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The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates

Autor: Buhigas, Claudia, Warren, Anne Y., Leung, Wing-Kit, Whitaker, Hayley C., Luxton, Hayley J., Hawkins, Steve, Kay, Jonathan, Butler, Adam, Xu, Yaobo, Woodcock, Dan J., Merson, Sue, Frame, Fiona M., Sahli, Atef, Abascal, Federico, Gihawi, Abraham, Lambert, Adam, Thompson, Alan, Futreal, Andrew, Menzies, Andrew, Baddage, Anne, Ng, Anthony, Sahil, Atef, Kremeyer, Barbara, Al-Lazikani, Bissan, Massie, Charlie, Greenman, Christopher, Ogden, Christopher, Verrill, Clare, Fisher, Cyril, Berney, Dan, Burns, Dan, Leongamornlert, Daniel, Jones, David, Nicol, David, Wedge, David C., Cahill, Declan, Easton, Douglas, Rowe, Edward, Riabchenko, Ekaterina, Bancroft, Elizabeth, Mayer, Erik, Anokian, Ezequiel, Hamdy, Freddie, Park, Gahee, Pelvender, Gill, Leeman, Gregory, Gundem, Gunes, Zhang, Hongwei, Mills, Ian G., Zhang, Jingjing, Teague, Jon, Zamora, Jorge, Karaszi, Katalin, Raine, Kieran, Matthews, Lucy, Stebbings, Lucy, Alexandrov, Ludmil B., Marsden, Luke, Ahmed, Mahbubl, Nykter, Matti, Ghori, Mohammed, Livni, Naomi, Dennis, Nening, Van As, Nicholas, Camacho, Niedzica, Shah, Nimish, Kumar, Pardeep, Van Loo, Peter, Lach, Radoslaw, Edwards, Sandra, Pita, Sara, Field, Sarah J., Thomas, Sarah, Tavaré, Simon, Scalabrino, Stefania, Hazell, Steven, McLaren, Stuart, Visakorpi, Tapio, Mitchell, Thomas J., Dudderidge, Tim, Dadaev, Tokhir, McDermott, Ultan, Bo, Valeria, Haberland, Valeriia, Gnanapragasam, Vincent, Khoo, Vincent, Howat, William, Jie-Lu, Yong, Yu, Yongwei, Kote-Jarai, Zsofia, Martincorena, Iñigo, Bova, G. Steven, Foster, Christopher S., Campbell, Peter, Maitland, Norman J., Neal, David E., Massie, Charlie E., Lynch, Andy G., Eeles, Rosalind A., Cooper, Colin S., Brewer, Daniel S., Group, CRUK-ICGC Prostate Cancer

Publikováno v: Buhigas, C, Warren, A Y, Leung, W-K, Whitaker, H C, Luxton, H J, Hawkins, S, Kay, J, Butler, A, Xu, Y, Woodcock, D J, Merson, S, Frame, F M, Sahli, A, Abascal, F, Gihawi, A, Lambert, A, Thompson, A, Futreal, A, Menzies, A, Baddage, A, Ng, A, Sahil, A, Kremeyer, B, Al-Lazikani, B, Massie, C, Greenman, C, Ogden, C, Verrill, C, Fisher, C, Berney, D, Burns, D, Leongamornlert, D, Jones, D, Nicol, D, Wedge, D C, Cahill, D, Easton, D, Rowe, E, Riabchenko, E, Bancroft, E, Mayer, E, Anokian, E, Hamdy, F, Park, G, Pelvender, G, Leeman, G, Gundem, G, Zhang, H, Mills, I G, Zhang, J, Teague, J, Zamora, J, Karaszi, K, Raine, K, Matthews, L, Stebbings, L, Alexandrov, L B, Marsden, L, Ahmed, M, Nykter, M, Ghori, M, Livni, N, Dennis, N, Van As, N, Camacho, N, Shah, N, Kumar, P, Van Loo, P, Lach, R, Edwards, S, Pita, S, Field, S J, Thomas, S, Tavaré, S, Scalabrino, S, Hazell, S, McLaren, S, Visakorpi, T, Mitchell, T J, Dudderidge, T, Dadaev, T, McDermott, U, Bo, V, Haberland, V, Gnanapragasam, V, Khoo, V, Howat, W, Jie-Lu, Y, Yu, Y, Kote-Jarai, Z, Martincorena, I, Bova, G S, Foster, C S, Campbell, P, Maitland, N J, Neal, D E, Massie, C E, Lynch, A G, Eeles, R A, Cooper, C S, Wedge, D C, Brewer, D S & Group, CRUK-ICGC P C 2022, ' The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates ', Molecular Cancer, vol. 21, 183 . https://doi.org/10.1186/s12943-022-01644-3

Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the present study we applied Whole Geno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f94a242c27a0e34917b1939068fbacf
https://doi.org/10.1186/s12943-022-01644-3

Additional file 2 of The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates

Autor: Buhigas, Claudia, Warren, Anne Y., Leung, Wing-Kit, Whitaker, Hayley C., Luxton, Hayley J., Hawkins, Steve, Kay, Jonathan, Butler, Adam, Xu, Yaobo, Woodcock, Dan J., Merson, Sue, Frame, Fiona M., Sahli, Atef, Abascal, Federico, Martincorena, Iñigo, Bova, G. Steven, Foster, Christopher S., Campbell, Peter, Maitland, Norman J., Neal, David E., Massie, Charlie E., Lynch, Andy G., Eeles, Rosalind A., Cooper, Colin S., Wedge, David C., Brewer, Daniel S.

Additional file 2: Supplementary Figure 1. Age vs number of SNVs detected for normal tissue from Prostate cancer patients and non-prostate cancer donors. For the non-cancer donors, the number of SNVs detected is remarkably consistent (range: 104 to 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6b26aa8979649c9f5c4d759e9555bb

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Assessing the Advantages, Limitations and Potential of Human Primary Prostate Epithelial Cells as a Pre-clinical Model for Prostate Cancer Research

Autor: Frame, Fiona M, Noble, Amanda R, O'Toole, Peter, Marrison, Jo, Godden, Timothy, O'Brien, Andrew, Maitland, Norman J

Choosing an appropriate cell model(s) is the first decision to be made before starting a new project or programme of study. Here, we address the rationale that can be behind this decision and we summarize the current cell models that are used to stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::db07dab698a5dab93a713877a553f08a
https://eprints.whiterose.ac.uk/152627/1/Assessing_the_Advantages.pdf