Phenotypic Adaptation of Pseudomonas aeruginosa in the Presence of Siderophore-Antibiotic Conjugates during Epithelial Cell Infection

Autor: Quentin Perraud, Paola Cantero, Mathilde Munier, Françoise Hoegy, Nicolas Zill, Véronique Gasser, Gaëtan L. A. Mislin, Laurence Ehret-Sabatier, Isabelle J. Schalk

Publikováno v: Microorganisms, Vol 8, Iss 11, p 1820 (2020)

Iron acquisition pathways have often been considered to be gateways for the uptake of antibiotics into bacteria. Bacteria excrete chelators, called siderophores, to access iron. Antibiotic molecules can be covalently attached to siderophores for thei

Externí odkaz: https://doaj.org/article/e8a9311ad2074f619f3a9dec1b99484a

Dipyridylamine-acetamide (Dpaa): A primary amine protecting group orthogonally cleavable under acidic conditions in the presence of t-butyloxycarbonyl (Boc) and t-butylester

Autor: Aline L. Faucon, Françoise Hoegy, Noémie Werle, Christophe Gourlaouen, Gaëtan L.A. Mislin

Publikováno v: Tetrahedron Letters. 96:153758

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40fe7661903ec3bd7f060f56e03c399f
https://doi.org/10.1016/j.tetlet.2022.153758

Iron Release from the Siderophore Pyoverdine in Pseudomonas aeruginosa Involves Three New Actors: FpvC, FpvG, and FpvH

Autor: Françoise Hoegy, Béatrice Roche, Véronique Gasser, Isabelle J. Schalk, Beata Basta, Karl Brillet, Géraldine Ganne

Publikováno v: ACS Chemical Biology
ACS Chemical Biology, American Chemical Society, 2017, 12 (4), pp.1056-1065. ⟨10.1021/acschembio.6b01077⟩

Siderophores are iron chelators produced by bacteria to access iron, an essential nutriment. Pyoverdine (PVDI), the major siderophore produced by Pseudomonas aeruginosa PAO1, consists of a fluorescent chromophore linked to an octapeptide. The ferric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a616aaf522d7ab031ac3ec025906825
https://doi.org/10.1021/acschembio.6b01077

Synthesis of conjugates between oxazolidinone antibiotics and a pyochelin analogue

Autor: Françoise Hoegy, Béatrice Roche, Gaëtan L. A. Mislin, Isabelle J. Schalk, Aurélie Paulen

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2017, 27 (21), pp.4867-4870. ⟨10.1016/j.bmcl.2017.09.039⟩

Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium responsible for severe infections, and it is naturally resistant to many clinically approved antibiotic families. Oxazolidinone antibiotics are active against many Gram-positive bacteria,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fbd36edcaba62c28cece50f18aff29
https://pubmed.ncbi.nlm.nih.gov/28947150

The PvdRT-OpmQ efflux pump controls the metal selectivity of the iron uptake pathway mediated by the siderophore pyoverdine in Pseudomonas aeruginosa

Autor: Françoise Hoegy, Mélissa Hannauer, Pascale Ronot, Anne Boos, Isabelle J. Schalk, Armelle Braud

Publikováno v: Environmental Microbiology. 14:1696-1708

Summary Pyoverdine (PVD) is the major siderophore produced by Pseudomonas aeruginosa for iron acquisition. PvdRT-OpmQ is an ATP-dependent efflux pump involved in the secretion of newly synthesized pyoverdine (PVD) and of PVD that has transported and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b858de9f3b4eb509ce1d730fcca7917d
https://doi.org/10.1111/j.1462-2920.2011.02674.x