Cross-sectional reassessment after 4 years of clinical routine use of AQUIOS CL for absolute T cell quantitation in a university hospital

Autor: Léa Lemoine, Christophe Malcus, Françoise Poitevin‐Later, Fabienne Venet, Guillaume Monneret, Morgane Gossez

Publikováno v: Cytometry. Part B, Clinical cytometryREFERENCES. 102(5)

We had previously reported appropriate performances of automated AQUIOS CL cytometer (Beckman Coulter) for regulatory approval of absolute T cell enumeration. However, after 4 years of routine use, we still observed recurrent histogram anomalies that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1662282e31840e277f03f21d45772a2
https://pubmed.ncbi.nlm.nih.gov/35437910

Proof of concept study of mass cytometry in septic shock patients reveals novel immune alterations

Autor: Sophie Debord, Thibault Andrieu, Christophe Malcus, Fabienne Venet, Guillaume Monneret, Françoise Poitevin-Later, Frédérique Bayle, Morgane Gossez, Thomas Rimmelé

Publikováno v: Scientific Reports
Scientific Reports, 2018, 8 (1), pp.17296. ⟨10.1038/s41598-018-35932-0⟩
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Innovative single cell technologies such as mass cytometry (CyTOF) widen possibilities to deeply improve characterisation of immune alterations mechanisms in human diseases. So far, CyTOF has not been used in sepsis – a condition characterized by c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb8c39cdccccb97c1f98eda51c37194
https://univ-lyon1.hal.science/hal-04050688/file/s41598-018-35932-0.pdf

Marked alterations of neutrophil functions during sepsis-induced immunosuppression

Autor: Françoise Poitevin-Later, Christophe Malcus, Marie-Angélique Cazalis, Alain Lepape, Fabienne Venet, Julie Demaret, Julien Textoris, Arnaud Friggeri, Guillaume Monneret, Jonathan Plassais, Laurent Jallades

Publikováno v: Journal of Leukocyte Biology. 98:1081-1090

Severe septic syndromes deeply impair innate and adaptive immunity and are responsible for sepsis-induced immunosuppression. Although neutrophils represent the first line of defense against infection, little is known about their phenotype and functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b9b76d9b290fbd755acf858a2a64e5
https://doi.org/10.1189/jlb.4a0415-168rr

Septic Shock Shapes B Cell Response toward an Exhausted-like/Immunoregulatory Profile in Patients

Autor: Fabienne Venet, Alain Lepape, Thomas Rimmelé, Morgane Gossez, Laurent Jallades, Claude-Alexandre Gustave, Julien Textoris, Julie Demaret, Françoise Poitevin-Later, Guillaume Monneret, Christophe Malcus

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 200(7)

Septic shock is accompanied by the development of immune dysfunctions whose intensity and duration are associated with increased risk of secondary infections and mortality. Although B lymphocytes play a pivotal role in the immune response to infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eacaff44feffe7c593fed679dc4383b
https://pubmed.ncbi.nlm.nih.gov/29459404

Decreased T-Cell Repertoire Diversity in Sepsis

Autor: Nadia Plantier, Nicolas Pasqual, Orchidée Filipe-Santos, Christophe Malcus, Françoise Poitevin-Later, Alain Lepape, Guillaume Monneret, Audrey Grives, Fabienne Venet

Publikováno v: Critical Care Medicine
Critical Care Medicine, 2013, 41 (1), pp.111-119. ⟨10.1097/CCM.0b013e3182657948⟩

International audience; Objective: Septic syndromes are the leading causes of mortality in intensive care units. In patients, the occurrence of sepsis-induced immune suppression is associated with delayed mortality, although the exact role of lymphoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48e7f64de563e3c5312b5781b638b4d
https://doi.org/10.1097/ccm.0b013e3182657948