA damaging and mutagenic, however less is known about which mutational footprints result from exposures of human cells to different types of radiation. We were interested in the mutagenic effects of partic
Externí odkaz:
https://doaj.org/article/a1846ecdc04a47d6a298d2a4c0eaa79b
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-25 (2023)
Abstract Background TP53 is a master tumor suppressor gene, mutated in approximately half of all human cancers. Given the many regulatory roles of the corresponding p53 protein, it is possible to infer loss of p53 activity – which may occur due to
Externí odkaz:
https://doaj.org/article/0e83e71c9c774af0b871e2049e79e55c
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Toxicity of CRISPR/Cas9 induced DNA breaks depends on their repair mechanism, and on the chromatin environment at the cut site. Here the authors show that edits in active genes or regulatory elements can incur a higher toxicity via a TP53-dependent m
Externí odkaz:
https://doaj.org/article/ed5a589aa6d54b0d868f35820914072d
Autor:
Mischan Vali-Pour, Solip Park, Jose Espinosa-Carrasco, Daniel Ortiz-Martínez, Ben Lehner, Fran Supek
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Abstract Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types of somatic mutation vary across individuals, but relatively few inherited influences on mutation processes are known. We perf
Externí odkaz:
https://doaj.org/article/22847fd38e7c4b5e9fbc949293592c93
Autor:
Robinson Simon P, Heike S. Radeke, Kelley Hanson, Yu Ming, Ajay Purohit, Mikhail Kagan, Padmaja Yalamanchili, Fran Su, Michael Azure, Megan Hayes, Richard Benetti, David Casebier, Mary Guaraldi
Publikováno v:
Journal of Medicinal Chemistry. 51:2954-2970
A series of fluorinated pyridazinone derivatives with IC50 values ranging from 8 to 4000 nM for the mitochondrial complex 1 (MC1) have been prepared. Structure-activity relationship (SAR) assessment indicated preference of the fluorine label to be in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85efb56bb5eca380424d546c55bb8f18
https://doi.org/10.1021/jm701443n
https://doi.org/10.1021/jm701443n
Autor:
David S. Casebier, Mikhail Kagan, Simon P. Robinson, Richard Benetti, Padmaja Yalamanchilli, Ajay Purohit, Douglas D. Dischino, Megan Hayes, Michael Azure, Mary Guaraldi, Fran Su, Ming Yu, Mahesh Mistry
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4882-4885
Several quinazoline derivatives were made as mitochondrial complex 1 inhibitors. Compound 4 showed an IC(50) of 11.3 nM and was the most potent compound of this series. The (18)F analog of 4, [(18)F] 4, was injected in the rat and showed high and rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392b543a4ae0d98238f90bf6ea10a074
https://doi.org/10.1016/j.bmcl.2007.06.043
https://doi.org/10.1016/j.bmcl.2007.06.043
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Mutational signatures can reveal the impact of mutagenic processes in cancer, including exposure to therapy. Here, the authors develop an approach that can accurately predict drug responses in cancer using mutational signatures while simultaneously c
Externí odkaz:
https://doaj.org/article/c4494999752b493eb8458079fa2349e1