Alpha 1-acid glycoprotein is upregulated in severe COVID-19 patients and decreases neutrophil NETs in SARS-CoV-2 infection.

Autor: Mestriner F; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Francisco DF; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Campos LCB; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Couto AES; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Fraga-Silva TFC; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Sao Paulo, Brazil; Universidade Federal de Alagoas - UFAL, Maceió, AL, Brazil., Flora Dugaich V; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., D Avila-Mesquita C; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Zukowski Kovacs H; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Vasconcelos JL; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Milani ER; Department of Cell and Molecular Biology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Santos Guedes de Sá K; Department of Cell and Molecular Biology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Martins R; Department of Cell and Molecular Biology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Jordani MC; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Corsi CAC; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Barbosa JM; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Vasconcelos T; Division of Intensive Care Medicine, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Gonçalves Menegueti M; Ribeirão Preto Nurse Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Neto J; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Sao Paulo, Brazil., da Costa RM; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Sao Paulo, Brazil., Evora PRB; Division of Thoracic and Cardiovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Arruda E; Department of Cell and Molecular Biology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Tostes R; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Sao Paulo, Brazil., Polonis K; Department of Pathology & Immunology, Division of Laboratory and Genomic Medicine, Washington University in St. Louis, Missouri, USA., Bonato VLD; Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Sao Paulo, Brazil., Auxiliadora-Martins M; Division of Intensive Care Medicine, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Ribeiro MS; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Becari C; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil; Department of Biological Sciences, School of Dentistry of Bauru, University of São Paulo, Bauru, São Paulo, Brazil. Electronic address: cbecari@usp.br.

Publikováno v: Cytokine [Cytokine] 2024 Apr; Vol. 176, pp. 156503. Date of Electronic Publication: 2024 Jan 31.

Naphthoquinone derivatives as potential immunomodulators: prospective for COVID-19 treatment.

Autor: Moraes VT; Departamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo-USP Ribeirão Preto 14040-903 SP Brazil gclososki@usp.br +55 16 3315-4208., Caires FJ; Departamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo-USP Ribeirão Preto 14040-903 SP Brazil gclososki@usp.br +55 16 3315-4208., da Silva-Neto PV; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto-FFCLRP, Universidade de São Paulo-USP Ribeirão Preto 14040-901 SP Brazil., Mendonça JN; Departamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo-USP Ribeirão Preto 14040-903 SP Brazil gclososki@usp.br +55 16 3315-4208., Fraga-Silva TFC; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas-UFAL Maceió 57072-900 AL Brazil.; Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto-FMRP, Universidade de São Paulo-USP Ribeirão Preto 14040-900 SP Brazil., Fontanezi BB; Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo-USP Ribeirão Preto 14040-903 SP Brazil., Marcato PD; Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo-USP Ribeirão Preto 14040-903 SP Brazil., Deperon Bonato VL; Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto-FMRP, Universidade de São Paulo-USP Ribeirão Preto 14040-900 SP Brazil., Sorgi CA; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto-FFCLRP, Universidade de São Paulo-USP Ribeirão Preto 14040-901 SP Brazil., Beraldo Moraes LA; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto-FFCLRP, Universidade de São Paulo-USP Ribeirão Preto 14040-901 SP Brazil., Clososki GC; Departamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo-USP Ribeirão Preto 14040-903 SP Brazil gclososki@usp.br +55 16 3315-4208.

Publikováno v: RSC advances [RSC Adv] 2024 Feb 21; Vol. 14 (10), pp. 6532-6541. Date of Electronic Publication: 2024 Feb 21 (Print Publication: 2024).

Airway epithelial cells and macrophages trigger IL-6-CD95/CD95L axis and mediate initial immunopathology of COVID-19.

Autor: Fraga-Silva TFC; Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Cipriano UG; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Fumagalli MJ; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Correa GF; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Fuzo CA; Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Dos-Santos D; Department of Cell Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Mestriner FLAC; Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Becari C; Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Teixeira-Carvalho A; René Rachou Institute, Oswaldo Cruz Foundation, FIOCRUZ-Minas, Belo Horizonte, Minas Gerais 30190-009, Brazil., Coelho-Dos-Reis J; Department of Microbiology, Biological Science Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil., Menegueti MG; Department of General and Specialized Nursing, Ribeirao Preto Nurse School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Figueiredo LTM; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil.; Virology Research Center, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Cunha LD; Department of Cell Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Martins-Filho OA; René Rachou Institute, Oswaldo Cruz Foundation, FIOCRUZ-Minas, Belo Horizonte, Minas Gerais 30190-009, Brazil., Dias-Baruffi M; Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Auxiliadora-Martins M; Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Tostes RC; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil., Bonato VLD; Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil.; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil.

Publikováno v: IScience [iScience] 2023 Oct 31; Vol. 26 (12), pp. 108366. Date of Electronic Publication: 2023 Oct 31 (Print Publication: 2023).

Plasma Sphingomyelin Disturbances: Unveiling Its Dual Role as a Crucial Immunopathological Factor and a Severity Prognostic Biomarker in COVID-19.

Autor: Toro DM; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.; Postgraduate Program in Basic and Applied Immunology-PPGIBA, Institute of Biological Sciences, Federal University of Amazonas-UFAM, Manaus 69080-900, AM, Brazil., da Silva-Neto PV; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.; Postgraduate Program in Basic and Applied Immunology-PPGIBA, Institute of Biological Sciences, Federal University of Amazonas-UFAM, Manaus 69080-900, AM, Brazil., de Carvalho JCS; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.; Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil., Fuzo CA; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Pérez MM; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Pimentel VE; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Fraga-Silva TFC; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Oliveira CNS; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Caruso GR; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Vilela AFL; Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil., Nobre-Azevedo P; Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil.; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Defelippo-Felippe TV; Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil., Argolo JGM; Department of General and Specialized Nursing, School of Nursing of Ribeirão Preto-EERP, University of São Paulo-USP, Ribeirão Preto 14040-902, SP, Brazil., Degiovani AM; Hospital Santa Casa de Misericórdia de Ribeirão Preto, Ribeirão Preto 14085-000, SP, Brazil., Ostini FM; Hospital Santa Casa de Misericórdia de Ribeirão Preto, Ribeirão Preto 14085-000, SP, Brazil., Feitosa MR; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.; Hospital São Paulo, Ribeirão Preto 14025-100, SP, Brazil., Parra RS; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.; Hospital São Paulo, Ribeirão Preto 14025-100, SP, Brazil., Vilar FC; Hospital São Paulo, Ribeirão Preto 14025-100, SP, Brazil.; Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Gaspar GG; Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Rocha JJRD; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Feres O; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.; Hospital São Paulo, Ribeirão Preto 14025-100, SP, Brazil., Costa GP; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto 14040-900, SP, Brazil., Maruyama SRC; Department of Genetics and Evolution, Center for Biological and Health Sciences, Federal University of São Carlos (UFSCar), São Carlos 13565-905, SP, Brazil., Russo EMS; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Fernandes APM; Department of General and Specialized Nursing, School of Nursing of Ribeirão Preto-EERP, University of São Paulo-USP, Ribeirão Preto 14040-902, SP, Brazil., Santos IKFM; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Malheiro A; Postgraduate Program in Basic and Applied Immunology-PPGIBA, Institute of Biological Sciences, Federal University of Amazonas-UFAM, Manaus 69080-900, AM, Brazil., Sadikot RT; Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA., Bonato VLD; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Cardoso CRB; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Dias-Baruffi M; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Trapé ÁA; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto 14040-900, SP, Brazil., Faccioli LH; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Sorgi CA; Postgraduate Program in Basic and Applied Immunology-PPGIBA, Institute of Biological Sciences, Federal University of Amazonas-UFAM, Manaus 69080-900, AM, Brazil.; Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil.; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., ImmunoCovid Consortium Group

Publikováno v: Cells [Cells] 2023 Jul 26; Vol. 12 (15). Date of Electronic Publication: 2023 Jul 26.

IL-22 Is Deleterious along with IL-17 in Allergic Asthma but Is Not Detrimental in the Comorbidity Asthma and Acute Pneumonia.

Autor: Goulart A; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Sao Paulo, Brazil., Boko MMM; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Sao Paulo, Brazil., Martins NS; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Sao Paulo, Brazil., Gembre AF; Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Sao Paulo, Brazil., de Oliveira RS; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Sao Paulo, Brazil., Palma-Albornoz SP; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Sao Paulo, Brazil., Bertolini T; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Sao Paulo, Brazil., Ribolla PEM; Biotechnology Institute, Sao Paulo State University, Botucatu 18607-440, Sao Paulo, Brazil., Ramalho LNZ; Department of Pathology and Legal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Sao Paulo, Brazil., Fraga-Silva TFC; Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Sao Paulo, Brazil., Bonato VLD; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Sao Paulo, Brazil.; Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Sao Paulo, Brazil.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 21; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 21.