Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities

Autor: Sophie Cardin, Mélanie Bilodeau, Mathieu Roussy, Léo Aubert, Thomas Milan, Loubna Jouan, Alexandre Rouette, Louise Laramée, Patrick Gendron, Jean Duchaine, Hélène Decaluwe, Jean-François Spinella, Stéphanie Mourad, Françoise Couture, Daniel Sinnett, Élie Haddad, Josette-Renée Landry, Jing Ma, R. Keith Humphries, Philippe P. Roux, Josée Hébert, Tanja A. Gruber, Brian T. Wilhelm, Sonia Cellot

Publikováno v: Blood Advances, Vol 3, Iss 21, Pp 3307-3321 (2019)

Abstract: Acute megakaryoblastic leukemia (AMKL) represents ∼10% of pediatric acute myeloid leukemia cases and typically affects young children (

Externí odkaz: https://doaj.org/article/a470cd10a4664d67873fc05b7a49373e

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities

Autor: Josette-Renée Landry, Patrick Gendron, Stéphanie Mourad, Philippe P. Roux, Brian T. Wilhelm, Hélène Decaluwe, Thomas Milan, Louise Laramée, Loubna Jouan, Daniel Sinnett, R. Keith Humphries, Sonia Cellot, Françoise Couture, Jean-François Spinella, Mathieu Roussy, Josée Hébert, Jing Ma, Sophie Cardin, Alexandre Rouette, Tanja A. Gruber, Jean Duchaine, Léo Aubert, Elie Haddad, Mélanie Bilodeau

Publikováno v: Blood Advances. 3:3307-3321

Acute megakaryoblastic leukemia (AMKL) represents ∼10% of pediatric acute myeloid leukemia cases and typically affects young children (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e13efc599c62db5cdc3edcd6ed01d90
https://doi.org/10.1182/bloodadvances.2019030981

NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy

Autor: Mathieu Roussy, Mélanie Bilodeau, Loubna Jouan, Pauline Tibout, Louise Laramée, Emmanuelle Lemyre, France Léveillé, Frédérique Tihy, Sophie Cardin, Camille Sauvageau, Françoise Couture, Isabelle Louis, Aurélien Choblet, Natalie Patey, Patrick Gendron, Michel Duval, Pierre Teira, Josée Hébert, Brian T. Wilhelm, John K. Choi, Tanja A. Gruber, Henrique Bittencourt, Sonia Cellot

Publikováno v: Genes, Chromosomes and Cancer. 57:311-319

The advent of large scale genomic sequencing technologies significantly improved the molecular classification of acute megakaryoblastic leukaemia (AMKL). AMKL represents a subset (∼10%) of high fatality pediatric acute myeloid leukemia (AML). Recur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c361bd22e7282fb8dc156289bb76023
https://doi.org/10.1002/gcc.22532

Novel PDE10A-BRAF Fusion With Concomitant NF1 Mutation Identified in an Undifferentiated Sarcoma of Infancy With Sustained Response to Trametinib.

Autor: Vairy S; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Jouan L; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Bilodeau M; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Dormoy-Raclet V; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Gendron P; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Couture F; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Léveillé F; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Tihy F; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Lemyre E; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Bouron-Dal Soglio D; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Jabado N; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Kleinman CL; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Marzouki M; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France., Cellot S; Stéphanie Vairy, Mélanie Bilodeau, Monia Marzouki, and Sonia Cellot, Charles-Bruneau Cancer Center; Stéphanie Vairy, Loubna Jouan, Mélanie Bilodeau, Françoise Couture, France Léveillé, Frédérique Tihy, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Centre Hospitalier Universitaire Sainte-Justine; Patrick Gendron, Emmanuelle Lemyre, Dorothée Bouron-Dal Soglio, Monia Marzouki, and Sonia Cellot, Université de Montréal; Nada Jabado and Claudia L. Kleinman, McGill University; Claudia L. Kleinman, Jewish General Hospital, Montreal, Quebec, Canada; and Virginie Dormoy-Raclet, Hôpital Pellegrin, Bordeaux, France.

Publikováno v: JCO precision oncology [JCO Precis Oncol] 2018 Nov; Vol. 2, pp. 1-13.