Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Françoise Wendling"'
Autor:
Françoise Wendling, Francesco Paoletti, Hedia Chagraoui, Anna Rita Migliaccio, Alessandro M. Vannucchi
Publikováno v:
Seminars in Oncology. 32:365-372
The primary genetic lesion(s), as well as the biological processes responsible for the typical structural changes of the bone marrow microenvironment in idiopathic myelofibrosis, are still poorly understood, although a central role in disease pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086c0c73ff9fa2e57dfb87103fe1eed3
https://doi.org/10.1053/j.seminoncol.2005.04.008
https://doi.org/10.1053/j.seminoncol.2005.04.008
Autor:
Emiko Komura, Theodore Yun, Hedia Chagraoui, Françoise Wendling, Micheline Tulliez, Nathalie Lassau, Tarek Smayra, Stéphane Giraudier, William Vainchenker
Publikováno v:
Blood. 101:2983-2989
Myelofibrosis and osteosclerosis are prominent features arising in mice overexpressing thrombopoietin (TPO). The pivotal role of transforming growth factor β1 (TGF-β1) in the pathogenesis of myelofibrosis has been documented, but the mechanisms med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7851fdb24cabfd0d26882fa0ff5b4d4c
https://doi.org/10.1182/blood-2002-09-2839
https://doi.org/10.1182/blood-2002-09-2839
Autor:
Françoise Wendling, Françoise Moreau-Gachelin, Nicole Denis, William Vainchenker, Erwan Le Scolan, Stéphane Barnache, Micheline Tulliez
Publikováno v:
Oncogene. 20:5484-5492
Activation of the spi-1/PU.1 proto-oncogene and loss of p53 function are genetic alterations associated with the emergence of Friend malignant erythroleukemic cells. To address the role of p53 during erythroleukemogenesis, spi-1 transgenic mice (spi-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fc1f1423f4f74f7a248b2e11f3026f
https://doi.org/10.1038/sj.onc.1204708
https://doi.org/10.1038/sj.onc.1204708
Autor:
Elisabeth M. Cramer, Arnaud Drouin, Alain Schmitt, Françoise Wendling, Josette Guichard, Hélène Jouault
Publikováno v:
Blood. 96:1342-1347
Idiopathic myelofibrosis (MF) is a myeloproliferative syndrome characterized by an increase in bone marrow collagen. Megakaryocytes (Mks), which store growth factors in their alpha granules, are known to be involved in the pathogenesis of MF. Previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88982a7d144de71f6db11c81bc1f793a
https://doi.org/10.1182/blood.v96.4.1342
https://doi.org/10.1182/blood.v96.4.1342
Publikováno v:
Europe PubMed Central
Thrombopoietin (TPO) is a hematopoietic growth factor that regulates megakaryocytopoiesis and platelet production through binding to its receptor, Mpl, encoded by the c-mpl proto-oncogene. Circulating levels of TPO are regulated by receptor-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284dae0f81454ca3673c849129b0f298
https://doi.org/10.1182/blood.v93.9.2859
https://doi.org/10.1182/blood.v93.9.2859
Autor:
Nicole Casadevall, Françoise Wendling, Stéphane Giraudier, Jean-Pierre Le Couedic, André Katz, William Vainchenker, Anne Laure Taksin, Najet Debili, Aline Massé, Isabelle Dusanter-Fourt
Publikováno v:
ResearcherID
Essential thrombocythemia (ET) and idiopathic myelofibrosis (PMF) are two myeloproliferative diseases characterized by a marked megakaryocytic (MK) involvement. The pathogenesis of these two diseases is unknown. Recently it has been shown that overex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45aa57cbb85949ca25e1db3f3f6862e0
https://doi.org/10.1182/blood.v93.1.125
https://doi.org/10.1182/blood.v93.1.125
Publikováno v:
Biotherapy. 10:269-277
Thrombopoietin (TPO) or Mpl ligand is the primary physiological regulator of platelet production. This cytokine is the most potent stimulator of the proliferation and differentiation of MK progenitor and precursor cells in vitro. It also acts additiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e0db087c784cdb767a06555e2ea73f
https://doi.org/10.1007/bf02678547
https://doi.org/10.1007/bf02678547
Autor:
Elisabeth M. Cramer, Josette Guichard, Samuel A. Burstein, Françoise Wendling, Karine Cohen-Solal, Jean-Luc Villeval, William Vainchenker, Micheline Tulliez, Stéphane Giraudier
Publikováno v:
Blood. 90:4369-4383
To evaluate the effects of long-term, high-dose exposure to thrombopoietin (TPO), lethally irradiated mice were grafted with bone marrow cells infected with a retrovirus carrying the murine TPO cDNA. Mice were studied for 10 months after transplantat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d372d8bdc016a13ed40b71db2c5e351
https://doi.org/10.1182/blood.v90.11.4369
https://doi.org/10.1182/blood.v90.11.4369
Autor:
Zhong-Chao Han, Françoise Wendling
Publikováno v:
Baillière's Clinical Haematology. 10:29-45
The recently cloned physiological regulator of megakaryocytopoiesis, known as Mpl ligand, thrombopoietin (TPO), megakaryocyte growth and development factor (MGDF) or megapoietin, is undergoing preclinical and clinical trials. This factor is an extrem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ec61f58cc6dbd9de6702e699549a85a
https://doi.org/10.1016/s0950-3536(97)80049-2
https://doi.org/10.1016/s0950-3536(97)80049-2
Autor:
Molina T, Armand Tavitian, P Briand, M Titeux, Françoise Wendling, W Vainchenker, Nicole Denis, Françoise Moreau-Gachelin, G Grimber
Publikováno v:
Molecular and Cellular Biology. 16:2453-2463
Insertional mutagenesis of the spi-1 gene is associated with the emergence of malignant proerythroblasts during Friend virus-induced acute erythroleukemia. To determine the role of spi-1/PU.1 in the genesis of leukemia, we generated spi-1 transgenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ca5c9b01275ad5146ddeed8a79bf02
https://doi.org/10.1128/mcb.16.5.2453
https://doi.org/10.1128/mcb.16.5.2453