Glia of C. elegans coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit.

Autor: Gildea HK; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Frankino PA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Tronnes SU; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Pender CL; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Durieux J; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Dishart JG; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Choi HO; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Hunter TD; Department of Biology, Howard University, Washington, DC, USA., Cheung SS; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Frakes AE; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Sukarto E; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Wickham K; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Dillin A; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.

Publikováno v: Science advances [Sci Adv] 2022 Dec 09; Vol. 8 (49), pp. eabq3970. Date of Electronic Publication: 2022 Dec 09.

ER Unfolded Protein Response in Liver In Vivo Is Characterized by Reduced, Not Increased, De Novo Lipogenesis and Cholesterol Synthesis Rates with Uptake of Fatty Acids from Adipose Tissue: Integrated Gene Expression, Translation Rates and Metabolic Fluxes.

Autor: Ward CP; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 92093, USA., Peng L; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 92093, USA., Yuen S; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 92093, USA., Chang M; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 92093, USA., Karapetyan R; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 92093, USA., Nyangau E; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 92093, USA., Mohammed H; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 92093, USA., Palacios H; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 92093, USA., Ziari N; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 92093, USA., Joe LK; Department of Molecular and Cellular Biology, University of California, Berkeley, CA 92093, USA., Frakes AE; Department of Molecular and Cellular Biology, University of California, Berkeley, CA 92093, USA., Dandan M; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 92093, USA., Dillin A; Department of Molecular and Cellular Biology, University of California, Berkeley, CA 92093, USA., Hellerstein MK; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 92093, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 19; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 19.

Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans .

Autor: Frakes AE; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA., Metcalf MG; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA., Tronnes SU; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA., Bar-Ziv R; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA., Durieux J; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA., Gildea HK; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA., Kandahari N; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA., Monshietehadi S; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA., Dillin A; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. dillin@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2020 Jan 24; Vol. 367 (6476), pp. 436-440.

Additive amelioration of ALS by co-targeting independent pathogenic mechanisms.

Autor: Frakes AE; Center for Gene Therapy The Research Institute at Nationwide Children's Hospital Columbus Ohio; Biomedical Sciences Graduate Program College of Medicine The Ohio State University Columbus Ohio., Braun L; Center for Gene Therapy The Research Institute at Nationwide Children's Hospital Columbus Ohio., Ferraiuolo L; Center for Gene Therapy The Research Institute at Nationwide Children's Hospital Columbus Ohio., Guttridge DC; Department of Molecular Virology Immunology and Medical Genetics The Ohio State University Columbus Ohio 43210., Kaspar BK; Center for Gene Therapy The Research Institute at Nationwide Children's Hospital Columbus Ohio; Biomedical Sciences Graduate Program College of Medicine The Ohio State University Columbus Ohio.

Publikováno v: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2017 Jan 11; Vol. 4 (2), pp. 76-86. Date of Electronic Publication: 2017 Jan 11 (Print Publication: 2017).

Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.

Autor: Song S; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.; Molecular, Cellular & Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio, USA., Miranda CJ; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA., Braun L; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA., Meyer K; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA., Frakes AE; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio, USA., Ferraiuolo L; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA., Likhite S; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.; Molecular, Cellular & Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio, USA., Bevan AK; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio, USA., Foust KD; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.; Department of Neuroscience, The Ohio State University, Columbus, Ohio, USA., McConnell MJ; Dept. of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA., Walker CM; Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.; Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA., Kaspar BK; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.; Molecular, Cellular & Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio, USA.; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio, USA.; Department of Neuroscience, The Ohio State University, Columbus, Ohio, USA.; Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA.

Publikováno v: Nature medicine [Nat Med] 2016 Apr; Vol. 22 (4), pp. 397-403. Date of Electronic Publication: 2016 Feb 29.