Synthesis and Antiproliferative Effect of 3,4,5-Trimethoxylated Chalcones on Colorectal and Prostatic Cancer Cells

Autor: Cécile Letulle, François-Xavier Toublet, Aline Pinon, Soufyane Hba, Aurélie Laurent, Vincent Sol, Catherine Fagnère, Benjamin Rioux, Florent Allais, Sophie Michallet, Laurence Lafanechère, Youness Limami, Mounia Oudghiri, Mohamed Othman, Adam Daïch, Bertrand Liagre, Ata Martin Lawson, Christelle Pouget

Publikováno v: Pharmaceuticals, Vol 17, Iss 9, p 1207 (2024)

In the context of designing innovative anticancer agents, the synthesis of a series of chalcones bearing a 3,4,5-trimethoxylated A ring and a variety of B rings, including phenols and original heterocycles such as chromones, was conducted. For this e

Externí odkaz: https://doaj.org/article/bcc1be4f4ae54c15861b7cb9f5906914

Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease

Autor: Thomas Freret, Michel Boulouard, Audrey Davis, Marc Since, Bérénice Hatat, Sylvie Claeysen, François-Xavier Toublet, Patrick Dallemagne, Julien Lalut, Jana Sopkova-de Oliveira Santos, Sophie Corvaisier, Christophe Rochais, Cédric Lecoutey

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩
European Journal of Medicinal Chemistry, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩

International audience; Beside acetylcholinesterase, butyrylcholinesterase could be considered as a putative target of interest for the symptomatic treatment of Alzheimer's disease (AD). As a result of complexity of AD, no molecule has been approved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa2b8af7388914a57c9b97ea2cbffa1
https://hal.archives-ouvertes.fr/hal-03082877

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease

Autor: Patrick Dallemagne, François-Xavier Toublet, Julien Lalut, Marc Since, Bérénice Hatat, Cédric Lecoutey, Thomas Freret, Jana Sopkova-de Oliveira Santos, Christophe Rochais, Audrey Davis, Sophie Corvaisier, Sylvie Claeysen, Michel Boulouard

Publikováno v: Molecules
Molecules, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩
Molecules, MDPI, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩
Molecules, Vol 24, Iss 15, p 2786 (2019)
Volume 24
Issue 15

Alzheimer&rsquo
s disease (AD) is a multifactorial neurodegenerative disease which is still poorly understood. The drugs currently used against AD, mainly acetylcholinesterase inhibitors (AChEI), are considered clinically insufficient and are re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9719db0b6c84605d8c5d20ffff9b445
https://hal.science/hal-02399906/document