Seven Pillars of Small Airways Disease in Asthma and COPD

Autor: Naimish Patel, James C. Hogg, Megan Hardin, Stephen I. Rennard, Omar S. Usmani, Mary N. Brown, François-Xavier Blé, Christina Keen, MeiLan K. Han, David A. Kaminsky, Josephine Hjoberg

Publikováno v: Chest. 160:114-134

Identification of pathologic changes in early and mild obstructive lung disease has shown the importance of the small airways and their contribution to symptoms. Indeed, significant small airways dysfunction has been found prior to any overt airway o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b426f584a78ef2e5a302e533fb8af460
https://doi.org/10.1016/j.chest.2021.03.047

Response

Autor: Omar S, Usmani, MeiLan K, Han, David A, Kaminsky, James, Hogg, Josephine, Hjoberg, Naimish, Patel, Megan, Hardin, Christina, Keen, Stephen, Rennard, François-Xavier, Blé, Mary N, Brown

Publikováno v: Chest. 161:e249-e250

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df43a290b3d112590c16e6482455b0dd
https://doi.org/10.1016/j.chest.2021.12.643

Modeling Gadoxetate Liver Uptake and Efflux Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging Enables Preclinical Quantification of Transporter Drug-Drug Interactions

Autor: Penny L. Hubbard Cristinacce, Neil Woodhouse, Josephine H. Naish, Glynis Nicholls, Jeffrey Penny, Leonidas Georgiou, François-Xavier Blé

Publikováno v: Investigative Radiology. 53:563-570

The aim of this study was to model the in vivo transporter-mediated uptake and efflux of the hepatobiliary contrast agent gadoxetate in the liver. The efficacy of the proposed technique was assessed for its ability to provide quantitative insights in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3568eea58b89100b0a83ac1544837e2
https://doi.org/10.1097/rli.0000000000000480

Quantitative Assessment of Mucociliary Clearance in Smokers with Mild-to-Moderate Chronic Obstructive Pulmonary Disease and Chronic Bronchitis from Planar Radionuclide Imaging Using the Change in Penetration Index

Autor: Michael J. Bennett, John S. Fleming, Mats Carlsson, Joy Conway, Eva Bondesson, Christopher McCrae, François-Xavier Blé, Matthew Guy, Livia Tossici-Bolt

Publikováno v: Journal of aerosol medicine and pulmonary drug delivery. 32(4)

Background: Mucociliary clearance (MCC) rate from the lung has been shown to be reduced in chronic obstructive pulmonary disease (COPD). This study compared the use of change in penetration index (PI) with conventional whole lung clearance in assessi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86428ec11579c9c36a64049e495f8599
https://pubmed.ncbi.nlm.nih.gov/30848685

Quantitative Assessment of Liver Function Using Gadoxetate-Enhanced Magnetic Resonance Imaging:Monitoring Transporter-Mediated Processes in Healthy Volunteers

Autor: Penny L. Hubbard Cristinacce, Leonidas Georgiou, Josephine H. Naish, Neil Woodhouse, Jeffrey Penny, Glynis Nicholls, François-Xavier Blé

Publikováno v: Georgiou, L, Penny, J, Nicholls, G, Woodhouse, N, Blé, F-X, Hubbard Cristinacce, P L & Naish, J H 2017, ' Quantitative Assessment of Liver Function Using Gadoxetate-Enhanced Magnetic Resonance Imaging : Monitoring Transporter-Mediated Processes in Healthy Volunteers ' Invest Radiol, vol 52, no. 2, pp. 111-119 . DOI: 10.1097/RLI.0000000000000316
Georgiou, L, Penny, J, Nicholls, G, Woodhouse, N, Blé, F-X, Hubbard Cristinacce, P L & Naish, J H 2017, ' Quantitative assessment of liver function using Gadoxetate-Enhanced Magnetic Resonance Imaging : Monitoring Transporter-Mediated processes in healthy volunteers ', Investigative Radiology, vol. 52, no. 2, pp. 111-119 . https://doi.org/10.1097/RLI.0000000000000316
Investigative Radiology

OBJECTIVE: The objective of this study was to use noninvasive dynamic contrast-enhanced magnetic resonance imaging (MRI) techniques to study, in vivo, the distribution and elimination of the hepatobiliary contrast agent gadoxetate in the human body a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80768a12cb384a361a6fc9d228256b8a
https://www.research.manchester.ac.uk/portal/en/publications/quantitative-assessment-of-liver-function-using-gadoxetateenhanced-magnetic-resonance-imaging(13037927-da7d-4d6e-a2a8-a656aba817f7).html