Zobrazeno 1 - 10
of 102
pro vyhledávání: '"François Lévesque"'
Autor:
Holly E. Bonfield, Thomas Knauber, François Lévesque, Eric G. Moschetta, Flavien Susanne, Lee J. Edwards
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-4 (2020)
A pharmaceutical industry viewpoint on how the fundamental laws of photochemistry are used to identify the parameters required to implement photochemistry from lab to scale. Parameters such as photon stoichiometry and light intensity are highlighted
Externí odkaz:
https://doaj.org/article/c9016fc44960416fa1ceca7a8c7a3ae8
Publikováno v:
Robotics, Vol 8, Iss 3, p 79 (2019)
Grasping an unknown object in a pile is no easy task for a robot—it is often difficult to distinguish different objects; objects occlude one another; object proximity limits the number of feasible grasps available; and so forth. In this paper, we p
Externí odkaz:
https://doaj.org/article/14ab5488cb0e4ed78151962d4b033f88
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 7, Iss 1, Pp 1124-1129 (2011)
Photolysis of aryl azides to give nitrenes, and their subsequent rearrangement in the presence of water to give 3H-azepinones, is performed in continuous flow in a photoreactor constructed of fluorinated ethylene polymer (FEP) tubing. Fine tuning of
Externí odkaz:
https://doaj.org/article/1788428547c64be4a920ed02667fa770
Autor:
Cecilia Bottecchia, Dan Lehnherr, François Lévesque, Mikhail Reibarkh, Yining Ji, Vailankanni L. Rodrigues, Heather Wang, Yu-hong Lam, Thomas P. Vickery, Brittany M. Armstrong, Keith A. Mattern, Kevin Stone, Michael K. Wismer, Andrew N. Singh, Erik L. Regalado, Kevin M. Maloney, Neil A. Strotman
Publikováno v:
Organic Process Research & Development. 26:2423-2437
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fd2896dadfc04cb7d667bdf24213166
https://doi.org/10.1021/acs.oprd.2c00111
https://doi.org/10.1021/acs.oprd.2c00111
Autor:
Glenn Spencer, Michael K. Wismer, Karthik Narsimhan, Lushi Tan, Cecilia Bottecchia, Jonathan P. McMullen, Yining Ji, Dan Lehnherr, Mikhail Reibarkh, Stephen M. Dalby, Like Chen, Feng Peng, Yipeng Lin, François Lévesque, Jarod Nappi
Publikováno v:
Organic Process Research & Development. 26:516-524
We report the development and scale-up of a continuous flow photochemical benzylic bromination en route to belzutifan (MK-6482), a small molecule for the treatment of renal cell carcinoma associate...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::638402ae7c0a8cfd84d7d73f59f1d748
https://doi.org/10.1021/acs.oprd.1c00240
https://doi.org/10.1021/acs.oprd.1c00240
Autor:
Dan Lehnherr, Jonathan P. McMullen, François Lévesque, Stephen M. Dalby, Yining Ji, Karthik Narsimhan, Kai-Jiong Xiao, Mikhail Reibarkh, Cecilia Bottecchia
Publikováno v:
The Journal of Organic Chemistry. 87:2055-2062
A detailed mechanistic understanding of a benzylic photobromination en route to belzutifan (MK-6482, a small molecule for the treatment of renal cell carcinoma associated with von Hippel-Lindau syndrome) has been achieved using in situ LED-NMR spectr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149b43f1c7b397633b5e05c4aeee12a1
https://doi.org/10.1021/acs.joc.1c01465
https://doi.org/10.1021/acs.joc.1c01465
Publikováno v:
Organic Process Research & Development. 24:2935-2940
A simple and inexpensive photoreactor with a throughput of kilograms of material per day has been developed. This achievement was enabled by using high-power Light Emitting Diodes (LEDs) to provide...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dedadb6c415b213d3b5eddca4e95638c
https://doi.org/10.1021/acs.oprd.0c00373
https://doi.org/10.1021/acs.oprd.0c00373
Autor:
Eric B. Sirota, Karthik Narsimhan, Feng Peng, Mark Weisel, Alfred Y. Lee, Rebecca A. Arvary, Claire Lee, Daniel Bishara, Kevin M. Maloney, Andrew Brunskill, François Lévesque, Patrick Larpent, Michael Whittington, John R. Naber, Guy R. Humphrey, Dan Lehnherr, Si-Wei Zhang
Publikováno v:
Organic Process Research & Development. 24:2453-2461
Various synthetic routes to 2-isopropyl-4-methoxyphenol 3, the phenol core of Gefapixant citrate (MK-7264), are described, which provide better alternatives to the initial four-step supply route. T...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d1151aa0b8950e409e75134288d2f80
https://doi.org/10.1021/acs.oprd.0c00241
https://doi.org/10.1021/acs.oprd.0c00241
Autor:
Zhixun Wang, Eric B. Sirota, Mark Weisel, John Y. L. Chung, Aaron M. Whittaker, Cyndi Qixin He, Donald R. Gauthier, François Lévesque, Danielle M. Schultz, Akasha K. Purohit, Yong-Li Zhong, Yingju Xu, Jonathan P. McMullen, Guy R. Humphrey, Varsolona Richard J, Cynthia M. Hong, Kevin M. Maloney
Publikováno v:
Organic Process Research & Development. 25:395-404
We report the practical synthesis of a key fragment of islatravir (MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor (NRTTI) currently under investigation for treatment and...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbb878695b7066d10e2d7723b11cd71a
https://doi.org/10.1021/acs.oprd.0c00304
https://doi.org/10.1021/acs.oprd.0c00304
Publikováno v:
Angewandte Chemie. 132:12062-12066
With the development of new photocatalytic methods over recent decades, the translation of these chemical reactions to industrial-production scales using continuous-flow reactors has become a topic of increasing interest. In this context, we describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c883da2cb6392d1cb52d0727855e81
https://doi.org/10.1002/ange.201915412
https://doi.org/10.1002/ange.201915412