Zobrazeno 1 - 10 of 44 pro vyhledávání: '"François Pochon"'
1
Similar Architectures of Native and Transformed Human α2-Macroglobulin Suggest the Transformation Mechanism
Autor: François Pochon, Jean-Christophe Taveau, Jean N. Lamy, Nicolas Boisset
Publikováno v: Journal of Biological Chemistry. 271:25762-25769
The refined three-dimensional structure of native human alpha2-macroglobulin (alpha2M) has been determined by cryoelectron microscopy and three-dimensional reconstruction. New features corresponding to "sigmoid arches," "basal bodies," and "apical co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b66ee377b3adba4c5bbb29e36063582
https://doi.org/10.1074/jbc.271.42.25762
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3
An Approach to the Intramolecular Localization of the Thiol Ester Bonds in the Internal Cavity of Human α2-Macroglobulin Based on Correspondence Analysis
Autor: Etienne Delain, François Pochon, Jean Lamy, Olivier Lambert, Nicolas Boisset
Publikováno v: Journal of Structural Biology. 112:148-159
The plasma proteinase inhibitor alpha 2-macroglobulin (alpha 2M) can trap small proteins including cytokines. With the four internal thiol ester bonds being involved in the covalent binding of proteinases and other ligands, it was of interest to prec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4206240ee14ec1a2ff6db4b5e199a057
https://doi.org/10.1006/jsbi.1994.1016
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4
Three-dimensional reconstruction of a complex of human α2-macroglobulin with monomaleimido nanogold (Au1.4nm) embedded in ice
Autor: Jean N. Lamy, Pawel A. Penczek, François Pochon, Joachim Frank, Nicolas Boisset, Etienne Delain, Robert A. Grassucci
Publikováno v: Journal of Structural Biology. 109:39-45
Cysteine 949 and glutamine 952 are known to be part of the thiol ester site of each of the four subunits of human alpha 2-macroglobulin (alpha 2M). The hydrolysis of this thiol ester bound to methylamine results in the incorporation of the amine and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baee7d6f4c09535d5fcc92f4327a0c6b
https://doi.org/10.1016/1047-8477(92)90065-i
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6
Architecture of native human alpha 2-macroglobulin studied by cryoelectron microscopy and three-dimensional reconstruction
Autor: Nicolas Boisset, Eric Larquet, Jean Lamy, François Pochon
Publikováno v: Journal of structural biology. 113(1)
The architecture of the native human α 2 -macroglobulin was studied by cryoelectron microscopy and image processing techniques. The lip, padlock, doughnut , and four-petaled flower views of this homotetrameric proteinase inhibitor were observed in t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a662602f4176a5e9714632f208e9b675
https://pubmed.ncbi.nlm.nih.gov/7533510
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7
Three-dimensional architecture of human alpha 2-macroglobulin transformed with methylamine
Autor: François Pochon, Nicolas Boisset, Jean N. Lamy, Pawel A. Penczek, Joachim Frank
Publikováno v: Journal of molecular biology. 232(2)
A frozen-hydrated sample embedded in vitreous ice of human α2-macroglobulin transformed by methylamine was imaged by cryoelectron microscopy and reconstructed in three dimensions. In the reconstruction, the cage-like architecture of this protease in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861ab8c656d95f3a86d47767a1298bc0
https://pubmed.ncbi.nlm.nih.gov/7688427
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8
Electron microscopy of alpha 2-macroglobulin with a thiol ester bound ligand
Autor: Etienne Delain, Martine Barray, François Pochon, Nicolas Boisset, Jean Lamy, Serge Chwetzoff
Publikováno v: Journal of Structural Biology
Journal of Structural Biology, Elsevier, 1992, 108 ((3)), pp.221-6
Journal of Structural Biology, 1992, 108 ((3)), pp.221-6
International audience; In order to covalently bind the hydrolyzed thiol ester groups of the human alpha 2-macroglobulin (alpha 2M) transformed by methylamine, the phospholipase A2 (PLA2), a small enzyme (M(r) = 13,000) from Naja nigricollis snake ve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b1d39405a7203b257ac0f2f2cf75ef
https://hal.archives-ouvertes.fr/hal-00815242
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9
Ultrastructure of alpha 2-macroglobulins
Autor: F. Van Leuven, M. Barray, Etienne Delain, François Pochon
Publikováno v: Electron microscopy reviews. 5(2)
New results concerning the ultrastructure of human alpha 2-macroglobulin (alpha 2M) molecules are presented in connection and comparison with the historical, the current and our own most recent, even unpublished results on the structure and function
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9ad13f829a1cc5951def1f6e0e3228
https://pubmed.ncbi.nlm.nih.gov/1374655
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10
Localization of the proteinases in the human alpha 2-macroglobulin-chymotrypsin complex by image processing of electron micrographs
Autor: Martine Barray, François Pochon, Jean-Christophe Taveau, Etienne Delain, Nicolas Boisset, Jean Lamy
Publikováno v: Journal of structural biology. 106(1)
Human alpha 2-macroglobulin (alpha 2M), a large tetrameric plasma glycoprotein, inhibits a wide spectrum of proteinases by a particular "trapping" mechanism resulting from the proteolysis of peptide bonds at specific "bait" regions. This induces the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0036be0a5731c36d03ac6568f3e6985
https://pubmed.ncbi.nlm.nih.gov/1711880
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