Zobrazeno 1 - 10
of 58
pro vyhledávání: '"François Bachand"'
Autor:
Carlo Yague-Sanz, Valérie Migeot, Marc Larochelle, François Bachand, Maxime Wéry, Antonin Morillon, Damien Hermand
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The packaging of the genetic material into chromatin imposes the remodeling of this barrier to allow efficient transcription. RNA polymerase II activity is coupled with several histone modification complexes that enforce remodeling. How RNA
Externí odkaz:
https://doaj.org/article/1904125f91314cff8954778fd696b1ca
Autor:
Maxime Duval, Carlo Yague-Sanz, Tomasz W. Turowski, Elisabeth Petfalski, David Tollervey, François Bachand
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Transcription by RNA polymerase I (RNAPI) represents most of the transcriptional activity in eukaryotic cells and is associated with the production of mature ribosomal RNA (rRNA). As several rRNA maturation steps are coupled to RNAPI transcr
Externí odkaz:
https://doaj.org/article/319fde815ac84a9cb9fc2cc527d6bb29
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 853 (2023)
Ribosomal proteins are fundamental components of the ribosomes in all living cells. The ribosomal protein uS5 (Rps2) is a stable component of the small ribosomal subunit within all three domains of life. In addition to its interactions with proximal
Externí odkaz:
https://doaj.org/article/10ea7aa1e855426cbe07e8df4059630a
Autor:
Marc Larochelle, Marc-Antoine Robert, Jean-Nicolas Hébert, Xiaochuan Liu, Dominick Matteau, Sébastien Rodrigue, Bin Tian, Pierre-Étienne Jacques, François Bachand
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Termination of RNA polymerase II (RNAPII) transcription is an essential step of gene expression. Here the authors provide evidence that in fission yeast termination of ncRNA genes occurs by a cleavage-dependent mechanism involving recruitment of mRNA
Externí odkaz:
https://doaj.org/article/1de494ea30714a22bec8e626430ecc54
Autor:
Duy Nguyen, Valérie Grenier St-Sauveur, Danny Bergeron, Fabien Dupuis-Sandoval, Michelle S. Scott, François Bachand
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2244-2257 (2015)
Telomere maintenance by the telomerase reverse transcriptase requires a noncoding RNA subunit that acts as a template for the synthesis of telomeric repeats. In humans, the telomerase RNA (hTR) is a non-polyadenylated transcript produced from an inde
Externí odkaz:
https://doaj.org/article/a673fb434fc645e68c120f180ab9da02
Autor:
Yves B Beaulieu, Claudia L Kleinman, Anne-Marie Landry-Voyer, Jacek Majewski, François Bachand
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003078 (2012)
The poly(A)-binding protein nuclear 1 (PABPN1) is a ubiquitously expressed protein that is thought to function during mRNA poly(A) tail synthesis in the nucleus. Despite the predicted role of PABPN1 in mRNA polyadenylation, little is known about the
Externí odkaz:
https://doaj.org/article/711d93ef041e468184fbe13d13fc0545
Autor:
Eric Massé, François Bachand, Darren Henry, Vincent Normant, Simon Labbé, Gordon Chua, Jude Beaudoin, Ariane Brault
Publikováno v:
Molecular Microbiology. 116:1361-1377
This study identifies a post-transcriptional mechanism of iron uptake regulation by Puf2 and Puf4 of the Pumilio and FBF (Puf) family of RNA-binding proteins in Schizosaccharomyces pombe. Cells expressing Puf2 and Puf4 stimulate decay of the frp1+ mR
Publikováno v:
Nucleic Acids Research
PDCD2 is an evolutionarily conserved protein with previously characterized homologs in Drosophila (zfrp8) and budding yeast (Tsr4). Although mammalian PDCD2 is essential for cell proliferation and embryonic development, the function of PDCD2 that und
Autor:
Simon Labbé, Carlo Yague-Sanz, Maxime Duval, Marc Larochelle, Jude Beaudoin, Ronan Fernandez, Yann Vanrobaeys, Julien Berro, François Bachand, Pierre-Étienne Jacques
Publikováno v:
Genes Dev
Transcription by RNA polymerase II (RNAPII) is a dynamic process with frequent variations in the elongation rate. However, the physiological relevance of variations in RNAPII elongation kinetics has remained unclear. Here we show in yeast that a RNAP
Publikováno v:
Nucleic Acids Research
Transcription termination of protein-coding genes in eukaryotic cells usually relies on a tight coordination between the cleavage and polyadenylation of the pre-mRNA, and 5′-3′ degradation of the downstream nascent transcript. Here we investigate