Zobrazeno 1 - 10
of 15
pro vyhledávání: '"François Pognan"'
Autor:
François Pognan, Chiara Buono, Philippe Couttet, Jean-René Galarneau, Yoav Timsit, Armin Wolf
Publikováno v:
Current Research in Toxicology, Vol 3, Iss , Pp 100091- (2022)
Sotuletinib (BLZ945), a CSF1-R specific kinase inhibitor developed for the treatment of Amyotrophic Lateral Sclerosis, induced liver enzyme elevation in absence of hepatocellular lesions in preclinical rat and monkey studies. The monocytic cell famil
Externí odkaz:
https://doaj.org/article/dc28d07b7f084f78b022a13a770acd1c
Autor:
François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Niklas Blomberg, Frank Bringezu, Katharine Briggs, Giulia Callegaro, Salvador Capella-Gutierrez, Emilio Centeno, Javier Corvi, Philip Drew, William C. Drewe, José M. Fernández, Laura I. Furlong, Emre Guney, Jan A. Kors, Miguel Angel Mayer, Manuel Pastor, Janet Piñero, Juan Manuel Ramírez-Anguita, Francesco Ronzano, Philip Rowell, Josep Saüch-Pitarch, Alfonso Valencia, Bob van de Water, Johan van der Lei, Erik van Mulligen, Ferran Sanz
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 237 (2021)
eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by usi
Externí odkaz:
https://doaj.org/article/6d356b4a5992408987f2d8a0131d3981
Autor:
Montserrat Cases, Katharine Briggs, Thomas Steger-Hartmann, François Pognan, Philippe Marc, Thomas Kleinöder, Christof H. Schwab, Manuel Pastor, Jörg Wichard, Ferran Sanz
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 11, Pp 21136-21154 (2014)
The high-quality in vivo preclinical safety data produced by the pharmaceutical industry during drug development, which follows numerous strict guidelines, are mostly not available in the public domain. These safety data are sometimes published as a
Externí odkaz:
https://doaj.org/article/7a907e1dda6a465797e0759489e8220b
Autor:
Jörg D. Wichard, Thomas Steger-Hartmann, Andreas Sutter, David K. Watson, Manuel Pastor, François Pognan, Ferran Sanz, Christof H. Schwab, David J. Heard, Montserrat Cases, Katharine Briggs
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 3, Pp 3820-3846 (2012)
There is a widespread awareness that the wealth of preclinical toxicity data that the pharmaceutical industry has generated in recent decades is not exploited as efficiently as it could be. Enhanced data availability for compound comparison (“read-
Externí odkaz:
https://doaj.org/article/ec609ff085e0487fa4342a7d028382c1
Autor:
Caterina Vacchi-Suzzi, Yasmina Bauer, Brian R Berridge, Sandrine Bongiovanni, Kevin Gerrish, Hisham K Hamadeh, Martin Letzkus, Jonathan Lyon, Jonathan Moggs, Richard S Paules, François Pognan, Frank Staedtler, Martin P Vidgeon-Hart, Olivier Grenet, Philippe Couttet
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40395 (2012)
Anti-cancer therapy based on anthracyclines (DNA intercalating Topoisomerase II inhibitors) is limited by adverse effects of these compounds on the cardiovascular system, ultimately causing heart failure. Despite extensive investigations into the eff
Externí odkaz:
https://doaj.org/article/1bf1e6df5257478dabeac3b061a4a4f0
Publikováno v:
Journal of Medicinal Chemistry. 37:3503-3510
In furtherance of our SAR study on the chemistry and antitumor activity of fused nitrogen heteroaromatic compounds, a series of linear, methyl-substituted derivatives of 5H- and 6H-indolo[2,3-b]quinolines were synthesized according to the modified Gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fec4b7c478e0129b8a5025a5f314d3c
https://doi.org/10.1021/jm00047a008
https://doi.org/10.1021/jm00047a008
Autor:
Lukasz Kaczmarek, Marian Mordarski, Jean-Marie Saucier, Peczyńska-Czoch W, François Pognan, Paweł Nantka-Namirski, Claude Paoletti
Publikováno v:
Scopus-Elsevier
The DNA intercalating, ellipticine analog drug, 5,11-dimethyl-5 H -indolo[2,3- b ]quinoline, is able to stabilize in vitro the topoisomerase II-DNA cleavable complex and to induce DNA breaks in BPV I episome in rat fibroblasts. Cytotoxicity studies w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3216c053caf7f83ede941dc6be2df0a
https://doi.org/10.1016/0006-2952(92)90341-f
https://doi.org/10.1016/0006-2952(92)90341-f
Publikováno v:
EXS. 99
Recent advances in technological approaches for mapping and characterizing the epigenome are generating a wealth of new opportunities for exploring the relationship between epigenetic modifications, human disease and the therapeutic potential of phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e217ac7d35337bda4be0c5eafcc89e54
https://pubmed.ncbi.nlm.nih.gov/19157065
https://pubmed.ncbi.nlm.nih.gov/19157065
Autor:
François, Pognan
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 64
Toxicology is the perturbation of metabolism by external factors such as xenobiotics, environmental factors or drugs. As such, toxicology covers a broad range of fields from studies of the whole organism responses to minute biochemical events. Mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc71a75d2fa54ec15109234f1b659f8d
https://pubmed.ncbi.nlm.nih.gov/17195477
https://pubmed.ncbi.nlm.nih.gov/17195477
Autor:
Heiko, Schadt, Zuhal, Dincer, Marianne, Schwald, Audrey, Dietz, David, Ledieu, Andre, Cordier, Maria, Papoutsi, Ursula, Junker Walker, Fiona, Spence, Salah-Dine, Chibout, Armin, Wolf, Francois, Pognan
Publikováno v:
In Toxicology Letters 28 August 2013 221 Supplement:S172-S172