Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Françoise, Richard"'
Targeting CEACAM5-positive solid tumors using NILK-2401, a novel CEACAM5xCD47 κλ bispecific antibody
Autor:
Anja Seckinger, Vanessa Buatois, Valéry Moine, Bruno Daubeuf, Françoise Richard, Laurence Chatel, Alizée Viandier, Nicolas Bosson, Emeline Rousset, Krzysztof Masternak, Susana Salgado-Pires, Claudia Batista, Christelle Mougin, Flora Juan-Bégeot, Yves Poitevin, Dirk Hose
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundBlocking the CD47 “don’t eat me”-signal on tumor cells with monoclonal antibodies or fusion proteins has shown limited clinical activity in hematologic malignancies and solid tumors thus far. Main side effects are associated with non-
Externí odkaz:
https://doaj.org/article/54cec0396f744440a1e37f2a5e4704e8
Autor:
Walter Ferlin, Stéphanie Hugues, Xavier Chauchet, Elise Pernarrieta, Nicolas Bosson, Sébastien Calloud, Louis Hellequin, Margaux Legrand, Alizée Viandier, Françoise Richard, Laura Cons, Pauline Malinge, Tereza Bautzova, Jérémie Bourguignon, Guillemette Pontini, Mengzhu Sun, Ulla Ravn, Valéry Moine, Yves Poitevin, Nicolas Fischer, Limin Shang, Krzysztof Masternak
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/fd883ac37182497abd025cc9848e0fb7
Autor:
Eric Hatterer, Xavier Chauchet, Françoise Richard, Leticia Barba, Valéry Moine, Laurence Chatel, Lucile Broyer, Guillemette Pontini, Tereza Bautzova, Flora Juan, Sebastien Calloud, Nicolas Bosson, Maud Charreton, Krzysztof Masternak, Vanessa Buatois, Limin Shang
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Mesothelin (MSLN) is a cell surface glycoprotein overexpressed in several solid malignancies, including gastric, lung, mesothelioma, pancreatic and ovarian cancers. While several MSLN-targeting therapeutic approaches are in development, only limited
Externí odkaz:
https://doaj.org/article/59bc1e85e0ff4934aa2869af212e6158
Autor:
Walter G. Ferlin, Limin Shang, Nicolas Fischer, Krzysztof Masternak, Marie H. Kosco-Vilbois, John F. DiPersio, Michael Rettig, Julie Ritchey, Linda Eissenberg, Adele K. Fielding, Katharine Bailey, Aditi Dey, José María Ribera, Eulàlia Genescà Ferrer, Robert K. Clarke Hinojosa, Karin Tarte, Thierry Fest, Simon LeGallou, Thomas Matthes, Matilde D'Asaro, Lucile Broyer, Laura Cons, Bruno Daubeuf, Leticia Barba, Françoise Richard, Xavier Chauchet, Eric Hatterer, Anne Papaioannou, Susana Salgado-Pires, Zoë Johnson, Vanessa Buatois
CD47, an ubiquitously expressed innate immune checkpoint receptor that serves as a universal “don't eat me” signal of phagocytosis, is often upregulated by hematologic and solid cancers to evade immune surveillance. Development of CD47-targeted m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d1610faf183edfbabdd336c0a26e78f
https://doi.org/10.1158/1535-7163.c.6538060.v1
https://doi.org/10.1158/1535-7163.c.6538060.v1
Autor:
Walter G. Ferlin, Limin Shang, Nicolas Fischer, Krzysztof Masternak, Marie H. Kosco-Vilbois, John F. DiPersio, Michael Rettig, Julie Ritchey, Linda Eissenberg, Adele K. Fielding, Katharine Bailey, Aditi Dey, José María Ribera, Eulàlia Genescà Ferrer, Robert K. Clarke Hinojosa, Karin Tarte, Thierry Fest, Simon LeGallou, Thomas Matthes, Matilde D'Asaro, Lucile Broyer, Laura Cons, Bruno Daubeuf, Leticia Barba, Françoise Richard, Xavier Chauchet, Eric Hatterer, Anne Papaioannou, Susana Salgado-Pires, Zoë Johnson, Vanessa Buatois
Supplementary Table S5 shows the hematological results of cynomolgus monkeys treated with vehicle (Ctr.) or NI-1701 (Treat.) at 30 and 100 mg/kg over 4 weeks.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203cc77da9079bee1c610c03ee5b49e7
https://doi.org/10.1158/1535-7163.22505443.v1
https://doi.org/10.1158/1535-7163.22505443.v1
Autor:
Walter G. Ferlin, Limin Shang, Nicolas Fischer, Krzysztof Masternak, Marie H. Kosco-Vilbois, John F. DiPersio, Michael Rettig, Julie Ritchey, Linda Eissenberg, Adele K. Fielding, Katharine Bailey, Aditi Dey, José María Ribera, Eulàlia Genescà Ferrer, Robert K. Clarke Hinojosa, Karin Tarte, Thierry Fest, Simon LeGallou, Thomas Matthes, Matilde D'Asaro, Lucile Broyer, Laura Cons, Bruno Daubeuf, Leticia Barba, Françoise Richard, Xavier Chauchet, Eric Hatterer, Anne Papaioannou, Susana Salgado-Pires, Zoë Johnson, Vanessa Buatois
Supplementary material and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b418cfd8466c7d5dc25c91df055d57f2
https://doi.org/10.1158/1535-7163.22505458.v1
https://doi.org/10.1158/1535-7163.22505458.v1
Autor:
Walter G. Ferlin, Limin Shang, Nicolas Fischer, Krzysztof Masternak, Marie H. Kosco-Vilbois, John F. DiPersio, Michael Rettig, Julie Ritchey, Linda Eissenberg, Adele K. Fielding, Katharine Bailey, Aditi Dey, José María Ribera, Eulàlia Genescà Ferrer, Robert K. Clarke Hinojosa, Karin Tarte, Thierry Fest, Simon LeGallou, Thomas Matthes, Matilde D'Asaro, Lucile Broyer, Laura Cons, Bruno Daubeuf, Leticia Barba, Françoise Richard, Xavier Chauchet, Eric Hatterer, Anne Papaioannou, Susana Salgado-Pires, Zoë Johnson, Vanessa Buatois
Supplementary Figure S1 shows shows the percentage of in vitro phagocytosis of Raji cells by macrophages with NI-1701 or CD19/CD47hi biAb.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592d616e34724f770f64888467e08599
https://doi.org/10.1158/1535-7163.22505464
https://doi.org/10.1158/1535-7163.22505464
Autor:
Walter G. Ferlin, Limin Shang, Nicolas Fischer, Krzysztof Masternak, Marie H. Kosco-Vilbois, John F. DiPersio, Michael Rettig, Julie Ritchey, Linda Eissenberg, Adele K. Fielding, Katharine Bailey, Aditi Dey, José María Ribera, Eulàlia Genescà Ferrer, Robert K. Clarke Hinojosa, Karin Tarte, Thierry Fest, Simon LeGallou, Thomas Matthes, Matilde D'Asaro, Lucile Broyer, Laura Cons, Bruno Daubeuf, Leticia Barba, Françoise Richard, Xavier Chauchet, Eric Hatterer, Anne Papaioannou, Susana Salgado-Pires, Zoë Johnson, Vanessa Buatois
Video 1 shows the real time phagocytosis of cancer cells in presence of NI-1701
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03b6ea47ab39912f01a7fe54bdc4554
https://doi.org/10.1158/1535-7163.22505440.v1
https://doi.org/10.1158/1535-7163.22505440.v1
Autor:
Walter G. Ferlin, Limin Shang, Nicolas Fischer, Krzysztof Masternak, Marie H. Kosco-Vilbois, John F. DiPersio, Michael Rettig, Julie Ritchey, Linda Eissenberg, Adele K. Fielding, Katharine Bailey, Aditi Dey, José María Ribera, Eulàlia Genescà Ferrer, Robert K. Clarke Hinojosa, Karin Tarte, Thierry Fest, Simon LeGallou, Thomas Matthes, Matilde D'Asaro, Lucile Broyer, Laura Cons, Bruno Daubeuf, Leticia Barba, Françoise Richard, Xavier Chauchet, Eric Hatterer, Anne Papaioannou, Susana Salgado-Pires, Zoë Johnson, Vanessa Buatois
Video 2 shows the real time phagocytosis of cancer cells in presence of hIgG1 control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76705390add379177b660b6a299aec9
https://doi.org/10.1158/1535-7163.22505437.v1
https://doi.org/10.1158/1535-7163.22505437.v1
Autor:
Bruno Daubeuf, Benoit von der Weid, Eric Hatterer, Jean-Pierre Aubry-Lachainaye, Leticia Barba, Nelly Noraz, Françoise Richard, Vanessa Buatois, Walter Ferlin, Limin Shang, Marie Kosco-Vilbois
Publikováno v:
mAbs
CD19 is a B cell-specific receptor that regulates the threshold of B cell receptor (BCR)-mediated cell proliferation. A CD47xCD19 bispecific antibody (biAb) was generated to target and deplete B cells via multiple antibody-mediated mechanisms. Intere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a5ad176259a7e5ee05caa5afb7513f
https://doi.org/10.1080/19420862.2018.1558698
https://doi.org/10.1080/19420862.2018.1558698