Zobrazeno 1 - 10
of 12
pro vyhledávání: '"François Delfaud"'
Autor:
Laetitia Chanas-Martin, François Delfaud, Stewart A. Adcock, Marouane Ben Jelloul, Stéphane Richard, Fabrice Moriaud, Jean-Sébastien Surgand
Publikováno v:
Briefings in Bioinformatics. 12:336-340
Predicting off-targets by computational methods is gaining increasing interest in early-stage drug discovery. Here, we present a computational method based on full 3D comparisons of 3D structures. When a similar binding site is detected in the Protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abcc1aea43ae28ad0a88b7d007e0f483
https://doi.org/10.1093/bib/bbr017
https://doi.org/10.1093/bib/bbr017
Publikováno v:
Protein Science
Protein Science, Wiley, 2010, 19 (4), pp.847-67. ⟨10.1002/pro.364⟩
Protein Science, Wiley, 2010, 19 (4), pp.847-67. ⟨10.1002/pro.364⟩
International audience; Ligand-protein interactions are essential for biological processes, and precise characterization of protein binding sites is crucial to understand protein functions. MED-SuMo is a powerful technology to localize similar local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fd9715a33225ea5823beb206cddc79
https://doi.org/10.1002/pro.364
https://doi.org/10.1002/pro.364
Publikováno v:
Current Protein & Peptide Science. 7:369-393
The processes used by academic and industrial scientists to discover new drugs have recently experienced a true renaissance with many new and exciting techniques. The number of protein structures and/or chemical ligands is con- stantly growing, throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c25d5181b54e920df1df8bd64617bd9
https://doi.org/10.2174/138920306778559377
https://doi.org/10.2174/138920306778559377
Publikováno v:
Protein science : a publication of the Protein Society. 19(4)
Ligand–protein interactions are essential for biological processes, and precise characterization of protein binding sites is crucial to understand protein functions. MED-SuMo is a powerful technology to localize similar local regions on protein sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ac9cd30b1bf1f76d55c4cca3bf9efaff
https://pubmed.ncbi.nlm.nih.gov/20162627
https://pubmed.ncbi.nlm.nih.gov/20162627
Publikováno v:
Infectious disorders drug targets. 9(3)
Resolved three-dimensional protein structures are a major source of information for understanding protein functional properties. The current explosive growth of publicly available protein structures is producing large volumes of data for computationa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4f01782cb843b1c4c87d19de3863dc
https://pubmed.ncbi.nlm.nih.gov/19519487
https://pubmed.ncbi.nlm.nih.gov/19519487
Autor:
Fabrice Moriaud, Ksenia Oguievetskaia, Artem Vorotyntsev, Stewart A. Adcock, Laetitia Martin, Olivia Doppelt-Azeroual, François Delfaud, Kerstin Koch
Publikováno v:
Journal of chemical information and modeling. 49(2)
The large volume of protein-ligand structures now available enables innovative and efficient protocols in computational FBDD (Fragment-Based Drug Design) to be proposed based on experimental data. In this work, we build a database of MED-Portions, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85cd8c93f2126be04f2b7e574187722f
https://pubmed.ncbi.nlm.nih.gov/19434830
https://pubmed.ncbi.nlm.nih.gov/19434830
Autor:
François Delfaud, Stewart A. Adcock, Fabrice Moriaud, Olivia Doppelt-Azeroual, Artem Vorotyntsev, Laetitia Martin-Chanas, Alexandre G. de Brevern, Xavier Brotel, Ksenia Oguievetskaia
Publikováno v:
Journal of Computer-Aided Molecular Design
Journal of Computer-Aided Molecular Design, Springer Verlag, 2009, 23 (8), pp.571-82. ⟨10.1007/s10822-009-9286-z⟩
Journal of Cheminformatics
Journal of Cheminformatics, Vol 2, Iss Suppl 1, p P29 (2010)
Journal of Computer-Aided Molecular Design, Springer Verlag, 2009, 23 (8), pp.571-82. ⟨10.1007/s10822-009-9286-z⟩
Journal of Cheminformatics
Journal of Cheminformatics, Vol 2, Iss Suppl 1, p P29 (2010)
International audience; Eg5, a mitotic kinesin exclusively involved in the formation and function of the mitotic spindle has attracted interest as an anticancer drug target. Eg5 is co-crystallized with several inhibitors bound to its allosteric bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ebf68f4cb9e2acb406ae080341c0d0
https://pubmed.ncbi.nlm.nih.gov/19533373
https://pubmed.ncbi.nlm.nih.gov/19533373
Autor:
Christophe Combet, François Delfaud, Martin Jambon, Olivier Andrieu, Christophe Geourjon, Gilbert Deléage
Publikováno v:
Bioinformatics
Bioinformatics, Oxford University Press (OUP), 2005, 21 (20), pp.3929-30. ⟨10.1093/bioinformatics/bti645⟩
Bioinformatics, Oxford University Press (OUP), 2005, 21 (20), pp.3929-30. ⟨10.1093/bioinformatics/bti645⟩
International audience; SUMMARY: We provide the scientific community with a web server which gives access to SuMo, a bioinformatic system for finding similarities in arbitrary 3D structures or substructures of proteins. SuMo is based on a unique repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b463d16cac4f877256cfbccc1ad151c9
https://hal.archives-ouvertes.fr/hal-00313736
https://hal.archives-ouvertes.fr/hal-00313736
Autor:
Olivier Sperandio, Olivier Andrieu, Maria A. Miteva, Minh-Quang Vo, Marc Souaille, François Delfaud, Bruno O. Villoutreix
Publikováno v:
Journal of Chemical Information & Modeling; May2007, Vol. 47 Issue 3, p1097-1110, 14p
Autor:
François Delfaud, Fabrice Moriaud, L Martin, AG De Brevern, Stewart A. Adcock, AM Vorotynsev, O Doppelt, T Henry
Publikováno v:
Chemistry Central Journal
Fragment- based drug design has emerged in the last decade. This exciting field has been recently reviewed [1]. Obtaining structural information on the fragment complexed to the protein target is a key factor and also a major limitation. Therefore, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa797bdc33b4c3e66fd2ae2078cf0524