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Autor:
Jacqueline Duffour, Patrick Chalbos, Françoise Desseigne, Frédéric Pinguet, Charles Debrigode, Sylvain Poujol, Sophie Gourgou, Laurent Mineur, Marc Ychou, Françoise Bressole
Publikováno v:
Cancer Chemotherapy and Pharmacology. 60:383-389
Irinotecan at 180 mg/m² combined with an infusional 5-fluorouracil/leucovorin (5-FU/LV) regimen (FOLFIRI) is a standard first line therapy for metastatic colorectal cancer (mCRC). This phase II study aimed to assess whether increasing the irinotecan