Zobrazeno 1 - 10
of 733
pro vyhledávání: '"François, Pattou"'
Autor:
Laurent L’homme, Benan Pelin Sermikli, Joel T. Haas, Sébastien Fleury, Sandrine Quemener, Valentine Guinot, Emelie Barreby, Nathalie Esser, Robert Caiazzo, Hélène Verkindt, Benjamin Legendre, Violeta Raverdy, Lydie Cheval, Nicolas Paquot, Jacques Piette, Sylvie Legrand-Poels, Myriam Aouadi, François Pattou, Bart Staels, David Dombrowicz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Plasma growth differentiation factor-15 (GDF-15) levels increase with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) but the underlying mechanism remains poorly defined. Using male mouse models of obesity and MA
Externí odkaz:
https://doaj.org/article/0165911603514238b8604a2d501f0ef0
Autor:
Fabian Wirth, Fabrice D. Heitz, Christine Seeger, Ioana Combaluzier, Karin Breu, Heather C. Denroche, Julien Thevenet, Melania Osto, Paolo Arosio, Julie Kerr-Conte, C. Bruce Verchere, François Pattou, Thomas A. Lutz, Marc Y. Donath, Christoph Hock, Roger M. Nitsch, Jan Grimm
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose. Beta cell dysfunction and loss is associated with an accumulation of aggregated
Externí odkaz:
https://doaj.org/article/68eb80d31bdf42208e648a12724a93bf
Autor:
Pierre Bauvin, Claire Delacôte, Line Carolle Ntandja Wandji, Guillaume Lassailly, Violeta Raverdy, François Pattou, Sylvie Deuffic-Burban, Philippe Mathurin
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0301463 (2024)
ObjectiveHelp public health decision-making requires a better understanding of the dynamics of obesity and type 2 diabetes and an assessement of different strategies to decrease their burdens.MethodsBased on 97,848 individual data, collected in the F
Externí odkaz:
https://doaj.org/article/b298df07b1c949239e723401a1fbd46d
Autor:
Manuel Johanns, Joel T. Haas, Violetta Raverdy, Jimmy Vandel, Julie Chevalier-Dubois, Loic Guille, Bruno Derudas, Benjamin Legendre, Robert Caiazzo, Helene Verkindt, Viviane Gnemmi, Emmanuelle Leteurtre, Mehdi Derhourhi, Amélie Bonnefond, Philippe Froguel, Jérôme Eeckhoute, Guillaume Lassailly, Philippe Mathurin, François Pattou, Bart Staels, Philippe Lefebvre
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100948- (2024)
Background & Aims: Liver homeostasis is ensured in part by time-of-day-dependent processes, many of them being paced by the molecular circadian clock. Liver functions are compromised in metabolic dysfunction-associated steatotic liver disease (MASLD)
Externí odkaz:
https://doaj.org/article/4fd9fffee41d4c35be393a757aed20a5
Autor:
Mikael Chetboun, Christophe Masset, Mehdi Maanaoui, Frédérique Defrance, Valéry Gmyr, Violeta Raverdy, Thomas Hubert, Caroline Bonner, Lisa Supiot, Clarisse Kerleau, Gilles Blancho, Julien Branchereau, Georges Karam, Ismaël Chelghaf, Aurélie Houzet, Magali Giral, Claire Garandeau, Jacques Dantal, Kristell Le Mapihan, Arnaud Jannin, Marc Hazzan, Robert Caiazzo, Julie Kerr-Conte, Marie-Christine Vantyghem, Diego Cantarovich, François Pattou
Publikováno v:
Transplant International, Vol 36 (2023)
In islet transplantation (ITx), primary graft function (PGF) or beta cell function measured early after last infusion is closely associated with long term clinical outcomes. We investigated the association between PGF and 5 year insulin independence
Externí odkaz:
https://doaj.org/article/de1ea47d87a44a57b986f55e27ec6ea1
Autor:
Patrick Saux, MSc, Pierre Bauvin, PhD, Violeta Raverdy, MD, Julien Teigny, BEng, Hélène Verkindt, MD, Tomy Soumphonphakdy, MSc, Maxence Debert, MSc, Anne Jacobs, MSc, Daan Jacobs, BSc, Valerie Monpellier, PhD, Phong Ching Lee, MBChB, Chin Hong Lim, FRCS, Johanna C Andersson-Assarsson, PhD, Lena Carlsson, ProfMD, Per-Arne Svensson, ProfPhD, Florence Galtier, MD, Guelareh Dezfoulian, MD, Mihaela Moldovanu, MD, Severine Andrieux, MD, Julien Couster, MD, Marie Lepage, MD, Erminia Lembo, MD, Ornella Verrastro, PhD, Maud Robert, ProfMD PhD, Paulina Salminen, ProfMD PhD, Geltrude Mingrone, ProfMD PhD, Ralph Peterli, MD, Ricardo V Cohen, MD PhD, Carlos Zerrweck, ProfMD, David Nocca, ProfMD PhD, Carel W Le Roux, ProfMD PhD, Robert Caiazzo, ProfMD PhD, Philippe Preux, ProfPhD, François Pattou, ProfMD PhD
Publikováno v:
The Lancet: Digital Health, Vol 5, Iss 10, Pp e692-e702 (2023)
Summary: Background: Weight loss trajectories after bariatric surgery vary widely between individuals, and predicting weight loss before the operation remains challenging. We aimed to develop a model using machine learning to provide individual preop
Externí odkaz:
https://doaj.org/article/522ce7af6bbe4160a6c5a5d23bac7256
Autor:
Marie Bobowski-Gerard, Clémence Boulet, Francesco P. Zummo, Julie Dubois-Chevalier, Céline Gheeraert, Mohamed Bou Saleh, Jean-Marc Strub, Amaury Farce, Maheul Ploton, Loïc Guille, Jimmy Vandel, Antonino Bongiovanni, Ninon Very, Eloïse Woitrain, Audrey Deprince, Fanny Lalloyer, Eric Bauge, Lise Ferri, Line-Carolle Ntandja-Wandji, Alexia K. Cotte, Corinne Grangette, Emmanuelle Vallez, Sarah Cianférani, Violeta Raverdy, Robert Caiazzo, Viviane Gnemmi, Emmanuelle Leteurtre, Benoit Pourcet, Réjane Paumelle, Kim Ravnskjaer, Guillaume Lassailly, Joel T. Haas, Philippe Mathurin, François Pattou, Laurent Dubuquoy, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Myofibroblasts contribute to the development of liver fibrosis. Here, the authors report that the transcription factor Basonuclin 2 (BNC2) integrates fibrogenic signals and drives myofibroblastic transcriptional activation in liver fibrosis.
Externí odkaz:
https://doaj.org/article/c0d2d56ec91641b79809fad780054395
Autor:
Frédérik Oger, Maeva Moreno, Mehdi Derhourhi, Bryan Thiroux, Lionel Berberian, Cyril Bourouh, Emmanuelle Durand, Souhila Amanzougarene, Alaa Badreddine, Etienne Blanc, Olivier Molendi-Coste, Laurent Pineau, Gianni Pasquetti, Laure Rolland, Charlène Carney, Florine Bornaque, Emilie Courty, Céline Gheeraert, Jérôme Eeckhoute, David Dombrowicz, Julie Kerr-Conte, François Pattou, Bart Staels, Philippe Froguel, Amélie Bonnefond, Jean-Sébastien Annicotte
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107231- (2023)
Summary: Histone deacetylases enzymes (HDACs) are chromatin modifiers that regulate gene expression through deacetylation of lysine residues within specific histone and non-histone proteins. A cell-specific gene expression pattern defines the identit
Externí odkaz:
https://doaj.org/article/75620a5d73cf44908a7169d2d5030f87
Autor:
Rébecca Goutchtat, Audrey Quenon, Manon Clarisse, Nathalie Delalleau, Anaïs Coddeville, Mathilde Gobert, Valéry Gmyr, Julie Kerr‐Conte, François Pattou, Thomas Hubert
Publikováno v:
Endocrinology, Diabetes & Metabolism, Vol 6, Iss 4, Pp n/a-n/a (2023)
Abstract Introduction Nowadays, there are no strong diabetic pig models, yet they are required for various types of diabetes research. Using cutting‐edge techniques, we attempted to develop a type 2 diabetic minipig model in this study by combining
Externí odkaz:
https://doaj.org/article/6c47b3bb4b4d49faa4f6f4f60ff4da2e
Autor:
Aurélie Mailliez, MD, Camille Ternynck, PhD, Arnaud Jannin, MD, Madleen Lemaître, MD, Benjamin Chevalier, MD, Kristell Le Mapihan, MD, Frédérique Defrance, MD, Marie-Anne Mackowiak, MD, Adeline Rollin, MD, Maanaoui Mehdi, MD, Mikael Chetboun, MD, François Pattou, MD, PhD, Florence Pasquier, MD, PhD, Marie-Christine Vantyghem, MD, PhD
Publikováno v:
Transplantation Direct, Vol 9, Iss 6, p e1493 (2023)
Background. Severe or repeated hypoglycemia events may favor memory complaints in type 1 diabetes (T1D). Pancreatic islet transplantation (IT) is an alternative option to exogenous insulin therapy in case of labile T1D, implying a maintenance immunos
Externí odkaz:
https://doaj.org/article/4d33f87ba5554cbaa9e10c40ea9a6c4f