Zobrazeno 1 - 10
of 326
pro vyhledávání: '"François Paquet"'
Autor:
Jie Yan, Lan Wang, Qian-Lu Yang, Qian-Xi Yang, Xinyi He, Yujie Dong, Zhulin Hu, Mathias W. Seeliger, Kangwei Jiao, François Paquet-Durand
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-24 (2024)
Abstract Inherited retinal degenerations (IRDs) are a group of untreatable and commonly blinding diseases characterized by progressive photoreceptor loss. IRD pathology has been linked to an excessive activation of cyclic nucleotide-gated channels (C
Externí odkaz:
https://doaj.org/article/4c15f66cef7844cda50e92bf844ca38e
Autor:
Niraj Patel, Vincent Ouellet, François Paquet-Mercier, Nizar Chetoui, Erik Bélanger, Marie-Eve Paquet, Antoine G. Godin, Pierre Marquet
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionHuman induced pluripotent stem cells (iPSCs), with their ability to generate human neural cells (astrocytes and neurons) from patients, hold great promise for understanding the pathophysiology of major neuropsychiatric diseases such as sc
Externí odkaz:
https://doaj.org/article/d75bcabef3a94510a2a7462309492018
Publikováno v:
PeerJ, Vol 11, p e15659 (2023)
Purpose This research aimed to ascertain the neuroprotective effect of histone deacetylase (HDAC) inhibition on retinal photoreceptors in Pde6brd1 mice, a model of retinitis pigmentosa (RP). Methods Single-cell RNA-sequencing (scRNA-seq) explored HDA
Externí odkaz:
https://doaj.org/article/e344d66aae154fbea36ea7e15481618a
Autor:
Gustav Christensen, Yiyi Chen, Dileep Urimi, Laimdota Zizmare, Christoph Trautwein, Nicolaas Schipper, François Paquet-Durand
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 163, Iss , Pp 114717- (2023)
Despite several promising candidates, there is a paucity of drug treatments available for patients suffering from retinal diseases. An important reason for this is the lack of suitable delivery systems that can achieve sufficiently high drug uptake i
Externí odkaz:
https://doaj.org/article/cb1d4b121fc54ec287cf71c2e440afd5
Autor:
Akanksha Roy, Arianna Tolone, Riet Hilhorst, John Groten, Tushar Tomar, François Paquet-Durand
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Inherited retinal diseases (IRDs) are a group of neurodegenerative disorders that lead to photoreceptor cell death and eventually blindness. IRDs are characterised by a high genetic heterogeneity, making it imperative to design mutation-inde
Externí odkaz:
https://doaj.org/article/78efcf27405940b8a50d8b999e7e43f9
Autor:
Soumyaparna Das, Valerie Popp, Michael Power, Kathrin Groeneveld, Jie Yan, Christian Melle, Luke Rogerson, Marlly Achury, Frank Schwede, Torsten Strasser, Thomas Euler, François Paquet-Durand, Vasilica Nache
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Hereditary degeneration of photoreceptors has been linked to over-activation of Ca2+-permeable channels, excessive Ca2+-influx, and downstream activation of Ca2+-dependent calpain-type proteases. Unfortunately, after more than 20 years of pe
Externí odkaz:
https://doaj.org/article/741ab8d66de74b94808151e4999d3c2b
Publikováno v:
Bioengineering, Vol 10, Iss 6, p 725 (2023)
Background: The electroretinogram (ERG) is an essential diagnostic tool for visual function, both in clinical and research settings. Here, we establish an advanced in vitro approach to assess cell-type-specific ERG signal components. Methods: Retinal
Externí odkaz:
https://doaj.org/article/ceaed8dc600540e283b55e74a325e485
Autor:
Yu Zhu, Bowen Cao, Arianna Tolone, Jie Yan, Gustav Christensen, Blanca Arango-Gonzalez, Marius Ueffing, François Paquet-Durand
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Therapy development for neurodegenerative diseases of the retina constitutes a major unmet medical need, and this may be particularly relevant for inherited diseases of the retina, which are largely untreatable to this day. Therapy development necess
Externí odkaz:
https://doaj.org/article/9e4ecf6b0271404aa2dd8540bbb1e0a1
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 581 (2023)
Inherited retinal degeneration (IRD) represents a diverse group of gene mutation-induced blinding diseases. In IRD, the loss of photoreceptors is often connected to excessive activation of histone-deacetylase (HDAC), poly-ADP-ribose-polymerase (PARP)
Externí odkaz:
https://doaj.org/article/977321f387724f19a4062361dc580977
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Purpose: The present work investigated changes in the gene expression, molecular mechanisms, and pathogenesis of inherited retinal degeneration (RD) in three different disease models, to identify predictive biomarkers for their varied phenotypes and
Externí odkaz:
https://doaj.org/article/f15b1a97f7c84896aa9ad9081765b06e