Zobrazeno 1 - 10
of 31
pro vyhledávání: '"François Sarra‐Bournet"'
Autor:
Dr. Boulos Zacharie, Dr. Shaun D. Abbott, Jean‐Simon Duceppe, Dr. Lyne Gagnon, Dr. Brigitte Grouix, Lilianne Geerts, Liette Gervais, François Sarra‐Bournet, Valérie Perron, Dr. Nicole Wilb, Dr. Christopher L. Penney, Pierre Laurin
Publikováno v:
ChemistryOpen, Vol 7, Iss 9, Pp 737-749 (2018)
Abstract Low‐molecular‐weight synthetic molecules 1 with the general 2‐(fluorophenylamino)‐4,6‐disubstituted 1,3,5‐triazine structure and showing anti‐inflammatory and anticancer activities were explored. Structure–activity relationsh
Externí odkaz:
https://doaj.org/article/d79c7adaeef745be869e6e9c100908b6
Autor:
Jugurtha Ouboudinar, Ramon Corpuz, Martin Leduc, Jean-Simon Duceppe, Alexandre Laverdure, Mikaël Tremblay, Kathy Hince, Amélie Blais, Marie-Pier Cloutier, Richard L. Hébert, Christopher R.J. Kennedy, Alexandra Blais, Liette Gervais, Lilianne Geerts, Lyne Gagnon, Pierre Laurin, Jean-Christophe Simard, Steven R. LaPlante, Sylvie Létourneau, Jean-Francois Thibodeau, François A. Leblond, Brigitte Grouix, Shaun D. Abbott, Boulos Zacharie, Alexandra Felton, Vanessa Marques Quintela, William Gagnon, François Sarra-Bournet
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Non-alcoholic Fatty Liver Disease (NAFLD) is the most common form of liver disease and is associated with metabolic dysregulation. Although G protein-coupled receptor 84 (GPR84) has been associated with inflammation, its role in metabolic regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7b27b3602799ec5543996bcf182aca
http://europepmc.org/articles/PMC7391726
http://europepmc.org/articles/PMC7391726
Autor:
Martin Kolb, Brigitte Grouix, F.A. Leblond, Chiko Shimbori, Toyoshi Yanagihara, Alexandra Felton, François Sarra-Bournet, Kjetil Ask, Mikaël Tremblay, Lyne Gagnon, M. Leduc
Publikováno v:
A68. PARENCHYMA/INTERSTITIAL LUNG DISEASE.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7b110c7ac9bbf60fa78126825e69b2f
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2389
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2389
Autor:
Shaun D. Abbott, Lyne Gagnon, Nicole Wilb, Valérie Perron, François Sarra-Bournet, Liette Gervais, Pierre Laurin, Brigitte Grouix, Lilianne Geerts, Christopher Penney, Jean-Simon Duceppe, Boulos Zacharie
Publikováno v:
ChemistryOpen, Vol 7, Iss 9, Pp 737-749 (2018)
Low‐molecular‐weight synthetic molecules 1 with the general 2‐(fluorophenylamino)‐4,6‐disubstituted 1,3,5‐triazine structure and showing anti‐inflammatory and anticancer activities were explored. Structure–activity relationship studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e01d3dc8d1768156e95629861145aea
https://doi.org/10.1002/open.201800136
https://doi.org/10.1002/open.201800136
Autor:
Jean-Francois Thibodeau, Alexandre Laverdure, Kathy Hince, Richard L. Hébert, Alex Gutsol, William Gagnon, Martin Leduc, Eldjonai Kamto, Liette Gervais, Shaun D. Abbott, Christopher R.J. Kennedy, Francois A. Leblond, Jonathan Richard, Pierre Laurin, Chet E. Holterman, Alexandra Felton, Ming-Zhi Zhang, François Sarra-Bournet, Mikaël Tremblay, Jugurtha Ouboudinar, Lilianne Geerts, Christopher Penney, Lyne Gagnon, Jocelyn Dupuis, Jean-Christophe Simard, Jean-Simon Duceppe, Quang Trinh Nguyen, Marie-Pier Cloutier, Raymond C. Harris, Angelino Calderone, Brigitte Grouix, Boulos Zacharie, Sylvie Létourneau
Publikováno v:
The American Journal of Pathology. 188:1132-1148
Numerous clinical conditions can lead to organ fibrosis and functional failure. There is a great need for therapies that could effectively target pathophysiological pathways involved in fibrosis. GPR40 and GPR84 are G protein–coupled receptors with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7315d43b6a70e40dd65fdef9ae6ea14c
https://doi.org/10.1016/j.ajpath.2018.01.009
https://doi.org/10.1016/j.ajpath.2018.01.009
Autor:
Brigitte Grouix, Jean-Christophe Simard, Jean-Francois Thibodeau, Mikaël Tremblay, Alexandre Laverdure, François Sarra-Bournet, Ramon Corpuz, Lyne Gagnon
Publikováno v:
Journal of Hepatology. 73:S656-S657
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d45f79a53697b31977a8a67667c5558
https://doi.org/10.1016/s0168-8278(20)31775-x
https://doi.org/10.1016/s0168-8278(20)31775-x
Autor:
François Sarra-Bournet, A. Laverdure, Alexandra Felton, Pierre Laurin, L. Gervais, M. Leduc, Brigitte Grouix, Mikaël Tremblay, A. Perreault, Lyne Gagnon
Publikováno v:
D107. MITOCHONDRIA AND ER STRESS IN HOMEOSTASIS AND REPAIR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36021bcedcd2f2d99c7e524dafe07eb4
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7231
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7231
Autor:
Marie-Pier Cloutier, François A. Leblond, Brigitte Grouix, Alexandre Laverdure, Mikaël Tremblay, Jonathan Richard, Liette Gervais, François Sarra-Bournet, Pierre Laurin, Alexandra Felton, Lyne Gagnon
Publikováno v:
Diabetes. 67
Introduction and Aims: Given the expected rise in the prevalence of obesity and type 2 diabetes, hepatic steatosis will, if not already, become an epidemic. The aim of this study was to determine the mechanism of action of PBI-4547 on diabetic compli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::545d834fba401e1a6f4a0a8990f1f160
https://doi.org/10.2337/db18-2000-p
https://doi.org/10.2337/db18-2000-p
Autor:
Alexandra Felton, Lyne Gagnon, Martin Leduc, Jean-Christophe Simard, Mikaël Tremblay, Liette Gervais, Pierre Laurin, François Sarra-Bournet, François A. Leblond, Brigitte Grouix
Publikováno v:
Diabetes. 67
Introduction and Aims: Obesity and its resulting metabolic disturbances are major health threats and are the main cause of a host of diseases, including nonalcoholic fatty liver disease (NAFLD). PBI-4547 is a novel first-in-class orally active antidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d968f78813aa1b467afd0f313a1ee89
https://doi.org/10.2337/db18-1858-p
https://doi.org/10.2337/db18-1858-p
Autor:
Mikaël Tremblay, William Gagnon, Martin Leduc, Marie-Pier Cloutier, Lyne Gagnon, François A. Leblond, Brigitte Grouix, François Sarra-Bournet, Jean-Christophe Simard, Pierre Laurin, Kathy Hince, Sylvie Létourneau
Publikováno v:
Diabetes. 67
Introduction: PBI-4547 is a novel orally active compound that is being developed for potential clinical use in patients suffering from metabolic and inflammatory/fibrosis-related diseases. This study examined the effect of PBI-4547 in NOD mice, a mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6346ba959877b8d9652ca33144b17a5e
https://doi.org/10.2337/db18-1817-p
https://doi.org/10.2337/db18-1817-p