A plant-derived morphinan as a novel lead compound active against malaria liver stages.

Autor: Maëlle Carraz, Akino Jossang, Jean-François Franetich, Anthony Siau, Liliane Ciceron, Laurent Hannoun, Robert Sauerwein, François Frappier, Philippe Rasoanaivo, Georges Snounou, Dominique Mazier

Publikováno v: PLoS Medicine, Vol 3, Iss 12, p e513 (2006)

BACKGROUND: The global spread of multidrug-resistant malaria parasites has led to an urgent need for new chemotherapeutic agents. Drug discovery is primarily directed to the asexual blood stages, and few drugs that are effective against the obligator

Externí odkaz: https://doaj.org/article/ed7760a79dcf439382c884cde7661ac5

Synthesis and antimalarial evaluation of a series of piperazinyl flavones

Autor: Gwenola Auffret, Guy Lewin, François Frappier, Philippe Rasoanaivo, Philippe Grellier, Mehdi Labaied

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2007, 17 (4), pp.959-963. ⟨10.1016/j.bmcl.2006.11.051⟩

A series of 27 flavonoid derivatives containing a piperazinyl chain have been synthesized and tested for their antiplasmodial activity. Diverse substitution patterns on piperazinyl and flavone moieties were examined and found to affect the activity d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37cb25ffaaed573a54a516f31b50962b
https://doi.org/10.1016/j.bmcl.2006.11.051

Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline

Autor: Philippe Rasoanaivoa, Van Cuong Pham, François Frappier, Jean Jacques Youte, Roger Joyeau, François Trigalo

Publikováno v: Tetrahedron
Tetrahedron, Elsevier, 2004, 60 (25), pp.5471-5474. ⟨10.1016/j.tet.2004.04.068⟩

The syntheses of three malagashanine analogues are reported. They involve conversion of strychnobrasiline in multiple steps and obtaining (i) unsaturation of the bond 3-14, (ii) inversion of configuration on carbon C3, (iii) inversion of configuratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c95e5339f8146d11c3c545a28ca39d
https://doi.org/10.1016/j.tet.2004.04.068

Cytotoxicity and DNA binding properties of the plant alkaloid burasaine

Autor: Brigitte Baldeyrou, Pierre Colson, Jerome Kluza, Lengo Mambu, Christian Bailly, François Frappier, Philippe Rasoanaivo

Publikováno v: European Journal of Pharmaceutical Sciences. 20:383-391

Burasaine is a plant alkaloid isolated from the roots of several species of the Burasaia genus endemic to Madagascar. It exhibits in vitro antiplasmodial activities but the molecular basis of this biological activity is not known. The strong structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94537d40e7aa6f130e2459b0da262cab
https://doi.org/10.1016/j.ejps.2003.08.007

Minor Nb,C(21)-secocuran alkaloids of Strychnos myrtoides

Autor: Philippe Rasoanaivo, Marie-Thérèse Martin, François Trigalo, Corrado Galeffi, Giovanna Palazzino, Marcello Nicoletti, François Frappier

Publikováno v: Phytochemistry. 51:479-486

From the stem bark of Strychnos myrtoides in addition to strychnobrasiline and malagashanine, four minor alkaloids, viz. malagashanol, 12-hydroxy-19-epi-malagashanine, myrtoidine and 11-demethoxymyrtoidine were isolated and their structures were esta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ae3441a6d525f92182d85f0fc7e90d2
https://doi.org/10.1016/s0031-9422(99)00033-3