Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Françoise, Heymans"'
Autor:
Jean-Edouard Ombetta, Natacha Thelier, Chang Zhi Dong, Stéphanie Plocki, Lydia Tsagris, François Rannou, France Massicot, Atimé Djimdé, Elissar El-Hayek, Yiming Shi, Françoise Heymans, Nohad Gresh, Caroline Chauvet
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10914 (2010)
Group IIA secreted/synovial phospholipase A(2) (GIIAPLA(2)) is an enzyme involved in the synthesis of eicosanoids such as prostaglandin E(2) (PGE(2)), the main eicosanoid contributing to pain and inflammation in rheumatic diseases. We designed, by mo
Externí odkaz:
https://doaj.org/article/08b29ccca8db43b08730c735e6c9c05e
Autor:
Chang-Ha Park, Aazdine Lamouri, Atimé Djimdé, Joo-Hyoung Yoon, Nadia Meddad-Belhabich, Latifa Boukli, Mohamed Touaibia, Jung-Joo Kim, Françoise Heymans
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:1242-1253
Among the different PLA2s identified to date, the group IIA secretory PLA2 (sPLA2 GIIA) is implied in diverse pathological conditions. In this work we describe the synthesis, inhibitory activities, and structure–activity relationships (SAR) of a ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7e0bc0fe66e6713e9771738af8008b
https://doi.org/10.1016/j.bmc.2007.10.077
https://doi.org/10.1016/j.bmc.2007.10.077
Publikováno v:
European Journal of Organic Chemistry. 2008:299-307
Two novel classes of 4-aminopiperidines substituted in the 3-position by groups bearing either a carbamate or a ureido function have been synthesized from ethyl 4-oxo-3-piperidinecarboxylate and 3,3′-iminobis(propanenitrile), respectively. The key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d989528dd084caa0b9c5c3b83fd0e2a
https://doi.org/10.1002/ejoc.200700667
https://doi.org/10.1002/ejoc.200700667
Autor:
Nathalie Dereuddre-Bosquet, Françoise Heymans, Wafa Sallem, Catherine Redeuilh, Nawal Serradji, Houcine Benmehdi, Marc Martin, Georges Dive, Okkacha Bensaid, Aazdine Lamouri, Pascal Clayette
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:8109-8125
HIV-1 infection of the brain and PAF neurotoxicity are implicated in AIDS dementia complex. We previously reported that a trisubstituted piperazine derivative is able to diminish both HIV-1 replication in monocyte-derived macrophages and PAF-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b445cb3949bd57cb076c1ee46f9b186
https://doi.org/10.1016/j.bmc.2006.07.031
https://doi.org/10.1016/j.bmc.2006.07.031
Autor:
Miezan J.-M. Ezoulin, Juan Li, Guirong Wu, Chang-Zhi Dong, Jean-Edouard Ombetta, Hong-Zhuan Chen, France Massicot, Françoise Heymans
Publikováno v:
Neuroscience Letters. 389:61-65
In the search for highly selective and potent cholinesterase inhibitors (AChEI) being able to improve oxidative injury, PMS777, a tetrahydrofuran derivative, was designed as a novel dual PAF and acetylcholinesterase inhibitor. The aim of this study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e5d79650f4ced30bf424acf90dcacd
https://doi.org/10.1016/j.neulet.2005.07.026
https://doi.org/10.1016/j.neulet.2005.07.026
Autor:
Nadia Meddad-Bel Habich, Jean-Edouard Ombetta, Aazdine Lamouri, Françoise Heymans, Léon Assogba, Azali Ahamada-Himidi, Chang-Zhi Dong, Jean-Jacques Godfroid, Darina Aoun, Jack Huet, Latifa Boukli, Carine Mounier
Publikováno v:
European Journal of Medicinal Chemistry. 40:850-861
Starting from 4-tetradecyloxybenzamidine ( PMS815 ), a non-specific inhibitor of GI and GII PLA 2 s, we report in this work the discovery of the specificity through design, synthesis and structure–activity relationships studies of different kinds o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344bd152866c9acc1617d8c4905d47c3
https://doi.org/10.1016/j.ejmech.2005.03.027
https://doi.org/10.1016/j.ejmech.2005.03.027
Autor:
Stéphanie Plocki, Darina Aoun, Azali Ahamada-Himidi, Fernanda Tavarès-Camarinha, Chang-Zhi Dong, France Massicot, Jack Huet, Sylvie Adolphe-Pierre, François Chau, Jean-Jacques Godfroid, Nohad Gresh, Jean Edouard Ombetta, Françoise Heymans
Publikováno v:
European Journal of Organic Chemistry. 2005:2747-2757
3-(4-Tetradecyloxybenzyl)-4H-1,2,4-oxadiazol-5-one (PMS1062 or I) can probably act as a PLA2-II inhibitor on the acute inflammation model, but its highly lipophilic character could prevent it from being biodistributed effectively. In this work, based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2907849bd2cff3ea49fcf945e4a99b0d
https://doi.org/10.1002/ejoc.200400541
https://doi.org/10.1002/ejoc.200400541
Autor:
G. Le Pavec, Marc Martin, Nathalie Dereuddre-Bosquet, G. Fichet, Françoise Heymans, Nawal Serradji, Dominique Dormont, J. J. Godfroid, Aazdine Lamouri, Pascal Clayette
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:3150-3154
We assessed the anti-human immunodeficiency virus (anti-HIV) activity in vitro of new platelet-activating factor (PAF) receptor antagonists, as PAF and viral replication are thought to be involved in HIV neuropathogenesis. We found that PMS-601 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84c531096ddb67f1e057c70b9f0ea42
https://doi.org/10.1128/aac.44.11.3150-3154.2000
https://doi.org/10.1128/aac.44.11.3150-3154.2000
Autor:
Jack Huet, Marc Martin, Okkacha Bensaid, Erwan Kan, Dominique Dormont, Nathalie Dereuddre-Bosquet, Catherine Redeuilh, Nawal Serradji, Chang-Zhi Dong, Aazdine Lamouri, Pascal Clayette, Jean-Jacques Godfroid, Françoise Heymans
Publikováno v:
Journal of Medicinal Chemistry. 43:2149-2154
Excessive levels of PAF and cells of macrophage lineage appear to play an important role in neuronal cell injury, inflammatory syndrome, and HIV replication in CNS resulting in AIDS dementia complex (ADC). The beneficial effects of PAF receptor antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcb0491e61c3858ec4aa5f891a0f74f
https://doi.org/10.1021/jm9911276
https://doi.org/10.1021/jm9911276
Autor:
Georges Dive, Estera Touboul, Nicole Blavet, Aazdine Lamouri, Fabrice Tavet, Françoise Heymans, Jean-Jacques Godfroid
Publikováno v:
Journal of Lipid Mediators and Cell Signalling. 15:145-159
In the continuation of our investigations on the structure of platelet-activating factor (PAF)-receptor, 25 additional 2-substituted 1,4-bis-(poly- and mono methoxybenzoyl)-piperazines were synthesized and their in vitro biological activities measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63179c1f5810fd19d6f2cf527461a58f
https://doi.org/10.1016/s0929-7855(96)00551-2
https://doi.org/10.1016/s0929-7855(96)00551-2