Zobrazeno 1 - 10
of 33
pro vyhledávání: '"François Vandenhende"'
Autor:
Jean-Jacques Garaud, Marc Derive, Xavier Wittebole, François Vandenhende, Thierry Dugernier, Valerie Cuvier, Peter Pickkers, Stephan Witte, Miguel Angel Gomez Sanchez, Margarita Salcedo-Magguilli, Aurelie Olivier, Bruno François, Jean-Paul Mira, Ricard Ferrer, Pierre-François Laterre, Sébastien Gibot
Publikováno v:
Intensive Care Medicine, 46, 7, pp. 1425-1437
Intensive Care Medicine, 46, 1425-1437
Intensive Care Medicine, 46, 1425-1437
Contains fulltext : 225478.pdf (Publisher’s version ) (Closed access) PURPOSE: Nangibotide is a specific TREM-1 inhibitor that tempered deleterious host-pathogens interactions, restored vascular function, and improved survival, in animal septic sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca247fb196374419e08bdd6f9f6cfc9
https://doi.org/10.1007/s00134-020-06109-z
https://doi.org/10.1007/s00134-020-06109-z
Autor:
Mohini Ranganathan, Johannes Tauscher, Jim Ropchan, Robert Bell, Alexander Neumeister, Yiyun Huang, Shannan Henry, Jennifer Witcher, Gemma L Dickinson, Ming-Qiang Zheng, Richard E. Carson, Mika Naganawa, François Vandenhende, Shu-fei Lin, Nabeel Nabulsi
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 356:260-266
The κ-opioid receptor (KOR) is thought to play an important therapeutic role in a wide range of neuropsychiatric and substance abuse disorders, including alcohol dependence. LY2456302 is a recently developed KOR antagonist with high affinity and sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb4ada5247016e62da96fe244717a20
https://doi.org/10.1124/jpet.115.229278
https://doi.org/10.1124/jpet.115.229278
Autor:
Johannes Tauscher, Smriti Iyengar, Gerard J. Marek, William Kielbasa, David Mozley, François Vandenhende, Xiaomei Peng, Donald R. Gehlert
Publikováno v:
European Neuropsychopharmacology. 20:80-87
The neurokinin-1 (NK-1) antagonist LY686017 showed activity in preclinical anxiety models. The clinical development of LY686017 included a PET study and a proof-of-concept in social anxiety disorder (SAD). [ 11 C]GR205171 was used healthy volunteers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2362d55efa3845848c312a89a550990
https://doi.org/10.1016/j.euroneuro.2009.10.005
https://doi.org/10.1016/j.euroneuro.2009.10.005
Autor:
Philippe Lambert, François Vandenhende
Publikováno v:
Statistics & Probability Letters. 63:157-163
We extend rank-based dependence measures like Spearman's rho to categorical data so that the same 1 limits are always reached under complete dependence. A goodness-of-fit procedure is derived for dependence models using copulas. (C) 2003 Elsevier Sci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0c7eee179d16d79a0f57db7a69eebe5
https://doi.org/10.1016/s0167-7152(03)00063-4
https://doi.org/10.1016/s0167-7152(03)00063-4
Publikováno v:
Pharmaceutical Statistics. 2:199-210
Specific efficacy criteria were defined by the International Headache Society for controlled clinical trials on acute migraine. They are derived from the pain profile and the timing of rescue medication intake. We present a methodology to improve the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba45faabc829dfb8182633ef82dfc86f
https://doi.org/10.1002/pst.61
https://doi.org/10.1002/pst.61
Autor:
François Vandenhende
Publikováno v:
Drug Information Journal. 35:1179-1188
In toxicity studies, the ECG is recorded over a range of escalating doses and the assessment of QT prolongation is made by comparing treated to untreated animals. As the QT interval and heart rate are inversely related, any imbalance in the distribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f04b73a22cbc51707f9f733d69ff27e
https://doi.org/10.1177/009286150103500415
https://doi.org/10.1177/009286150103500415
Publikováno v:
Drug Information Journal. 34:411-419
Bilateral pharmacokinetic interaction studies are performed to rest if the coadministration of the two drugs alters the kinetics of either one. For this purpose, standard designs are crossovers in which the two drugs are successively given alone and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::977c0ce38c38d86bfd336020f99c44d2
https://doi.org/10.1177/009286150003400209
https://doi.org/10.1177/009286150003400209
Autor:
Wherly P. Hoffman, François Vandenhende, Bruno Boulanger, Walthère Dewé, Marie-Helene Delsemme, Muriel Comblain
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 27:191-212
Based on toxicokinetic studies of a destructive sampling design, this work was aimed at selecting the number of time points, their locations, and the number of replicates per time point in order to obtain the most accurate and precise noncompartmenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de75f914ff5337839e85e051e669367b
https://doi.org/10.1023/a:1020606006936
https://doi.org/10.1023/a:1020606006936
Autor:
Susan Baird-Bellaire, Nagaraju Poola, Jeffrey Paul, Hong Wan, Philippe Danjou, Anna Plotka, François Vandenhende, Stephan Chalon
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b20c20ea910f8fc1dae9df70217e3fc4
https://doi.org/10.1016/j.jalz.2010.05.1702
https://doi.org/10.1016/j.jalz.2010.05.1702
Publikováno v:
Pharmaceutical statistics. 8(2)
In preclinical and clinical experiments, pharmacokinetic (PK) studies are designed to analyse the evolution of drug concentration in plasma over time i.e. the PK profile. Some PK parameters are estimated in order to summarize the complete drug's kine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77eeecc02f9f3a96c9ac31203b6b1034
https://pubmed.ncbi.nlm.nih.gov/18481279
https://pubmed.ncbi.nlm.nih.gov/18481279