Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Françoise S Howe"'
Autor:
Thomas Brown, Françoise S Howe, Struan C Murray, Meredith Wouters, Philipp Lorenz, Emily Seward, Scott Rata, Andrew Angel, Jane Mellor
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 2, Pp 1-21 (2018)
Abstract Antisense transcription is widespread in genomes. Despite large differences in gene size and architecture, we find that yeast and human genes share a unique, antisense transcription‐associated chromatin signature. We asked whether this sig
Externí odkaz:
https://doaj.org/article/c408574a75694f5da6f293c21d61ecc0
Autor:
Françoise S Howe, Andrew Russell, Anna R Lamstaes, Afaf El-Sagheer, Anitha Nair, Tom Brown, Jane Mellor
Publikováno v:
eLife, Vol 6 (2017)
CRISPRi, an adapted CRISPR-Cas9 system, is proposed to act as a strand-specific roadblock to repress transcription in eukaryotic cells using guide RNAs (sgRNAs) to target catalytically inactive Cas9 (dCas9) and offers an alternative to genetic interv
Externí odkaz:
https://doaj.org/article/ed121737be8b4012bce760dad1ea298a
Autor:
Tania Nguyen, Harry Fischl, Françoise S Howe, Ronja Woloszczuk, Ana Serra Barros, Zhenyu Xu, David Brown, Struan C Murray, Simon Haenni, James M Halstead, Leigh O'Connor, Gergana Shipkovenska, Lars M Steinmetz, Jane Mellor
Publikováno v:
eLife, Vol 3 (2014)
In yeast, many tandemly arranged genes show peak expression in different phases of the metabolic cycle (YMC) or in different carbon sources, indicative of regulation by a bi-modal switch, but it is not clear how these switches are controlled. Using n
Externí odkaz:
https://doaj.org/article/1151cac568dd4b539a08f1efd0b168f8
Autor:
Françoise S. Howe, Jane Mellor
Publikováno v:
Microbial Cell, Vol 1, Iss 11, Pp 390-392 (2014)
Acetylation of lysine residues has several characterised functions in chromatin. These include neutralization of the lysine’s positive charge to directly influence histone tail-DNA/internucleosomal interactions or indirect effects via bromodomain-c
Externí odkaz:
https://doaj.org/article/b90bec68d4714d0589068c076d6c29b2
Autor:
Xin Lu, Françoise S. Howe
Publikováno v:
The FEBS journalSelected publications and related interview. 287(24)
Xin Lu is Professor of Cancer Biology at the University of Oxford, UK, and Director of the Oxford Branch of the Ludwig Institute for Cancer Research, Co-director of the Cancer Research UK Oxford Centre, NIHR Oxford Biomedical Research Centre Multi-Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd205f17942c6d05e890de4a4a80e6b
https://pubmed.ncbi.nlm.nih.gov/33197146
https://pubmed.ncbi.nlm.nih.gov/33197146
Autor:
Andrew Angel, Rayappu, Tom Brown, M Wouters, Françoise S. Howe, Struan C. Murray, Khushaim W, Jane Mellor, Lorenz P, Harry Fischl, Xi S
H3K4me3 is a near-universal histone modification found predominantly at the 5’ region of genes, with a well-documented association with gene activity. H3K4me3 has been ascribed roles as both an instructor of gene expression and also a downstream co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51055c7dafd102a85ad7a4d1f0172970
https://doi.org/10.1101/709014
https://doi.org/10.1101/709014
Publikováno v:
Trends in Genetics. 32:57-71
Eukaryotic genomes are pervasively transcribed but until recently this noncoding transcription was considered to be simply noise. Noncoding transcription units overlap with genes and genes overlap other genes, meaning genomes are extensively interlea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930499967762b0f313fe6cbfe3e4c36a
https://doi.org/10.1016/j.tig.2015.10.006
https://doi.org/10.1016/j.tig.2015.10.006
Autor:
Simon Haenni, Françoise S. Howe, Jane Mellor, Karolina Chocian, Struan C. Murray, Anitha Nair, Harry Fischl
Publikováno v:
Nucleic Acids Research
Genes from yeast to mammals are frequently subject to non-coding transcription of their antisense strand; however the genome-wide role for antisense transcription remains elusive. As transcription influences chromatin structure, we took a genome-wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b2ca95ecab93a679dc3252678ddcde
https://doi.org/10.1093/nar/gkv666
https://doi.org/10.1093/nar/gkv666
Autor:
Françoise S, Howe, Jane, Mellor
Publikováno v:
Molecular Cell
Summary Gene transcription responds to stress and metabolic signals to optimize growth and survival. Histone H3 (H3) lysine 4 trimethylation (K4me3) facilitates state changes, but how levels are coordinated with the environment is unclear. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dab8d4a93d2717ad4aacf778afe32695
https://pubmed.ncbi.nlm.nih.gov/25127513
https://pubmed.ncbi.nlm.nih.gov/25127513