Dissemination and transmission of the E1-226V variant of chikungunya virus in Aedes albopictus are controlled at the midgut barrier level.

Autor: Camilo Arias-Goeta, Laurence Mousson, François Rougeon, Anna-Bella Failloux

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57548 (2013)

Emergence of arboviruses could result from their ability to exploit new environments, for example a new host. This ability is facilitated by the high mutation rate occurring during viral genome replication. The last emergence of chikungunya in the In

Externí odkaz: https://doaj.org/article/45e559360f304ca185ac4ce54068db7a

Ectopic expression of AID in a non-B cell line triggers A:T and G:C point mutations in non-replicating episomal vectors.

Autor: Tihana Jovanic, Benjamin Roche, Géraldine Attal-Bonnefoy, Olivier Leclercq, François Rougeon

Publikováno v: PLoS ONE, Vol 3, Iss 1, p e1480 (2008)

Somatic hypermutation (SHM) of immunoglobulin genes is currently viewed as a two step process initiated by the deamination of deoxycytidine (C) to deoxyuridine (U), catalysed by the activation induced deaminase (AID). Phase 1 mutations arise from DNA

Externí odkaz: https://doaj.org/article/05aa149b921544268779bc6e2679ad5d

Deoxyuridine Triphosphate Incorporation during Somatic Hypermutation of Mouse VkOx Genes after Immunization with Phenyloxazolone

Autor: François Rougeon, Benjamin Roche, Aurélie Claës

Publikováno v: The Journal of Immunology. 185:4777-4782

Somatic hypermutation (SHM) of Ig genes is the result of a two-phase process initiated by activation-induced cytidine deaminase, relying on two different strategies for the introduction of mutations at CG pairs (phase I) and at AT pairs (phase II). T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20655d49de60cf1ec1ab876e407494ff
https://doi.org/10.4049/jimmunol.1001459

Identification of a new cis-regulatory element of the terminal deoxynucleotidyl transferase gene in the 5′ region of the murine locus

Autor: Martine Fanton d'Andon, Marie Cherrier, François Rougeon, Noëlle Doyen

Publikováno v: Molecular Immunology. 45:1009-1017

Terminal deoxynucleotidyl transferase (TdT) expression is controlled at the transcriptional level, however, the TdT core promoter combining D, D′, an initiator (Inr) and downstream basal elements (DBE) does not recapitulate the whole complex regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5adc11e872c94cec203f41fd37b1828
https://doi.org/10.1016/j.molimm.2007.07.027

Chikungunya virus adaptation to a mosquito vector correlates with only few point mutations in the viral envelope glycoprotein

Autor: Anna-Bella Failloux, Sara Moutailler, Karima Zouache, Laurence Mousson, Valérie Caro, François Rougeon, Camilo Arias-Goeta, Jean-Michel Thiberge

Publikováno v: Infection, Genetics and Evolution
Infection, Genetics and Evolution, Elsevier, 2014, 24, pp.116-126. ⟨10.1016/j.meegid.2014.03.015⟩
Infection, Genetics and Evolution; Vol 24
Infection, Genetics and Evolution, 2014, 24, pp.116-126. ⟨10.1016/j.meegid.2014.03.015⟩

International audience; Like most arthropod-borne viruses (arboviruses), chikungunya virus (CHIKV) is a RNA virus maintained in nature in an alternating cycle of replication between invertebrate and vertebrate hosts. It has been assumed that host alt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be070b1d4a1bdb73cc8dc7eb7d9f072d
https://hal-pasteur.archives-ouvertes.fr/pasteur-01717609