Výsledky vyhledávání - "François Eliaers"

Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence

Autor: Peter Mose Larsen, Stephen J. Fey, José Remacle, Olivier Toussaint, Jean-François Dierick, Martine Raes, François Eliaers

Publikováno v: Dierick, J F, Eliaers, F, Remacle, J, Raes, M, Fey, S J, Mose Larsen, P & Toussaint, O 2002, ' Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence ', Biochemical Pharmacology, vol. 64, pp. 1011-1017 .

In this paper, we illustrate how a proteomic analysis can be useful to approach complex biological problems, in this case the concept of stress-induced premature senescence (SIPS). According to the stochastic theories of ageing, damage that accumulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7f3b722daf589e143d3f943d9cbe23
https://doi.org/10.1016/s0006-2952(02)01171-1

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Identification of the phospholipase A2 isoforms that contribute to arachidonic acid release in hypoxic endothelial cells: limits of phospholipase A2 inhibitors

Autor: Rozenn Quarck, François Eliaers, Martine Raes, N Bouaziz, Paul Holvoet, Patricia Renard, Carine Michiels, Noelle Ninane, Nathalie Heck

Publikováno v: Biochemical Pharmacology. 63:321-332

Changes in endothelium functions during ischemia are thought to be of importance in numerous pathological conditions, with, for instance, an increase in the release of inflammatory mediators like prostaglandins. Here, we showed that hypoxia increases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989d17c582dcdc9bb07327cdfc921d34
https://doi.org/10.1016/s0006-2952(01)00832-2

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Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence

Autor: Véronique Royer, Olivier Toussaint, João Pedro de Magalhães, Thierry Pascal, Jean-François Dierick, José Remacle, Christophe Frippiat, Florence Chainiaux, François Eliaers, Patrick Dumont

Publikováno v: FEBS Letters. 502:109-112

WI-38 human diploid fibroblasts underwent accelerated telomere shortening (490 bp/stress) and growth arrest after exposure to four subcytotoxic 100 microM tert-butylhydroperoxide (t-BHP) stresses, with a stress at every two population doublings (PD).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e601da2689fab58d895ad185e60691
https://doi.org/10.1016/s0014-5793(01)02679-5

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Effect of venotropic drugs on the respiratory activity of isolated mitochondria and in endothelial cells

Autor: Edouard Delaive, Andrée Houbion, Carine Michiels, José Remacle, Dominique Janssens, François Eliaers

Publikováno v: British Journal of Pharmacology. 130:1513-1524

Several drugs used in the treatment of chronic peripheral ischaemic and venous diseases, i.e. aescine, Cyclo 3, Ginkor Fort, hydroxyethylrutosides, naftidrofuryl, naphthoquinone and procyanidolic oligomers, were tested on the mitochondrial respirator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cbaa27bdba4fffff47d9c5e30416203
https://doi.org/10.1038/sj.bjp.0703461

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[Untitled]

Autor: Olivier Toussaint, Patrick Dumont, Florence Chainiaux, José Remacle, Thierry Pascal, Jean François Dierick, François Eliaers, João Pedro de Magalhães, Christophe Frippiat

Publikováno v: Biogerontology. 1:179-183

No alternative in vitro method exists fordetecting the potential long-term genotoxic effects ofmolecules at subcytotoxic concentrations, in terms ofdays and weeks after exposure(s) to the moleculetested. A theoretical model of cellular senescence led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::696a1934eed1fef64a62d6179823512c
https://doi.org/10.1023/a:1010035712199

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Development of a Serum Free Meditum for a Human Diploid Fibroblast Cell Line

Autor: Sabine Pirotton, Dominique Delforge, Janique Dewelle, François Eliaers, Martine Raes

Publikováno v: Animal Cell Technology: Products from Cells, Cells as Products ISBN: 9780792360759

The aim of this work was to formulate a serum-free medium (or a medium containing a reduced serum concentration) for MRC-5 cells (human diploid fibroblasts from foetal lung. The screening was performed in multi-well plates using the propidium iodide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38def904a3dda328212d4944fcebe14f
https://doi.org/10.1007/0-306-46875-1_44

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Protection of hypoxia-induced ATP decrease in endothelial cells by ginkgo biloba extract and bilobalide

Autor: Dominique Janssens, Carine Michiels, Edouard Delaive, François Eliaers, Katy Drieu, José Remacle

Publikováno v: Biochemical pharmacology. 50(7)

Due to their localization at the interface between blood and tissue, endothelial cells are the first target of any change occurring within the blood, and alterations of their functions can seriously impair organs. During hypoxia, which mimics in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8addeabbfeb31999e4da48674c51ce90
https://pubmed.ncbi.nlm.nih.gov/7575684

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