Výsledky vyhledávání - "François M. Sement"

Akademický článek

The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis

Autor: Hélène Scheer, Caroline de Almeida, Emilie Ferrier, Quentin Simonnot, Laure Poirier, David Pflieger, François M. Sement, Sandrine Koechler, Christina Piermaria, Paweł Krawczyk, Seweryn Mroczek, Johana Chicher, Lauriane Kuhn, Andrzej Dziembowski, Philippe Hammann, Hélène Zuber, Dominique Gagliardi

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

TUTase mediated uridylation of mRNA promotes degradation. Here, Scheer, de Almeida et al. show that Arabidopsis TUTase URT1 interacts directly with the translation inhibitor and decay factor DECAPPING5 and suppresses siRNA biogenesis by preventing ac

Externí odkaz: https://doaj.org/article/d26320e63277491b9c09179e1c48bfd5

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Akademický článek

The RNA helicases AtMTR4 and HEN2 target specific subsets of nuclear transcripts for degradation by the nuclear exosome in Arabidopsis thaliana.

Autor: Heike Lange, Hélène Zuber, François M Sement, Johana Chicher, Lauriane Kuhn, Philippe Hammann, Véronique Brunaud, Caroline Bérard, Nathalie Bouteiller, Sandrine Balzergue, Sébastien Aubourg, Marie-Laure Martin-Magniette, Hervé Vaucheret, Dominique Gagliardi

Publikováno v: PLoS Genetics, Vol 10, Iss 8, p e1004564 (2014)

The RNA exosome is the major 3'-5' RNA degradation machine of eukaryotic cells and participates in processing, surveillance and turnover of both nuclear and cytoplasmic RNA. In both yeast and human, all nuclear functions of the exosome require the RN

Externí odkaz: https://doaj.org/article/710c1e580ee1447b91382568c2b2f192

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The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis

Autor: Emilie Ferrier, Philippe Hammann, Christina Piermaria, Pawel S. Krawczyk, Laure Poirier, Dominique Gagliardi, Hélène Zuber, Quentin Simonnot, François M. Sement, Johana Chicher, Caroline de Almeida, Andrzej Dziembowski, Seweryn Mroczek, Sandrine Koechler, Hélène Scheer, David Pflieger, Lauriane Kuhn

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-21382-2⟩

Uridylation is a widespread modification destabilizing eukaryotic mRNAs. Yet, molecular mechanisms underlying TUTase-mediated mRNA degradation remain mostly unresolved. Here, we report that the Arabidopsis TUTase URT1 participates in a molecular netw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c14c1dbe381aa1986d6ed5ccfc0da5
https://doi.org/10.1038/s41467-021-21382-2

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PPR polyadenylation factor defines mitochondrial mRNA identity and stability in trypanosomes

Autor: Takuma Suematsu, Ruslan Aphasizhev, Liye Zhang, Lan Huang, François M. Sement, Inna Aphasizheva, Stefano Monti, Tian Yu

Publikováno v: The EMBO Journal. 36:2435-2454

In Trypanosoma brucei , most mitochondrial mRNAs undergo internal changes by RNA editing and 3′ end modifications. The temporally separated and functionally distinct modifications are manifested by adenylation prior to editing, and by post‐editin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f7818cf19760127d9c249545c063c6
https://doi.org/10.15252/embj.201796808

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Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei

Autor: François M. Sement, Liye Zhang, Takuma Suematsu, Clinton Yu, Tian Yu, Mikhail V. Mesitov, Lan Huang, Inna Aphasizheva

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature communications, vol 10, iss 1

In Trypanosoma brucei, most mitochondrial mRNAs undergo editing, and 3′ adenylation and uridylation. The internal sequence changes and terminal extensions are coordinated: pre-editing addition of the short (A) tail protects the edited transcript ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02be183fc424c452d621ce25bd9d71e
http://europepmc.org/articles/PMC6329795

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The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness

Autor: Leonhard Heizinger, Eva Grauer, Rainer Merkl, Erdmute Kunstmann, Rajyalakshmi Meduri, Daniele Hasler, Utz Fischer, Reinhard Kalb, François M. Sement, Mo-Fang Liu, Gerhard Lehmann, Astrid Bruckmann, Gunter Meister, Zhi-Tong Li, Xin Wang, Mihaela Zavolan, Anne-Catherine Dock-Bregeon, Maciej Bąk

Publikováno v: Molecular Cell. 77:1014-1031.e13

The La-related protein 7 (LARP7) forms a complex with the nuclear 7SK RNA to regulate RNA polymerase II transcription. It has been implicated in cancer and the Alazami syndrome, a severe developmental disorder. Here, we report a so far unknown role o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e168287ef814173fd10486ed65352cf
https://doi.org/10.1016/j.molcel.2020.01.001

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Pentatricopeptide repeat poly(A) binding protein from mitochondria of trypanosomes

Autor: Liye Zhang, François M. Sement, Takuma Suematsu, Inna Afasizheva, Clinton Yu, Tian Yu, Mikhail V. Mesitov, Lan Huang

In Trypanosoma brucei, most mitochondrial mRNAs undergo U-insertion/deletion editing, and 3′ adenylation and uridylation. The internal sequence changes and terminal extensions are coordinated: Pre-editing addition of the short (A) tail protects the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108ae8e158a89d8f9a94e0554e26c484

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Transcription initiation defines kinetoplast RNA boundaries

Autor: Takuma Suematsu, Ruslan Aphasizhev, Inna Aphasizheva, François M. Sement, Tian Yu, Liye Zhang, Lan Huang

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 44

Mitochondrial genomes are often transcribed into polycistronic primary RNAs punctuated by tRNAs whose excision defines mature RNA boundaries. Although kinetoplast DNA lacks tRNA genes, it is commonly held that monophosphorylated 5′-ends of function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc31b622e2390937fbaf3c69eea7f7e5
https://doi.org/10.1101/350256

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Distinct 18S rRNA precursors are targets of the exosome complex, the exoribonuclease RRP6L2 and the terminal nucleotidyltransferase TRL inArabidopsis thaliana

Autor: Hélène Zuber, Pawel J. Sikorski, Heike Lange, Joanna Kufel, Lucas Philippe, Dominique Gagliardi, Jean Canaday, François M. Sement

Publikováno v: The Plant Journal. 83:991-1004

The biosynthesis of ribosomal RNA and its incorporation into functional ribosomes is an essential and intricate process that includes production of mature ribosomal RNA from large precursors. Here, we analyse the contribution of the plant exosome and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bcda41de8d8c41f346c30a114a8a6b
https://doi.org/10.1111/tpj.12943

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Uridylation and PABP cooperate to repair mRNA deadenylated ends in Arabidopsis

Autor: Dominique Gagliardi, Benjamin Stupfler, Pierre Mercier, Hélène Zuber, Hélène Scheer, François M. Sement, Emilie Ferrier

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2016, 14 (11), pp.2707-2717. ⟨10.1016/j.celrep.2016.02.060⟩
Cell Reports, Vol 14, Iss 11, Pp 2707-2717 (2016)

Summary Uridylation emerges as a key modification promoting mRNA degradation in eukaryotes. In addition, uridylation by URT1 prevents the accumulation of excessively deadenylated mRNAs in Arabidopsis . Here, we show that the extent of mRNA deadenylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc408a48a87d3ddce658220a6e19d3b
https://hal.archives-ouvertes.fr/hal-02185924/file/islandora_79692.pdf

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