Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Françoise Kühne"'
Autor:
Yasmine Neirijnck, Pauline Sararols, Françoise Kühne, Chloé Mayère, Lahiru Chamara Weerasinghe Arachchige, Violaine Regard, Serge Nef, Andreas Schedl
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112191- (2023)
Summary: Adrenal cortex and gonads represent the two major steroidogenic organs in mammals. Both tissues are considered to share a common developmental origin characterized by the expression of Nr5a1/Sf1. The precise origin of adrenogonadal progenito
Externí odkaz:
https://doaj.org/article/a149403cc94642d78646525003993975
Autor:
Pauline Sararols, Isabelle Stévant, Yasmine Neirijnck, Diane Rebourcet, Annalucia Darbey, Michael K. Curley, Françoise Kühne, Emmanouil Dermitzakis, Lee B. Smith, Serge Nef
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Leydig cells (LC) are the main testicular androgen-producing cells. In eutherian mammals, two types of LCs emerge successively during testicular development, fetal Leydig cells (FLCs) and adult Leydig cells (ALCs). Both display significant difference
Externí odkaz:
https://doaj.org/article/85ebc7785bcf4017aef56eb2a96b18d9
Autor:
Caroline Cazin, Yasmine Neirijnck, Corinne Loeuillet, Lydia Wehrli, Françoise Kühne, Isabelle Lordey, Selima Fourati Ben Mustapha, Amin Bouker, Raoudha Zouari, Nicolas Thierry-Mieg, Serge Nef, Christophe Arnoult, Pierre F. Ray, Zine-Eddine Kherraf
Publikováno v:
Cells, Vol 11, Iss 1, p 118 (2021)
The genetic landscape of male infertility is highly complex. It is estimated that at least 4000 genes are involved in human spermatogenesis, but only few have so far been extensively studied. In this study, we investigated by whole exome sequencing t
Externí odkaz:
https://doaj.org/article/cefaab1e590541ddbadfb7cc15ec9d6a
Autor:
Isabelle Stévant, Françoise Kühne, Andy Greenfield, Marie-Christine Chaboissier, Emmanouil T. Dermitzakis, Serge Nef
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3272-3283.e3 (2019)
Summary: Sex determination is a unique process that allows the study of multipotent progenitors and their acquisition of sex-specific fates during differentiation of the gonad into a testis or an ovary. Using time series single-cell RNA sequencing (s
Externí odkaz:
https://doaj.org/article/cce02257bf094e28a23769e1b91fdbb5
Autor:
Caroline Cazin, Yasmine Neirijnck, Corinne Loeuillet, Lydia Wehrli, Françoise Kühne, Isabelle Lordey, Selima Fourati Ben Mustapha, Amin Bouker, Raoudha Zouari, Nicolas Thierry-Mieg, Serge Nef, Christophe Arnoult, Pierre F. Ray, Zine-Eddine Kherraf
Publikováno v:
Cells, Vol 11, Iss 118, p 118 (2022)
Cells
Cells, 2022, 11 (1), pp.118. ⟨10.3390/cells11010118⟩
Cells; Volume 11; Issue 1; Pages: 118
Cells
Cells, 2022, 11 (1), pp.118. ⟨10.3390/cells11010118⟩
Cells; Volume 11; Issue 1; Pages: 118
The genetic landscape of male infertility is highly complex. It is estimated that at least 4000 genes are involved in human spermatogenesis, but only few have so far been extensively studied. In this study, we investigated by whole exome sequencing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37818250a8b51dfe9cce3ed28c8c7201
https://www.mdpi.com/2073-4409/11/1/118
https://www.mdpi.com/2073-4409/11/1/118
Autor:
Lee B. Smith, Diane Rebourcet, Isabelle Stévant, Emmanouil T. Dermitzakis, Annalucia Darbey, Yasmine Neirijnck, Françoise Kühne, Serge Nef, Pauline Sararols, Michael Curley
Leydig cells (LC) are the main testicular androgen-producing cells. In eutherian mammals, two types of LCs emerge successively during testicular development, fetal Leydig cells (FLCs) and adult Leydig cells (ALCs). Both display significant difference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b76d4a99254a99f315f829ae5f1ac50
https://doi.org/10.1101/2021.04.14.439819
https://doi.org/10.1101/2021.04.14.439819
Autor:
Anne-Amandine Chassot, Chloé Mayère, Isabelle Stévant, Emmanouil T. Dermitzakis, Pauline Sararols, Yasmine Neirijnck, Françoise Kühne, Chris M Rands, Marie-Christine Chaboissier, Serge Nef
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2021, 35 (4), ⟨10.1096/fj.202002420R⟩
FASEB Journal, 2021, 35 (4), ⟨10.1096/fj.202002420R⟩
FASEB Journal, Vol. 35, No 4 (2021) P. e21452
FASEB Journal, Federation of American Society of Experimental Biology, 2021, 35 (4), ⟨10.1096/fj.202002420R⟩
FASEB Journal, 2021, 35 (4), ⟨10.1096/fj.202002420R⟩
FASEB Journal, Vol. 35, No 4 (2021) P. e21452
Despite the importance of germ cell (GC) differentiation for sexual reproduction, the gene networks underlying their fate remain unclear. Here, we comprehensively characterize the gene expression dynamics during sex determination based on single-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55cc14c60b0ffe8acdb1b5cf4ab0aea
https://hal.archives-ouvertes.fr/hal-03215407
https://hal.archives-ouvertes.fr/hal-03215407
Autor:
Serge Nef, Violaine Regard, Pauline Sararols, Aitana Perea-Gomez, Andy Greenfield, Chloé Mayère, Cyril Djari, Isabelle Stévant, Dagmar Wilhelm, Diana Condrea, Michelle Simon, Richard Reeves, Corey Bunce, Françoise Kühne, Ivana Gantar, Marie-Christine Chaboissier, Laura Batti, Blanche Capel, Pam Siggers, Furong Tang, Simon Greenaway, Norbert B. Ghyselinck, Yasmine Neirijnck
Publikováno v:
Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2022, 8 (21), ⟨10.1126/sciadv.abm0972⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2022, 8 (21), ⟨10.1126/sciadv.abm0972⟩
Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. Here, we investigated the origin, specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6e15a3a3a4d77a50543cd79afaaad0
https://hal.archives-ouvertes.fr/hal-03370834/file/2021.09.15.460431v1.full.pdf
https://hal.archives-ouvertes.fr/hal-03370834/file/2021.09.15.460431v1.full.pdf
Autor:
Françoise Kühne, Yasmine Neirijnck, Pauline Sararols, Serge Nef, Michelangelo Foti, Nina Atanassova, Chloé Mayère, Ekaterina Pavlova
Publikováno v:
Endocrinology, Vol. 160, No 2 (2019) pp. 387-398
The IGFs are the major intratesticular factors regulating immature Sertoli cell proliferation and are, therefore, critical to establish the magnitude of sperm production. However, the intratesticular source of IGF production and the downstream signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181e5955ac81543eb4918680eb2addd1
https://doi.org/10.1210/en.2018-00892
https://doi.org/10.1210/en.2018-00892
Autor:
Richard J. Griffeth, Isabelle Stévant, François P. Pralong, Jean-Luc Pitetti, Françoise Kühne, Meng-Chun Hu, Silvana A. Andric, Yasmine Neirijnck, Lee B. Smith, Serge Nef, Karen R. Kilcoyne, Pierre Calvel
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2018, 32 (6), pp.3321-3335. ⟨10.1096/fj.201700769RR⟩
FASEB Journal, Vol. 32, No 6 (2018) pp. 3321-3335
FASEB Journal, Federation of American Society of Experimental Biology, 2018, 32 (6), pp.3321-3335. ⟨10.1096/fj.201700769RR⟩
FASEB Journal, Vol. 32, No 6 (2018) pp. 3321-3335
The insulin family of growth factors (insulin, IGF1, and IGF2) are critical in sex determination, adrenal differentiation, and testicular function. Notably, the IGF system has been reported to mediate the proliferation of steroidogenic cells. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f829d7e797a9797ee78be1d98552a325
https://doi.org/10.1096/fj.201700769RR
https://doi.org/10.1096/fj.201700769RR