Výsledky vyhledávání - "François Sichel"

Akademický článek

Differential normal skin transcriptomic response in total body irradiated mice exposed to scattered versus scanned proton beams

Autor: Alexandre Leduc, Samia Chaouni, Frédéric Pouzoulet, Ludovic De Marzi, Frédérique Megnin-Chanet, Erwan Corre, Dinu Stefan, Jean-Louis Habrand, François Sichel, Carine Laurent

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Proton therapy allows to avoid excess radiation dose on normal tissues. However, there are some limitations. Indeed, passive delivery of proton beams results in an increase in the lateral dose upstream of the tumor and active scanning leads

Externí odkaz: https://doaj.org/article/4a4f1e1463b84baf95bd357afe03d024

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Akademický článek

Publisher Correction: Differential normal skin transcriptomic response in total body irradiated mice exposed to scattered versus scanned proton beams

Autor: Alexandre Leduc, Samia Chaouni, Frédéric Pouzoulet, Ludovic De Marzi, Frédérique Megnin-Chanet, Erwan Corre, Dinu Stefan, Jean-Louis Habrand, François Sichel, Carine Laurent

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)

Externí odkaz: https://doaj.org/article/3cc80ce45bc94e10b484165d8147f1dc

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Akademický článek

Biological Effects of Scattered Versus Scanned Proton Beams on Normal Tissues in Total Body Irradiated Mice: Survival, Genotoxicity, Oxidative Stress and Inflammation

Autor: Samia Chaouni, Alexandre Leduc, Frédéric Pouzoulet, Ludovic De Marzi, Frédérique Megnin-Chanet, Dinu Stefan, Jean-Louis Habrand, François Sichel, Carine Laurent

Publikováno v: Antioxidants, Vol 9, Iss 12, p 1170 (2020)

Side effects of proton therapy are poorly studied. Moreover, the differences in the method of dose delivery on normal tissues are not taken into account when proton beams are scanned instead of being scattered. We proposed here to study the effects o

Externí odkaz: https://doaj.org/article/c975837669e045fbad6f6fe9ba4dfb02

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Akademický článek

The Possibility of Using Genotoxicity, Oxidative Stress and Inflammation Blood Biomarkers to Predict the Occurrence of Late Cutaneous Side Effects after Radiotherapy

Autor: Samia Chaouni, Delphine Dumont Lecomte, Dinu Stefan, Alexandre Leduc, Victor Barraux, Alexandra Leconte, Jean-Michel Grellard, Jean-Louis Habrand, Marilyne Guillamin, François Sichel, Carine Laurent

Publikováno v: Antioxidants, Vol 9, Iss 3, p 220 (2020)

Despite the progresses performed in the field of radiotherapy, toxicity to the healthy tissues remains a major limiting factor. The aim of this work was to highlight blood biomarkers whose variations could predict the occurrence of late cutaneous sid

Externí odkaz: https://doaj.org/article/4a7a0fc677c7444c846749cd24663d01

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Akademický článek

Dramatic increase in oxidative stress in carbon-irradiated normal human skin fibroblasts.

Autor: Carine Laurent, Alexandre Leduc, Ivannah Pottier, Virginie Prévost, François Sichel, Jean-Louis Lefaix

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e85158 (2013)

Skin complications were recently reported after carbon-ion (C-ion) radiation therapy. Oxidative stress is considered an important pathway in the appearance of late skin reactions. We evaluated oxidative stress in normal human skin fibroblasts after c

Externí odkaz: https://doaj.org/article/8b416ad976b1425eafd2173878117523

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Akademický článek

Benzo[a]pyrene, aflatoxine B₁ and acetaldehyde mutational patterns in TP53 gene using a functional assay: relevance to human cancer aetiology.

Autor: Vincent Paget, Mathilde Lechevrel, Véronique André, Jérémie Le Goff, Didier Pottier, Sylvain Billet, Guillaume Garçon, Pirouz Shirali, François Sichel

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e30921 (2012)

Mutations in the TP53 gene are the most common alterations in human tumours. TP53 mutational patterns have sometimes been linked to carcinogen exposure. In hepatocellular carcinoma, a specific G>T transversion on codon 249 is classically described as

Externí odkaz: https://doaj.org/article/67cf8bef1fc148ca87e1817fed6537ff

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Blood contamination of the pharmaceutical staff by irinotecan and its two major metabolites inside and outside a compounding unit

Autor: Stéphanie Lagadu, Victoire Béchet, Raphaël Delépée, Frédéric Beau, Fabienne Divanon, H Benoist, François Sichel, Guillaume Saint-Lorant

Publikováno v: Journal of Oncology Pharmacy Practice. 28:777-784

Background Caregivers in healthcare settings are exposed to a risk of antineoplastic drug contamination which can lead to adverse health effects. Biological monitoring is necessary to estimate the actual level of exposure of these workers. This study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5efcddf95b4e6e49779eb107a38c375
https://doi.org/10.1177/10781552211012059

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Differential normal skin transcriptomic response in total body irradiated mice exposed to scattered versus scanned proton beams

Autor: Frederic Pouzoulet, Jean-Louis Habrand, François Sichel, Alexandre Leduc, Ludovic De Marzi, Carine Laurent, Erwan Corre, Frédérique Mégnin-Chanet, Dinu Stefan, Samia Chaouni

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.5876. ⟨10.1038/s41598-021-85394-0⟩

Proton therapy allows to avoid excess radiation dose on normal tissues. However, there are some limitations. Indeed, passive delivery of proton beams results in an increase in the lateral dose upstream of the tumor and active scanning leads to strong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aafffdcc663f4291cfaf5c47d403aac
https://doaj.org/article/4a4f1e1463b84baf95bd357afe03d024

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