Zobrazeno 1 - 8
of 8
pro vyhledávání: '"François Gaudet"'
Autor:
François Gaudet, Daniel Wall, Hong Lei, Wendy L. Marston, Julia K. Kurash, En Li, Qiong Shen, Brian Granda, Hong Fan
Publikováno v:
Molecular Cell. 29(3):392-400
The protein methyltransferase Set7/9 was recently shown to regulate p53 activity in cancer cells. However, the impact of Set7/9 on p53 function in vivo is unclear. To explore these issues, we created a null allele of Set7/9 in mice. Cells from Set7/9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0b73cae2ef49c74b7cc424b5b8322e
Autor:
Jessica Dausman, Alexander Meissner, William M. Rideout, Heinrich Leonhardt, Rudolph Jaenisch, François Gaudet
Publikováno v:
Molecular and Cellular Biology. 24:1640-1648
The methylation of intracisternal A-type particle (IAP) sequences is maintained during mouse embryogenesis. Methylation suppresses IAP expression and the potential for mutagenesis by retrotransposition, but it is not clear how methylation of these el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55635f8398991c337b77cfdc5bffdc70
https://doi.org/10.1128/mcb.24.4.1640-1648.2004
https://doi.org/10.1128/mcb.24.4.1640-1648.2004
Autor:
Jessica Dausman, Joe W. Gray, Rudolf Jaenisch, François Gaudet, J. Graeme Hodgson, Laurie Jackson-Grusby, Amir Eden, Heinrich Leonhardt
Publikováno v:
Science. 300:489-492
Genome-wide DNA hypomethylation occurs in many human cancers, but whether this epigenetic change is a cause or consequence of tumorigenesis has been unclear. To explore this phenomenon, we generated mice carrying a hypomorphic DNA methyltransferase 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e661a261a3825814d8c28b2db58bbd9
https://doi.org/10.1126/science.1083558
https://doi.org/10.1126/science.1083558
Autor:
Jing Wang, Sarah Hevi, Julia K Kurash, Hong Lei, Frédérique Gay, Jeffrey Bajko, Hui Su, Weitao Sun, Hua Chang, Guoliang Xu, François Gaudet, En Li, Taiping Chen
Publikováno v:
Nature genetics. 41(1)
Histone methylation and DNA methylation cooperatively regulate chromatin structure and gene activity. How these two systems coordinate with each other remains unclear. Here we study the biological function of lysine-specific demethylase 1 (LSD1, also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c28b464c1a036ef06f3773b1f3a8eed
https://pubmed.ncbi.nlm.nih.gov/19112458
https://pubmed.ncbi.nlm.nih.gov/19112458
Autor:
Joost Gribnau, Jörn Walter, David Humpherys, Mary-Ann Mastrangelo, Detlev Biniszkiewicz, Zhan Jun, Bernard Ramsahoye, François Gaudet, Rudolf Jaenisch, Kevin Eggan
Publikováno v:
Molecular and cellular biology. 22(7)
Biallelic expression of Igf2 is frequently seen in cancers because Igf2 functions as a survival factor. In many tumors the activation of Igf2 expression has been correlated with de novo methylation of the imprinted region. We have compared the intrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a53b0a2f42613f92621ac7cf8583fc
https://pubmed.ncbi.nlm.nih.gov/11884600
https://pubmed.ncbi.nlm.nih.gov/11884600
Publikováno v:
Science. 302:1153-1153
We have recently shown that genome-wide DNA hypomethylation induces genomic instability and tumors in animals ([ 1 ][1], [ 2 ][2]). Based on these results, we cautioned that long-term treatment with a demethylating agent such as 5-aza-2′deoxycytidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69cb355d95f377b19a50f965c5ce5143
https://doi.org/10.1126/science.1089838
https://doi.org/10.1126/science.1089838
Publikováno v:
Science. 300:455-455
Human tumors often display changes in DNA methylation, including both genome-wide hypomethylation and site-specific hypermethylation ( [1][1], [2][2] ). In mice, DNA hypomethylation is sufficient to induce T cell lymphomas with consistent gain of chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3ed581aad435907956f9b3b7dd5ab6
https://doi.org/10.1126/science.1083557
https://doi.org/10.1126/science.1083557
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 7, Pp 1284-1293 (1999)
Cholesteryl ester transfer protein (CETP) is expressed in human adipocytes, where it acts to promote selective uptake of HDL-CE (Benoist, F., M. McDonnell, P. Lau, R. Milne, and R. McPherson. 1997. J. Biol. Chem. 272: 23572–23577). In contrast to o
Externí odkaz:
https://doaj.org/article/edee5541353c4fa7b7c705a26c7466a9