Ligand binding study of human PEBP1/RKIP: interaction with nucleotides and Raf-1 peptides evidenced by NMR and mass spectrometry.

Autor: Laurette Tavel, Lucie Jaquillard, Andreas I Karsisiotis, Fabienne Saab, Laurence Jouvensal, Alain Brans, Agnès F Delmas, Françoise Schoentgen, Martine Cadene, Christian Damblon

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e36187 (2012)

BACKGROUND: Human Phosphatidylethanolamine binding protein 1 (hPEBP1) also known as Raf kinase inhibitory protein (RKIP), affects various cellular processes, and is implicated in metastasis formation and Alzheimer's disease. Human PEBP1 has also been

Externí odkaz: https://doaj.org/article/48076b07aa4c407b935f34f87599848e

Improved Accuracy of Low Affinity Protein–Ligand Equilibrium Dissociation Constants Directly Determined by Electrospray Ionization Mass Spectrometry

Autor: Fabienne Saab, Martine Cadene, Lucie Jaquillard, Françoise Schoentgen

Publikováno v: Journal of The American Society for Mass Spectrometry
Journal of The American Society for Mass Spectrometry, 2012, 23 (5), pp.908-22. ⟨10.1007/s13361-011-0305-7⟩
Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2012, 23 (5), pp.908-22. ⟨10.1007/s13361-011-0305-7⟩

International audience; There is continued interest in the determination by ESI-MS of equilibrium dissociation constants (K(D)) that accurately reflect the affinity of a protein-ligand complex in solution. Issues in the measurement of K(D) are compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb926ce8547f084a2601d109b7192913
https://doi.org/10.1007/s13361-011-0305-7

Peptides corresponding to the N- and C-terminal parts of PEBP are well-structured in solution: new insights into their possible interaction with partners in vivo

Autor: H. Labbé, Françoise Vovelle, Denise Sy, G Coadou, Françoise Schoentgen, Béatrice Vallée

Publikováno v: The Journal of Peptide Research. 61:47-57

Recently, it has been shown that mammalian PEBPs are implicated in several signalling pathways controlling the cellular cycle. In particular, during brain development, the N-terminal part of mammalian PEBP is specifically cleaved and the resulting 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba8e24f1b0e34a931e8ea53b0a0426ac
https://doi.org/10.1034/j.1399-3011.2003.21039.x

Crystal structures of YBHB and YBCL from Escherichia coli , two bacterial homologues to a Raf kinase inhibitor protein 1 1Edited by R. Huber

Autor: Nicole Bureaud, Hélène Bénédetti, Charles Zelwer, Karine Pereira de Jésus, Françoise Schoentgen, Laurence Serre

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2001, 310 (3), pp.617-634. ⟨10.1006/jmbi.2001.4784⟩

International audience; In rat and human cells, RKIP (previously known as PEBP) was characterized as an inhibitor of the MEK phosphorylation by Raf-1. In Escherichia coli, the genes ybhb and ybcl possibly encode two RKIP homologues while in the genom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab04570e674b4231c3b8e4d9ec39875
https://doi.org/10.1006/jmbi.2001.4784

Stability and physicochemical properties of the bovine brain phosphatidylethanolamine-binding protein

Autor: Françoise Schoentgen, Nicole Bureaud, Caroline Teyssier, Régine Maget-Dana, Béatrice Vallée, Jean Ramstein

Publikováno v: European Journal of Biochemistry
European Journal of Biochemistry, Wiley, 1999, 266 (1), pp.40-52

International audience; The equilibrium behaviour of the bovine phosphatidylethanolamine-binding protein (PEBP) has been studied under various conditions of pH, temperature and urea concentration. Far-UV and near-UV CD, fluorescence and Fourier trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5630fb2f5d2da6be917df73ef57e6e1a
https://doi.org/10.1046/j.1432-1327.1999.00812.x