Zobrazeno 1 - 10
of 10
pro vyhledávání: '"François, Chevallier"'
Autor:
Hortense Deronzier, Cecile Dorleans, John Waller, Laurent Saniere, Andre Fouquet, Fiona Elizabeth Andrews, Mark Baugh, J.C.M. Uitdehaag, George McGarry, Phil Jones, Ann Mitchell, Emma Kinghorn, Eric Nicolai, Wilson Caulfield, Zoran Rankovic, Dominique Potin, Mario van Zeeland, Wullie Arbuckle, Jennifer Kerr, Jiaqiang Cai, Mark Wheaton Anderson, Iain Martin, Maureen Dempster, Ashvin Mistry, François Chevallier, William Finlay, Clive Long, Robinson John E, Xavier Fradera, Paul Westwood, Iain Cumming
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6237-6241
Several structure-guided optimisation strategies were explored in order to improve the hERG selectivity profile of cathepsin K inhibitor 1 , whilst maintaining its otherwise excellent in vitro and in vivo profile. Ultimately, attenuation of c log P a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbcfb747e700da9944dc50d293047fcc
https://doi.org/10.1016/j.bmcl.2010.08.101
https://doi.org/10.1016/j.bmcl.2010.08.101
Autor:
Eric Nicolai, Clive Long, Ann Mitchell, Maureen Dempster, William Hamilton, Jennifer Kerr, Cecile Dorleans, Iain Martin, Paul Scullion, Hortense Deronzier, John Bruin, Emma Hamilton, Zoran Rankovic, Andre Fouquet, John Robinson, John Waller, Laurent Saniere, Mark Baugh, Fiona Andrews, Jiaqiang Cai, Joost C.M. Uitdehaag, Wilson Caulfield, Dominique Potin, Ashvin Mistry, François Chevallier, Paul Westwood, Emma Kinghorn, George McGarry, Iain Cumming, Mario van Zeeland, X. Fradera
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1524-1527
Morphing structural features of HTS-derived chemotypes led to the discovery of novel 2-cyano-pyrimidine inhibitors of cathepsin K with good pharmacokinetic profiles, for example, compound 20 showed high catK potency (IC(50)=4nM), >580-fold selectivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3024221a3f1580ea5f971d2c310f2b7
https://doi.org/10.1016/j.bmcl.2010.01.100
https://doi.org/10.1016/j.bmcl.2010.01.100
Autor:
Iain Cumming, Andre Fouquet, Hortense Deronzier, Mark Baugh, William Finlay, Emma Kinghorn, Zoran Rankovic, Jiaqiang Cai, Eric Nicolai, Maureen Dempster, Mario van Zeeland, François Chevallier, Jennifer Kerr, Sylviane Boucharens, George McGarry, William Hamilton, Xavier Fradera, J.C.M. Uitdehaag, Robinson John E, Laurent Saniere, Dominique Potin, Jonathan Gillespie, John Bruin, Paul Scullion, D. Jonathan Bennett, Cecile Dorleans, Kenneth S. Cameron
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(15)
Starting from previously disclosed equally potent cathepsin K and S inhibitor 4-propyl-6-(3-trifluoromethylphenyl)pyrimidine-2-carbonitrile 1, a novel 2-phenyl-9H-purine-6-carbonitrile scaffold was identified to provide potent and selective cathepsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98bd55a43ebd81843ae171f54be9d64
https://pubmed.ncbi.nlm.nih.gov/20594841
https://pubmed.ncbi.nlm.nih.gov/20594841
Autor:
Dominique, Potin, Michele, Launay, Francoise, Monatlik, Patrice, Malabre, Maud, Fabreguettes, Andre, Fouquet, Magali, Maillet, Eric, Nicolai, Loïc, Dorgeret, François, Chevallier, Dominique, Besse, Monique, Dufort, François, Caussade, Syed Z, Ahmad, Dawn K, Stetsko, Stacey, Skala, Patricia M, Davis, Praveen, Balimane, Karishma, Patel, Zheng, Yang, Punit, Marathe, Jennifer, Postelneck, Robert M, Townsend, Valentina, Goldfarb, Steven, Sheriff, Howard, Einspahr, Kevin, Kish, Mary F, Malley, John D, DiMarco, Jack Z, Gougoutas, Pathanjali, Kadiyala, Daniel L, Cheney, Ravindra W, Tejwani, Denette K, Murphy, Kim W, Mcintyre, Xiaoxia, Yang, Sam, Chao, Leslie, Leith, Zili, Xiao, Arvind, Mathur, Bang-Chi, Chen, Daugh-Rurng, Wu, Sarah C, Traeger, Murray, McKinnon, Joel C, Barrish, Jeffrey A, Robl, Edwin J, Iwanowicz, Suzanne J, Suchard, T G Murali, Dhar
Publikováno v:
Journal of medicinal chemistry. 49(24)
LFA-1 (leukocyte function-associated antigen-1), is a member of the beta2-integrin family and is expressed on all leukocytes. This letter describes the discovery and preliminary SAR of spirocyclic hydantoin based LFA-1 antagonists that culminated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::678c8cc3816580fa1740622533be39a5
https://pubmed.ncbi.nlm.nih.gov/17125246
https://pubmed.ncbi.nlm.nih.gov/17125246
Publikováno v:
Journal of Solid State Electrochemistry; Oct2006, Vol. 10 Issue 10, p857-864, 8p
Publikováno v:
Journal of Biological Chemistry. 233:305-310
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d2f741b997f7c3eae293d2fb51d975a
https://doi.org/10.1016/s0021-9258(18)64755-6
https://doi.org/10.1016/s0021-9258(18)64755-6
Publikováno v:
The Journal of Experimental Medicine
Rats were fed, for 3 days, four synthetic diets, all of which contained the same proportion of carbohydrate (50 per cent) and were of equal caloric value per gram. These diets contained either 0 or 15 per cent fat. The fats used were lard, corn oil,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea9db18404ff68b5bb86e528bee7726
https://doi.org/10.1084/jem.107.6.813
https://doi.org/10.1084/jem.107.6.813
Publikováno v:
Revue économique. 36:1301
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1457c29f8a9add13758cceb53daebe
https://doi.org/10.2307/3501670
https://doi.org/10.2307/3501670
Autor:
Extra, Charly
Publikováno v:
Sciences du Vivant [q-bio]. 2021
Introduction : les exploitants agricoles indépendants français sont soumis à un risque plus élevé d’accident du travail et de maladie professionnelle, à un risque plus élevé de suicide, et bien que leur espérance de vie soit peu ou prou si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::de8449dda650c2b5041d0abe3909d17c
https://dumas.ccsd.cnrs.fr/dumas-03208537/document
https://dumas.ccsd.cnrs.fr/dumas-03208537/document
Autor:
Bonnet, Pierre-André
Publikováno v:
Médecine humaine et pathologie. Université de la Méditerranée-Aix-Marseille II, 2009. Français
Bibliotherapy means to use a written document to treat or prevent a mental disease. It is unknown in France wherever it could be usefull specialy un primary care. Objective: - Knowledge about biblotherapy and its use in primary care - Understand how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::60539fefbfe81b2a4d495847d7ccbf72
https://theses.hal.science/tel-00641546
https://theses.hal.science/tel-00641546