Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Françoise Bressolle"'
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract The objective of this study was to evaluate the performances of the propensity score weighted (PSW) methodology in a post-hoc re-analysis of a failed and a negative RCTs in depressive disorders. The conventional study designs, randomizations
Externí odkaz:
https://doaj.org/article/da1311d491104940bcf1bb42f6bab8db
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Treatment effect in clinical trials for major depressive disorders (RCT) can be viewed as the resultant of treatment specific and non-specific effects. Baseline individual propensity to respond non-specifically to any treatment or interventi
Externí odkaz:
https://doaj.org/article/6be6041213504b87a7804d3550858cc2
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics.
The aim of this paper was to develop a new modeling approach for describing the paliperidone PK resulting from the administration of extended-release once-a-day oral dose, and once- and three monthly long-acting injectable products and to compare the
Publikováno v:
Clinical Pharmacology & Therapeutics. 106:1253-1260
One of the most important reasons for failure of placebo-controlled randomized controlled clinical trials (RCTs) is the lack of appropriate methodologies for detecting treatment effect (TE; difference between placebo and active treatment response) in
Autor:
Thomas J. Spencer, Stephen V. Faraone, Roberto Gomeni, Françoise Bressolle-Gomeni, Lanyan Lucy Fang, Andrew Babiskin
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
The net benefit of a treatment can be defined by the relationship between clinical improvement and risk of adverse events: the benefit-risk ratio. The optimization of the benefit-risk ratio can be achieved by identifying the most adequate dose (and/o
Publikováno v:
Journal of Clinical Pharmacology
The interest in the development and the therapeutic use of long‐acting injectable (LAI) products for chronic or long‐term treatments has grown exponentially. The complexity and the multiphase drug release process represent serious issues for an e
Publikováno v:
The AAPS Journal. 22
Different approaches based on deconvolution and convolution analyses have been proposed to establish IVIVC. A new implementation of the convolution-based model was used to evaluate the time-scaled IVIVC using the convolution (method 1) and the deconv
Publikováno v:
The AAPS Journal. 22
The convolution-based modeling approach has been shown to be flexible and easy to implement for performing a deconvolution analysis and for assessing in vitro/in vivo correlation using non-linear regression and a pre-specified model describing the in
Publikováno v:
The Journal of Clinical Pharmacology. 58:740-749
The conventional statistical methodologies for evaluating treatment effect are based on hypothesis testing (P-value). Alternative measurements of treatment effect have been proposed for anti-infective treatments using the probability of target attain
Autor:
Sharon Wein, Thierry Durand, Françoise Bressolle, Séverine Denoyelle, Olivier Berger, Stéphanie Ortial, Henri Vial, Roger Escale, Yen Vo-Hoang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2019, 29, pp.2203-2207. ⟨10.1016/j.bmcl.2019.06.045⟩
Bioorganic & Medicinal Chemistry Letters, 2019, 29, pp.2203-2207. ⟨10.1016/j.bmcl.2019.06.045⟩
Plasmodium falciparum is responsible for most of the cases of malaria and its resistance to established antimalarial drugs is a major issue. Thus, new chemotherapies are needed to fight the emerging multi-drug resistance of P. falciparum malaria, lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a801545a0604ede7f74093c0524614a
https://hal.archives-ouvertes.fr/hal-03488325
https://hal.archives-ouvertes.fr/hal-03488325