In Vivo Evaluation of Innovative Gadolinium-Based Contrast Agents Designed for Bioimaging Applications

Autor: Sorina Nicoleta Voicu, Cecilia Virginia Gheran, Cornel Balta, Anca Hermenean, Maité Callewaert, Françoise Chuburu, Anca Dinischiotu

Publikováno v: Polymers, Vol 16, Iss 8, p 1064 (2024)

The aim of this study was the investigation of biochemical and histological changes induced in different tissues, as a result of the subcutaneous administration of Gd nanohydrogels (GdDOTA⸦CS-TPP/HA) in a CD-1 mouse strain. The nanohydrogels were o

Externí odkaz: https://doaj.org/article/4e77e1e2954f486592f9fe1f81eddc60

Synthesis and Characterization of Conjugated Hyaluronic Acids. Application to Stability Studies of Chitosan-Hyaluronic Acid Nanogels Based on Fluorescence Resonance Energy Transfer

Autor: Volodymyr Malytskyi, Juliette Moreau, Maité Callewaert, Céline Henoumont, Cyril Cadiou, Cécile Feuillie, Sophie Laurent, Michael Molinari, Françoise Chuburu

Publikováno v: Gels, Vol 8, Iss 3, p 182 (2022)

Hyaluronic acid (HA) was functionalized with a series of amino synthons (octylamine, polyethylene glycol amine, trifluoropropyl amine, rhodamine). Sodium hyaluronate (HAs) was first converted into its protonated form (HAp) and the reaction was conduc

Externí odkaz: https://doaj.org/article/22fa250717c344f7aa17d15d03ba167c

Biocompatibility of Gd-Loaded Chitosan-Hyaluronic Acid Nanogels as Contrast Agents for Magnetic Resonance Cancer Imaging

Autor: Cecilia Virginia Gheran, Guillaume Rigaux, Maité Callewaert, Alexandre Berquand, Michael Molinari, Françoise Chuburu, Sorina Nicoleta Voicu, Anca Dinischiotu

Publikováno v: Nanomaterials, Vol 8, Iss 4, p 201 (2018)

Although the research on nanogels incorporating Gd chelates for theranostic applications has grown exponentially in recent years, knowledge about their biocompatibility is limited. We compared the biocompatibility of Gd-loaded hyaluronic acid-chitosa

Externí odkaz: https://doaj.org/article/74985fc79c614f149035fde50e760e4b

Encapsulation of Paramagnetic Chelates in Perfluorocarbon-loaded Fractal Nanoparticles Enables Modulation of Fluorine-19 and Proton Magnetic Resonance Imaging Signal

Autor: Margot Verbeelen, Paul White, Alexander H.J. Staal, Edyta Swider-Cios, Kimberly R.G. Cortenbach, N. Koen van Riessen, Cyril Cadiou, Françoise Chuburu, Mangala Srinivas, Olga Koshkina

19F magnetic resonance imaging (19F MRI) is an emerging technique for quantitative imaging of novel therapies, such as cellular therapies and theranostic nanoparticles. A modification of perfluorocarbon (PFC)-loaded, nanocarrier-based 19F MRI probes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc4e3f201a3c4e299753c568769b4c6
https://doi.org/10.26434/chemrxiv-2021-wr46c-v2

Pyclen-based Gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive MRI nanoprobes: Synthesis and relaxation studies

Autor: Françoise Chuburu, Sophie Laurent, Maité Callewaert, Céline Henoumont, Cyril Cadiou, Michael Molinari, Fabienne Dioury, Marc Port, Christophe Portefaix

Publikováno v: Results in Chemistry
Results in Chemistry, Elsevier, 2021, 3, pp.100237. ⟨10.1016/j.rechem.2021.100237⟩
Results in Chemistry, Vol 3, Iss, Pp 100237-(2021)

A straightforward method for synthesizing at the multigram scale a low molecular weight PCTA-based gadolinium complex bearing an ionizable oxyacetic chain on the pyridine unit was described, together with its encapsulation within a nanohydrogel matri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd6c033096832e11a1a034af851b6d0
https://hal.archives-ouvertes.fr/hal-03435946/document