Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Fraidoon Kavoosi"'
Autor:
Masumeh Sanaei, Fraidoon Kavoosi
Publikováno v:
Research in Pharmaceutical Sciences, Vol 17, Iss 4, Pp 392-409 (2022)
Background and purpose: Epigenetics has been defined as the study of mitotically heritable alterations in gene expression that are not caused by changes in DNA sequence. Epigenetic-mediated silencing of a gene includes genomic imprinting, histone dea
Externí odkaz:
https://doaj.org/article/0f337ae209954b779c2aaea45e5e6cfc
Autor:
Masumeh Sanaei, Fraidoon Kavoosi
Publikováno v:
Fiyz̤, Vol 24, Iss 6, Pp 601-609 (2021)
Background: Histone acetylation and deacetylation play an important role in transcription and gene expression. The acetylation status of histones and non-histone proteins is determined by histone acetyl-transferases (HATs) and histone deacetylases (H
Externí odkaz:
https://doaj.org/article/6804b8bbdffd42928de84585154a0c59
Autor:
Masumeh Sanaei, Fraidoon Kavoosi
Publikováno v:
International Journal of Preventive Medicine, Vol 14, Iss 1, Pp 63-63 (2023)
Background: The alteration of DNA cytosine methylation is one of the most common epigenetic changes that can play a significant role in human cancers. The enzymes involved in DNA methylation of promoter regions of the genes are DNA methyltransferases
Externí odkaz:
https://doaj.org/article/e56702a8e3ad4a3280528b33e113af3b
Autor:
Masumeh Sanaei, Fraidoon Kavoosi
Publikováno v:
Research in Pharmaceutical Sciences, Vol 16, Iss 3, Pp 260-268 (2021)
Background and purpose: In mammalian cells, several distinct surveillance systems, named cell cycle checkpoints, can interrupt normal cell-cycle progression. The cyclin-dependent kinases are negatively regulated by proteins of cyclin-dependent kinase
Externí odkaz:
https://doaj.org/article/44f4e667257146b687feee67cce24447
Autor:
Masumeh Sanaei, Fraidoon Kavoosi
Publikováno v:
Asian Pacific Journal of Cancer Biology, Vol 5, Iss 2, Pp 57-62 (2020)
Objective: DNA methylation, the covalent addition of a methyl group to cytosine, and histone modification play an important role in the establishment and maintenance of the program of gene expression. The balance of histone acetylation is determined
Externí odkaz:
https://doaj.org/article/b05281d5e569497f8a83a164919d183f
Publikováno v:
Advanced Biomedical Research, Vol 12, Iss 1, Pp 24-24 (2023)
Background: Epigenetic mechanisms play an important role in the regulation of gene expression and genetic information. DNA methyltransferases are a family of enzymes that methylate DNA at the promoter region of the gene which can significantly contri
Externí odkaz:
https://doaj.org/article/17ba4bd6675e4f549d7c0d91c9d166ed
Publikováno v:
Brazilian Journal of Pharmaceutical Sciences, Vol 57 (2021)
Previously, we evaluated the effect of trichostatin A (TSA) on the expression of DNA methyltransferase 1 (DNMT1) in Hepatocellular Carcinoma (HCC). Fragile histidine triad (FHIT) and WW domain-containing oxidoreductase (WWOX) are two of the most comm
Externí odkaz:
https://doaj.org/article/614c1fae4149418fbbfa1b93457e2374
Autor:
Masumeh Sanaei, Fraidoon Kavoosi
Publikováno v:
Crescent Journal of Medical and Biological Sciences, Vol 6, Iss 4, Pp 441-448 (2019)
Objectives: Histone acetylation is determined by a balance between the activities of the enzymes that are involved in the histone modifications, including histone deacetylases (HDACs) and histone acetyltransferases which affect gene expression and pl
Externí odkaz:
https://doaj.org/article/788b5bf932b94fbc84b66ae6f4b28dbb
Autor:
Masumeh Sanaei, Fraidoon Kavoosi
Publikováno v:
Journal of Advanced Biomedical Sciences, Vol 9, Iss 3, Pp 1534-1541 (2019)
Background & Objective: In the eukaryotic cells, the DNA wraps around the histone proteins (H2A, H2B, H3, and H4) and constitutes the nucleosome. Chromatin organization plays a major role in the control of gene expression. Epigenetic modifications ca
Externí odkaz:
https://doaj.org/article/f2542e0f5bda47c79aabd70b6697c3b1
Publikováno v:
International Journal of Hematology-Oncology and Stem Cell Research, Vol 14, Iss 1 (2020)
Background: Aberrant methylation and histone deacetylation of tumor suppressor genes (TSGs) are the most epigenetic alterations involving in tumorigenesis. Overexpression of DNA methyltransferases (DNMTs) and histone deacetylase 1 (HDAC1) have been r
Externí odkaz:
https://doaj.org/article/8e817f2dd1b9430b8cc36e68f687f4d3