Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Françoise Beslot"'
Autor:
Françoise Beslot, Marie-Emmanuelle Million, Bruno Bellier, Dominique Crété, André Bado, Christiane Garbay, Valérie Daugé
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 370:404-413
Pharmacological studies were undertaken with a new series of cholecystokinin(2) CCK(2) agonists in order to assign to them a CCK(2A) or CCK(2B) pharmacological profile. The open-field test was chosen as the discrimination test of CCK(2B) agonists. Th
Autor:
Hervé Poras, Marie-Claude Fournie-Zaluski, Françoise Beslot, C. Bennejean, P. Renard, Nicolas Inguimbert, H. Dhotel, E. Scalbert, B.P. Roques
Publikováno v:
The Journal of Peptide Research. 63:99-107
Three zinc metallopeptidases are implicated in the regulation of fluid homeostasis and vascular tone and represent interesting targets for the treatment of chronic heart failure. We have previously reported the synthesis of a triple inhibitor able to
Autor:
Caroline Bennejean, Hervé Poras, Alain Tomas, Marie-Claude Fournie-Zaluski, Pierre Renard, Françoise Beslot, Nicolas Inguimbert, Mohamed Selkti, Elizabeth Scalbert, Bernard-Pierre Roques, Franck Teffo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2001-2005
We have previously reported the design of a lead compound 1a for the joint inhibition of neprilysin (NEP, EC 3.4.24.11), angiotensin converting enzyme (ACE, EC 3.4.15.1) and endothelin converting enzyme (ECE-1, EC 3.4.24.71), three metallopeptidases
Autor:
Toshimitsu Matsui, Bernard P. Roques, Matthieu Pophillat, Blandine Pommier, Florence Noble, Valérie Daugé, Françoise Beslot, Axelle Simon
Publikováno v:
Scopus-Elsevier
Stimulation of the brain CCK(2) receptor by the C-terminal octapeptide CCK(8) of cholecystokinin (CCK) negatively modulates opioid responses. This suggests the existence of physiologically relevant interactions between endogenous CCK and opioid pepti
Publikováno v:
Neuropsychopharmacology. 25:690-698
CCK2 receptor-deficient mice were used to investigate in vivo the role of this receptor in behavior. Mutant mice showed a neuromuscular impairment in the traction and rotarod tests but not in the chimney test. Brain cholecystokinin has been shown to
Publikováno v:
Neuroscience Letters. 306:41-44
Cholecystokinin2 (CCK2) receptor-deficient mice were used to analyze the in vivo function of CCK2 receptor and especially the incidence of this gene invalidation on enkephalinergic and dopaminergic systems. Hyperlocomotor activity of CCK2 receptor-de
Autor:
Bernard P. Roques, Françoise Beslot, Florence Noble, Olga Valverde, Valérie Daugé, Marie-Claude Fournie-Zaluski
Publikováno v:
European Journal of Neuroscience. 13:1816-1824
Recent studies have suggested that cannabinoids might initiate the consumption of other highly addictive substances, such as opiates. In this work, we show that acute administration of Delta9-tetrahydrocannabinol in mice facilitates the antinocicepti
Autor:
Nicole Defer, Rafael Maldonado, Magdalena Mas, Cedric Firmo, Jacques Hanoune, Françoise Beslot, Bernard P. Roques, Eleni T. Tzavara, Emmanuel Valjent
Publikováno v:
European Journal of Neuroscience. 12:1038-1046
Region-specific up-regulation of the cyclic AMP pathway is considered an important molecular mechanism in the origin of the somatic manifestations of the withdrawal syndrome to known drugs of abuse. Nevertheless, the existence of a withdrawal syndrom
Publikováno v:
European Journal of Neuroscience. 12:533-539
CB1 cannabinoid receptors are widely distributed in the central nervous system where they mediate most of the cannabinoid-induced responses. Here we have evaluated the interactions between the CB1 cannabinoid receptors and the endogenous opioid syste
Autor:
Valérie Daugé, Alain Regnault, Claude Rouch, Martine Orosco, Françoise Beslot, Sebastien Feurté
Publikováno v:
Behavioural brain research. 148(1-2)
Among food proteins, alpha-lactalbumin (LAC) has the highest ratio of tryptophan (Trp) over its competitor amino acids. Consequently, contrary to casein (CAS), LAC ingestion increases Trp access to the brain leading to enhanced serotonin (5-HT) synth