Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Françoise Finiels"'
Autor:
Françoise Finiels, Pierre-François Pradat, Philippe Kennel, Pia Delaere, Frederic Revah, Cecile Orsini, Souad Naimi-Sadaoui, Jacques Mallet
Publikováno v:
Human Gene Therapy. 12:2237-2249
Neurotrophic factors (NFs) are promising agents for the treatment of peripheral neuropathies such as diabetic neuropathy. However, the value of treatment with recombinant NF is limited by the short half-lives of these molecules, which reduces efficie
Autor:
Philippe Kennel, Souad Naimi, Pierre-François Pradat, Frederic Revah, Jacques Mallet, Cecile Orsini, Françoise Finiels, Pia Delaere
Publikováno v:
Human Gene Therapy. 12:367-375
Cisplatin-induced sensory peripheral neuropathy is the dose-limiting factor for cisplatin chemotherapy. We describe the preventive effect of NT-3 delivery, using direct gene transfer into muscle by in vivo electroporation in a mouse model of cisplati
Autor:
Jacques Mallet, Vincent Navarro, Hélène Kiefer, Jean-Jacques Robert, Françoise Finiels, Stéphanie Millecamps, Marie-Claude Geoffroy, Martine Barkats
Publikováno v:
ResearcherID
Nature Biotechnology
Nature Biotechnology, Nature Publishing Group, 1999, 17 (9), pp.865-869. ⟨10.1038/12849⟩
Nature Biotechnology, 1999, 17 (9), pp.865-869. ⟨10.1038/12849⟩
Nature Biotechnology
Nature Biotechnology, Nature Publishing Group, 1999, 17 (9), pp.865-869. ⟨10.1038/12849⟩
Nature Biotechnology, 1999, 17 (9), pp.865-869. ⟨10.1038/12849⟩
International audience; Neuron-restrictive silencer elements (NRSEs) were used to target the gene expression of adenoviral vectors specifically to neuron cells in the central nervous system. By generating adenoviral constructs in which NRSE sequences
Autor:
Frédéric Revah, Françoise Finiels, Olga Corti, Jacques Mallet, Philippe Horellou, Martine Barkats, Alicia Bilang-Bleuel, O Sabate, Marie-Hélène Buc-Caron, M.N. Castel-Barthe
Publikováno v:
Progress in Neurobiology. 55:333-341
Adenovirus is an efficient vector for neuronal gene therapy due to its ability to infect post-mitotic cells, its high efficacy of cell transduction and its low pathogenicity. Recombinant adenoviruses encoding for therapeutical agents can be delivered
Autor:
Jacques Mallet, Frédéric Revah, Jean-Louis Dufier, Florence Ribeaudeau, Françoise Finiels, Marc Abitbol, Paul Roustan
Publikováno v:
Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie. 320:523-532
A successful surgical access to the subretinal space is critical for achieving adenovirus-mediated gene transfer to the retinal pigment epithelial (RPE) cells or photoreceptor cells. We report a novel surgical approach allowing an efficient delivery
Publikováno v:
Journal of Neurochemistry. 60:1968-1971
Recent reports suggest that NMDA receptor antagonists when administered in vivo can protect dopaminergic neurons from the toxic actions of MPP+. In the present study the possible neuroprotective effects against MPP+ toxicity of the noncompetitive NMD
Publikováno v:
Neurochemistry International. 19:93-102
The evolution of protein kinase C (PKC) is studied over the development of primary culture of neurons, performed with raphe nuclei cells of 14 days old rat embryos. The amount of PKC, expressed per mg of protein, is increased during the first week of
Failure of a protein synthesis inhibitor to modify glutamate receptor-mediated neurotoxicity in vivo
Autor:
Jacqueline N. Crawley, Françoise Finiels-Marlier, C. Leppin, Pascale Montpied, Steven M. Paul
Publikováno v:
Brain Research. 581:168-170
The delayed neuronal death (DND) resulting from brief forebrain ischemia has recently been reported to be markedly attenuated by parenteral administration of the reversible protein synthesis inhibitor, anisomycin. Previous work suggests that ischemia
Publikováno v:
Journal of Neurochemistry
Journal of Neurochemistry, Wiley, 1997, 68 (5), pp.2152-2160. ⟨10.1046/j.1471-4159.1997.68052152.x⟩
Journal of Neurochemistry, Wiley, 1997, 68 (5), pp.2152-2160. ⟨10.1046/j.1471-4159.1997.68052152.x⟩
We validated an adenoviral vector-based system as a move toward the characterization of regulatory sequences that are involved in the control of cell-type specificity and ligand regulation of neuronal gene expression in cultured neurons. We construct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d71c8c97ccc7aa5fc8f24ddbc609ac
https://hal-cnrs.archives-ouvertes.fr/hal-03083411
https://hal-cnrs.archives-ouvertes.fr/hal-03083411
Publikováno v:
Neuroreport. 7(8)
Dominant mutations of human Cu/Zn superoxide dismutase (SOD1) are found in about 20% of patients with familial amyotrophic lateral sclerosis (FALS). A transgenic mouse model of FALS (FALSG93A mice) has been generated by overexpression of a mutated fo