Mathematical modeling of the microtubule detyrosination/tyrosination cycle for cell-based drug screening design.

Autor: Jeremy Grignard, Véronique Lamamy, Eva Vermersch, Philippe Delagrange, Jean-Philippe Stephan, Thierry Dorval, François Fages

Publikováno v: PLoS Computational Biology, Vol 18, Iss 6, p e1010236 (2022)

Microtubules and their post-translational modifications are involved in major cellular processes. In severe diseases such as neurodegenerative disorders, tyrosinated tubulin and tyrosinated microtubules are in lower concentration. We present here a m

Externí odkaz: https://doaj.org/article/3d16e595403746aaa89094b4c56820f4

Competing G protein‐coupled receptor kinases balance G protein and β‐arrestin signaling

Autor: Domitille Heitzler, Guillaume Durand, Nathalie Gallay, Aurélien Rizk, Seungkirl Ahn, Jihee Kim, Jonathan D Violin, Laurence Dupuy, Christophe Gauthier, Vincent Piketty, Pascale Crépieux, Anne Poupon, Frédérique Clément, François Fages, Robert J Lefkowitz, Eric Reiter

Publikováno v: Molecular Systems Biology, Vol 8, Iss 1, Pp 1-17 (2012)

Abstract Seven‐transmembrane receptors (7TMRs) are involved in nearly all aspects of chemical communications and represent major drug targets. 7TMRs transmit their signals not only via heterotrimeric G proteins but also through β‐arrestins, whos

Externí odkaz: https://doaj.org/article/36341ec006974a4487849a5c5291ac17

Computational modelling predicts impaired barrier function and higher sensitivity to skin inflammation following pH elevation

Autor: Eléa Thibault Greugny, Jalil Bensaci, François Fages, Georgios N. Stamatas

Publikováno v: Experimental Dermatology
Experimental Dermatology, 2022, ⟨10.1111/exd.14698⟩

Skin surface pH has been identified as a key regulator of the epidermal homeostasis through its action on serine protease activity. These enzymes, like kallikreins (KLK), are responsible for the degradation of corneodesmosomes, the protein structures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a725d5ef6fbafb51536f37337757911
https://inria.hal.science/hal-03909897

Biomachines for Medical Diagnosis

Autor: Asma Bahri, Franck Molina, Julie Baptiste, Julien Espeut, Mellis Alali, Patrick Amar, Francisco Santos Schneider, François Fages

Publikováno v: Advanced Materials Letters
Advanced Materials Letters, VBRI Press, 2020, 11 (4), pp.1-5. ⟨10.5185/amlett.2020.041499⟩
Advanced Materials Letters, 2020, 11 (4), pp.1-5. ⟨10.5185/amlett.2020.041499⟩

International audience; Current evolutions in medical practices induce a change of paradigm with the convergence of diagnosis and therapy, going to precision medicine and “theranostics”. One can observe the new role of biomarkers in biomedical an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d85df7f985a7434cb403f20db3e94b
https://doi.org/10.5185/amlett.2020.041499

Graphical Conditions for Rate Independence in Chemical Reaction Networks

Autor: Sylvain Soliman, Elisabeth Degrand, François Fages

Publikováno v: Proceedings CMSB 2020: The 18th International Conference on Computational Methods in Systems Biology
CMSB 2020-18th International Conference on Computational Methods in Systems Biology
CMSB 2020-18th International Conference on Computational Methods in Systems Biology, Sep 2020, Konstanz / Online, Germany
Computational Methods in Systems Biology ISBN: 9783030603267
CMSB
HAL

Chemical Reaction Networks (CRNs) provide a useful abstraction of molecular interaction networks in which molecular structures as well as mass conservation principles are abstracted away to focus on the main dynamical properties of the network struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c8a45fba05f66b21ec32873682603b
https://inria.hal.science/hal-02900758/document