Combination of High-Dose Parenteral Ascorbate (Vitamin C) and Alpha-Lipoic Acid Failed to Enhance Tumor-Inhibitory Effect But Increased Toxicity in Preclinical Cancer Models.

Autor: Chen, Ping¹ (AUTHOR), Lamson, Davis² (AUTHOR), Anderson, Paul³ (AUTHOR), Drisko, Jeanne⁴ (AUTHOR), Chen, Qi¹ (AUTHOR) Qchen@kumc.edu

Publikováno v: Clinical Medicine Insights: Oncology. 10/31/2024, p1-11. 11p.

K V 1.2 channel-specific blocker from Mesobuthus eupeus scorpion venom: Structural basis of selectivity.

Autor: Kuzmenkov AI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia; Biological Faculty, Lomonosov Moscow State University, Moscow, 119992, Russia., Nekrasova OV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia; Biological Faculty, Lomonosov Moscow State University, Moscow, 119992, Russia., Peigneur S; Toxicology and Pharmacology, University of Leuven, Leuven, 3000, Belgium., Tabakmakher VM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia., Gigolaev AM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia; Biological Faculty, Lomonosov Moscow State University, Moscow, 119992, Russia., Fradkov AF; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia; Evrogen JSC, Moscow, 117997, Russia., Kudryashova KS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia; Biological Faculty, Lomonosov Moscow State University, Moscow, 119992, Russia., Chugunov AO; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia; National Research University Higher School of Economics, Moscow, 101000, Russia., Efremov RG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia; National Research University Higher School of Economics, Moscow, 101000, Russia; Moscow Institute of Physics and Technology (State University), Dolgoprudny, 141701, Moscow Oblast, Russia., Tytgat J; Toxicology and Pharmacology, University of Leuven, Leuven, 3000, Belgium., Feofanov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia; Biological Faculty, Lomonosov Moscow State University, Moscow, 119992, Russia., Vassilevski AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia; Moscow Institute of Physics and Technology (State University), Dolgoprudny, 141701, Moscow Oblast, Russia. Electronic address: avas@ibch.ru.

Publikováno v: Neuropharmacology [Neuropharmacology] 2018 Dec; Vol. 143, pp. 228-238. Date of Electronic Publication: 2018 Sep 22.

Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer's disease.

Autor: Calvo-Rodriguez, Maria^1,2 (AUTHOR), Kharitonova, Elizabeth K.¹ (AUTHOR), Snyder, Austin C.¹ (AUTHOR), Hou, Steven S.¹ (AUTHOR), Sanchez-Mico, Maria Virtudes¹ (AUTHOR), Das, Sudeshna¹ (AUTHOR), Fan, Zhanyun¹ (AUTHOR), Shirani, Hamid³ (AUTHOR), Nilsson, K. Peter R.³ (AUTHOR), Serrano-Pozo, Alberto¹ (AUTHOR), Bacskai, Brian J.¹ (AUTHOR) BBACSKAI@mgh.harvard.edu

Publikováno v: Molecular Neurodegeneration. 1/18/2024, Vol. 19 Issue 1, p1-18. 18p.

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