Zobrazeno 1 - 10
of 44
pro vyhledávání: '"François‐Ludovic Sauvage"'
Autor:
Rudy Mevizou, Hassan Aouad, François-Ludovic Sauvage, Hélène Arnion, Emilie Pinault, Jean-Sébastien Bernard, Gildas Bertho, Nicolas Giraud, Rodolphe Alves de Sousa, Adolfo Lopez-Noriega, Florent Di Meo, Mélanie Campana, Pierre Marquet
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107438- (2024)
The toxicity of tacrolimus metabolites and their potential pharmacodynamic (PD) interactions with tacrolimus might respectively explain the surprising combination of higher toxicity and lower efficacy of tacrolimus despite normal blood concentrations
Externí odkaz:
https://doaj.org/article/7cced53101f24641acb5f420f0f7c47b
Autor:
Hassan Aouad, Quentin Faucher, François-Ludovic Sauvage, Emilie Pinault, Claire-Cécile Barrot, Hélène Arnion, Marie Essig, Pierre Marquet
Publikováno v:
Pharmacological Research, Vol 192, Iss , Pp 106794- (2023)
Introduction: Tacrolimus, an immunosuppressive drug prescribed to a majority of organ transplant recipients is nephrotoxic, through still unclear mechanisms. This study on a lineage of proximal tubular cells using a multi-omics approach aims to detec
Externí odkaz:
https://doaj.org/article/45dbed16cfd6460f8970db1828359190
Autor:
Manon Jardou, Quentin Provost, Clarisse Brossier, Émilie Pinault, François-Ludovic Sauvage, Roland Lawson
Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background Mycophenolic acid (MPA) is the most widely used immunosuppressive drug in transplantation and for autoimmune diseases. Unfortunately, more than 30% of patients experience a typical gastrointestinal adverse effect also referred to
Externí odkaz:
https://doaj.org/article/682b8246e981442887cc1be41bb57519
Autor:
Bastien Burat, Quentin Faucher, Petra Čechová, Hélène Arnion, Florent Di Meo, François‐Ludovic Sauvage, Pierre Marquet, Marie Essig
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 9, Pp 561-578 (2019)
Abstract Calcineurin inhibitors (CNI) are the pillars of immunosuppression in transplantation. However, they display a potent nephrotoxicity whose mechanisms remained widely unsolved. We used an untargeted quantitative proteomic approach (iTRAQ techn
Externí odkaz:
https://doaj.org/article/5e8946918e97447cbb33ca516da59200
Autor:
Ziad A. Massy, François-Ludovic Sauvage, Gabriel Choukroun, Marie Essig, Souleiman El Balkhi, Aurélie Lenglet, Mohamad Ali Rahali, Sophie Liabeuf
Publikováno v:
Drugs in R&D
Drugs in R&D, Springer Verlag, 2021, 21 (2), pp.231-238. ⟨10.1007/s40268-021-00350-7⟩
Drugs in R&D, 2021, 21 (2), pp.231-238. ⟨10.1007/s40268-021-00350-7⟩
Drugs in R&D, Springer Verlag, 2021, 21 (2), pp.231-238. ⟨10.1007/s40268-021-00350-7⟩
Drugs in R&D, 2021, 21 (2), pp.231-238. ⟨10.1007/s40268-021-00350-7⟩
Background and Objective In end-stage kidney disease, high urea levels promote the carbamylation of lysine side chains on a variety of proteins, including albumin. Albumin carbamylation has been identified as a risk factor for mortality and sevelamer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44dbd707c6775e23ab843dce5a4de42e
https://doi.org/10.1007/s40268-021-00350-7
https://doi.org/10.1007/s40268-021-00350-7
Autor:
Joseph Berthier, Nicolas Picard, François-Ludovic Sauvage, Pierre Marquet, Benjamin Chantemargue, Hélène Arnion, Gabin Fabre, Franck Saint-Marcoux, Mehdi Benmameri, Patrick Trouillas
Publikováno v:
Xenobiotica. 51:105-114
Mycophenolic acid (MPA) has become a cornerstone of immunosuppressive therapy, in particular for transplant patients. In the gastrointestinal tract, the liver and the kidney, MPA is mainly metabolized into phenyl-β-d glucuronide (MPAG). Knowledge ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad854d066575c7d75375dc3eea9deab3
https://doi.org/10.1080/00498254.2020.1813352
https://doi.org/10.1080/00498254.2020.1813352
Autor:
Roland Lawson, Quentin Provost, François-Ludovic Sauvage, Clarisse Brossier, Émilie Pinault, Manon Jardou
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-9 (2021)
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-9 (2021)
Background Mycophenolic acid (MPA) is the most widely used immunosuppressive drug in transplantation and for autoimmune diseases. Unfortunately, more than 30% of patients experience a typical gastrointestinal adverse effect also referred to as mycoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df24204ffdd910a68911eabadcf3b4f6
https://doi.org/10.1186/s40360-021-00536-4
https://doi.org/10.1186/s40360-021-00536-4
Autor:
Pierre Marquet, Franck Bruyère, Nicolas Brichart, Hugo Alarcan, François-Ludovic Sauvage, Lydie Nadal-Desbarats, Chantal Barin-Le Guellec, Quentin Faucher, Elodie Miquelestorena-Standley, Jean-Christophe Venhard, Lionel Forestier, Hélène Arnion
BackgroundIschemia-related injury during the pre-implantation period impacts kidney graft outcome. Evaluating these lesions by a non-invasive approach before transplantation could help to understand the mechanisms of graft injury and identify potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ca4925a35980667b93397129157e381
https://doi.org/10.1101/2021.09.27.21264167
https://doi.org/10.1101/2021.09.27.21264167
Autor:
Emilie Pinault, Marie Essig, Hélène Arnion, Pierre Marquet, Quentin Faucher, François-Ludovic Sauvage, Hassan Aouad, Claire-Cécile Barrot
Tacrolimus, prescribed to a majority of transplanted patients is associated with nephrotoxicity, the mechanism of which remains unclear. This study aims to evaluate the impact of tacrolimus on proximal tubular cells using a multi-omics approach. LLC-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f067f929ee4fdefd46d2a2e253e17a4d
https://doi.org/10.1101/2021.07.29.454229
https://doi.org/10.1101/2021.07.29.454229