Screening Low-Frequency SNPS From Genome-Wide Association Study Reveals a New Risk Allele for Progression to AIDS

Autor: Philippe Froguel, Joshua T. Herbeck, Jean Louis Spadoni, Ping An, Sigrid Le Clerc, Olivier Delaneau, Jeremy J. Martinson, Matthieu Montes, Jan H. Veldink, François Schächter, Cheryl A. Winkler, Hanneke Schuitemaker, Leonard H. van den Berg, Safa Mellak, Taoufik Labib, Sophie Limou, Amu Therwath, James I. Mullins, Jean François Delfraissy, Lieng Taing, Daniëlle van Manen, Jean-François Zagury, Cédric Coulonges

Publikováno v: Journal of acquired immune deficiency syndromes (1999), 56(3), 279-284. Lippincott Williams and Wilkins

Background: Seven genome-wide association studies (GWAS) have been published in AIDS, and only associations in the HLA region on chromosome 6 and CXCR6 have passed genome-wide significance. Methods: We reanalyzed the data from 3 previously published

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4777f4e555669503b723a30347dbe5a6
https://doi.org/10.1097/qai.0b013e318204982b

Evidence after imputation for a role of MICA variants in nonprogression and elite control of HIV type 1 infection

Autor: Sigrid Le Clerc, Vincent Laville, Taoufik Labib, Jean-Louis Spadoni, François Schächter, Jean-François Zagury, Cédric Coulonges, Josselin Noirel, Sophie Caillat-Zucman, Damien Ulveling, Olivier Delaneau, Matthieu Montes

Publikováno v: The Journal of infectious diseases. 210(12)

Past genome-wide association studies (GWAS) involving individuals with AIDS have mainly identified associations in the HLA region. Using the latest software, we imputed 7 million single-nucleotide polymorphisms (SNPs)/indels of the 1000 Genomes Proje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997ba2e881c599023441f9ae8d87166f
https://pubmed.ncbi.nlm.nih.gov/24939907

A Model for Antagonistic Pleiotropic Gene Action for Mortality and Advanced Age

Autor: Bernard Godelle, François Schächter, Pierre-Henri Gouyon, Bruno Toupance

Publikováno v: American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), 1998, 62 (6), pp.1525-1534. ⟨10.1086/301865⟩

Summary Association or linkage studies involving control and long-lived populations provide information on genes that influence longevity. However, the relationship between allele-specific differences in survival and the genetic structure of aging co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0e5ad3a5ffad974ba642b90f216788
https://doi.org/10.1086/301865

Homeostasis of chemokines, interferon production and lymphocyte subsets: implications for AIDS pathogenesis

Autor: J Rappaport, Wolfgang Issing, A Astgen, Jean-François Zagury, Y.Y. Cho, François Schächter, JY Perrot, Houria Hendel

Publikováno v: Biomedicine & Pharmacotherapy. 51:221-229

Certain individuals with elevated levels of macrophage inflammatory protein (MIP)1 alpha, MIP1 beta and RANTES expression appear to be resistant to human immunodeficiency virus (HIV) infection. In this work, we demonstrate that chemokines production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4398d6ac8fe2dd1bff5e4d915f98ef4f
https://doi.org/10.1016/s0753-3322(97)81600-9

Contribution of cohort studies in understanding HIV pathogenesis: introduction of the GRIV cohort and preliminary results

Autor: N Gauthier, François Schächter, Jean-François Zagury, Houria Hendel, Y.Y. Cho, J Rappaport

Publikováno v: Biomedicine & Pharmacotherapy. 50:480-487

In the present paper we review studies performed on HIV-infected patients cohorts in order to understand AIDS disease development. The interplay between diverse factors such as the HIV envelope proteins, cellular co-receptors, the immune response wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d36c689abcd36984210aaa0e5aefaf
https://doi.org/10.1016/s0753-3322(97)89278-5