Výsledky vyhledávání - "Françoise Picard"

Activation of PAK1/2 during the shedding of platelet microvesicles

Autor: Catherine Vidal, Françoise Picard, Michaela Fontenay, Catherine Lacombe, Malvina Crespin

Publikováno v: Blood Coagulation & Fibrinolysis. 20:63-70

Simultaneously to phospholipid flip-flop that supports the procoagulant activity of activated platelets, blebs, supported by actin reorganization, are formed at the plasma membrane and generate microvesicles. The molecular mechanism of microvesicle s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43ac6e36a45850927de1a6038598ec3
https://doi.org/10.1097/mbc.0b013e32831bc310

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Deciphering leukemic B-cell chronic lymphoproliferative disorders

Autor: Isabelle Radford-Weiss, Chantal Brouzes, Rémi Letestu, M. Guesnu, Florence Ajchenbaum-Cymbalista, Vincent Levy, Valérie Ugo, Françoise Valensi, Nathalie Leporrier, Sylvie Ramond, Jean-Yves Perrot, Joelle Nataf, Françoise Picard, Véronique Salaun, Xavier Troussard

Publikováno v: Leukemia & Lymphoma. 47:2088-2095

Diagnosis of leukemic B-cell chronic lymphoproliferative disorders (B-CLPD) is a frequent challenge in hematology. In this multicentric study, we prospectively studied 165 new consecutive leukemic patients with B-CLPD selected on the basis of Royal M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab69b6a5b52c1fe45fd12f8e497d9d2
https://doi.org/10.1080/10428190600727939

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Immunophenotypic clustering of myelodysplastic syndromes

Autor: Bernard Husson, Geneviève Le Roux, Michelle Rosenwadj, Martine Raphael, Veronique Vergé, Marie C. Béné, Jean Feuillard, Françoise Picard, Philippe Bissières, Marc Maynadié, A. Dromelet, Lydia Campos, Pascalle Lepelley, Michèle Imbert, Groupe d'Etude Immunologique des Leucémies, Yvan Cornet, Bernard Chatelain, Hélène Jouault

Publikováno v: Blood. 100:2349-2356

Myelodysplastic syndromes (MDSs) are heterogeneous diseases of bone marrow (BM) cell precursors for which immunophenotypic characterization is still considered irrelevant despite the accuracy and sensitivity of flow cytometry techniques. The aim of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f5b9d22a8b8d6e0da41f0ca14cc7d8
https://doi.org/10.1182/blood-2002-01-0230

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In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: evidence for Fas-dependent apoptosis

Autor: Sylvie Gisselbrecht, Françoise Picard, Catherine Lacombe, Didier Bouscary, Patrick Mayeux, Michaëla Fontenay-Roupie, Yann-Erick Claessens, François Dreyfus, J. Melle, Jean-Michel Dupont

Publikováno v: Blood. 99:1594-1601

Erythropoiesis results from the proliferation and differentiation of pluripotent stem cells into immature erythroid progenitors (ie, erythroid burst-forming units (BFU-Es), whose growth, survival, and terminal differentiation depends on erythropoieti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1d0330f922d319ee136af82b8224bc
https://doi.org/10.1182/blood.v99.5.1594

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Flow Cytometry Detection of Platelet Procoagulant Activity and Microparticles in Patients with Unstable Angina Treated by Percutaneous Coronary Angioplasty and Stent Implantation

Autor: Françoise Picard, J. Melle, Catherine Vidal, Christian Spaulding, Frédéric Schaison, Michaëla Fontenay-Roupie, Simon Weber

Publikováno v: Thrombosis and Haemostasis. 86:784-790

SummaryPlatelet activation is known to participate to the pathogenesis of acute coronary syndromes. Aminophospholipid exposure and micro-particles shedding are hallmarks of full platelet activation and may account for the dissemination of prothrombot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b6eef8a3efea0d4346c9b18e2148a14
https://doi.org/10.1055/s-0037-1616132

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Autor: Franck Viguié, Nicole Casadevall, Francois Dreyfus, Jean-Pierre Marie, Ollivier Legrand, Simona Zompi, Claude Blanc, Didier Bouscary, Françoise Picard

Publikováno v: British Journal of Haematology. 110:610-613

We describe two patients with positive t(15;17) acute promyelocytic leukaemia (APL) that developed into a therapy-related myelodysplasia 2-2.5 years after complete remission (CR) and then evolved into therapy-related acute myeloid leukaemia (t-AML).

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https://doi.org/10.1046/j.1365-2141.2000.02240.x

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Megakaryocyte Growth and Development Factor-Induced Proliferation and Differentiation Are Regulated by the Mitogen-Activated Protein Kinase Pathway in Primitive Cord Blood Hematopoietic Progenitors

Autor: Françoise Porteu, Mustapha Cherai, Serge Fichelson, Sylvie Gisselbrecht, Françoise Picard, Michaëla Fontenay-Roupie, Jean-Marc Freyssinier, Martine Guesnu

Publikováno v: Blood. 94:1601-1613

In several erythroleukemia cell lines, activation of mitogen-activated protein kinases (MAPK) by phorbol esters or megakaryocyte growth and development factor (MGDF) is required for induction of megakaryocytic phenotype and growth arrest. To support

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cdb13d7df36b54fef85345b14edc99
https://doi.org/10.1182/blood.v94.5.1601

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Ineffective erythropoiesis in myelodysplastic syndromes: correlation with Fas expression but not with lack of erythropoietin receptor signal transduction

Autor: Martine Guesnu, François Dreyfus, Sylvie Gisselbrecht, J. Melle, Didier Bouscary, Patrick Mayeux, Françoise Picard, Catherine Lacombe, Michaëla Fontenay-Roupie

Publikováno v: British Journal of Haematology. 106:464-473

Ineffective erythropoiesis in myelodysplasia is characterized by a defect in erythroid progenitor growth and by abnormal erythroid differentiation. Increased apoptosis of erythroid, granulocytic and megakaryocytic lineages is thought to account for c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f18bf448af560919b86c43c4db1b211
https://doi.org/10.1046/j.1365-2141.1999.01539.x

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Analysis of megakaryocyte growth and development factor (thrombopoietin) effects on blast cell and megakaryocyte growth in myelodysplasia

Autor: M. Fontenay-Roupie, Françoise Picard, Nicole Casadevall, Josiane Melle, François Dreyfus, Didier Bouscary, Serge Fichelson, Martine Guesnu, Anne Botella, Jean-Michel Dupont

Publikováno v: Leukemia Research. 22:527-535

Thrombocytopenia is a frequent feature of myelodysplastic syndromes (MDS) that could be improved by the use of recombinant human megakaryocyte growth and development factor (rHuMGDF). Using short-term liquid cultures and progenitor assays, we have fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d4ea385d7156c6d21cf50e521a43af
https://doi.org/10.1016/s0145-2126(98)00028-9

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