The Leech Nervous System: A Valuable Model to Study the Microglia Involvement in Regenerative Processes

Autor: Françoise Le Marrec-Croq, Francesco Drago, Jacopo Vizioli, Pierre-Eric Sautière, Christophe Lefebvre

Publikováno v: Clinical and Developmental Immunology, Vol 2013 (2013)

Microglia are intrinsic components of the central nervous system (CNS). During pathologies in mammals, inflammatory processes implicate the resident microglia and the infiltration of blood cells including macrophages. Functions of microglia appear to

Externí odkaz: https://doaj.org/article/3ed30944f1194891bb5ecb8e556fb32f

Medicinal Leech CNS as a Model for Exosome Studies in the Crosstalk between Microglia and Neurons

Autor: Michel Salzet, Issa Al-Amri, Quentin Lemaire, Pierre-Eric Sautière, Tanina Arab, Françoise Le Marrec-Croq, Antonella Raffo-Romero, Jacopo Vizioli, Christelle Van Camp, Christophe Lefebvre

Publikováno v: International Journal of Molecular Sciences
Volume 19
Issue 12
International Journal of Molecular Sciences, Vol 19, Iss 12, p 4124 (2018)
International Journal of Molecular Sciences, MDPI, 2018, 19 (12), pp.4124. ⟨10.3390/ijms19124124⟩
International Journal of Molecular Sciences, 2018, 19 (12), pp.4124. ⟨10.3390/ijms19124124⟩

In healthy or pathological brains, the neuroinflammatory state is supported by a strong communication involving microglia and neurons. Recent studies indicate that extracellular vesicles (EVs), including exosomes and microvesicles, play a key role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475637c92c8a9d0cf01bbb403b37c3a8
http://europepmc.org/articles/PMC6321190

Calreticulin contributes to C1q-dependent recruitment of microglia in the leech Hirudo medicinalis following a CNS injury

Autor: Julien Franck, Michel Salzet, Pierre-Eric Sautière, Francesco Drago, Françoise Le Marrec-Croq, Annelise Bocquet-Garcon, Christophe Lefebvre, Maxence Wisztorski, Christelle Vancamp, Jacopo Vizioli

Publikováno v: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

BACKGROUND The medicinal leech is considered as a complementary and appropriate model to study immune functions in the central nervous system (CNS). In a context in which an injured leech's CNS can naturally restore normal synaptic connections, the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8565ed33e785874eeb1d59b27e761365
https://doi.org/10.12659/msm.890091

Microglia of medicinal leech (Hirudo medicinalis) express a specific activation marker homologous to vertebrate ionized calcium-binding adapter molecule 1 (Iba1/alias aif-1)

Autor: Francesco, Drago, Pierre-Eric, Sautière, Françoise, Le Marrec-Croq, Alice, Accorsi, Christelle, Van Camp, Michel, Salzet, Christophe, Lefebvre, Jacopo, Vizioli

Publikováno v: Developmental neurobiology. 74(10)

The Ionized calcium-Binding Adapter molecule 1 (Iba1), also known as Allograft Inflammatory Factor 1 (AIF-1), is a 17 kDa cytokine-inducible protein, produced by activated macrophages during chronic transplant rejection and inflammatory reactions in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31026b12146c239dfd73b910de845161
https://pubmed.ncbi.nlm.nih.gov/24723370

Hedistin: A novel antimicrobial peptide containing bromotryptophan constitutively expressed in the NK cells-like of the marine annelid, Nereis diversicolor

Autor: Christelle Pontoire-Van Camp, Pierre-Eric Sautière, Aurélie Tasiemski, David Schikorski, Céline Boidin-Wichlacz, Françoise Le Marrec-Croq

Publikováno v: Developmental and comparative immunology. 31(8)

A novel antimicrobial peptide, named hedistin was identified from the coelomocytes of Nereis diversicolor. Hedistin shows no obvious similarities with other known peptides and constitutes the first antimicrobial peptide containing bromotryptophans de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535cd8137e322c8c8196ebcf4d377562
https://pubmed.ncbi.nlm.nih.gov/17210178