Reduction of oxidative stress suppresses poly-GR-mediated toxicity in zebrafish embryos

Autor: Fréderike W. Riemslagh, Rob F. M. Verhagen, Esmay C. van der Toorn, Daphne J. Smits, Wim H. Quint, Herma C. van der Linde, Tjakko J. van Ham, Rob Willemsen

Publikováno v: Disease Models & Mechanisms, Vol 14, Iss 11 (2021)

The hexanucleotide (G4C2)-repeat expansion in the C9ORF72 gene is the most common pathogenic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). This repeat expansion can be translated into dipeptide repeat proteins (DPRs)

Externí odkaz: https://doaj.org/article/4579136ca9044ab1964e93362e53048d

From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish

Autor: Cassie L. Kemmler, Fréderike W. Riemslagh, Hannah R. Moran, Christian Mosimann

Publikováno v: Journal of Cardiovascular Development and Disease, Vol 8, Iss 2, p 17 (2021)

The heart is the first functional organ to form during vertebrate development. Congenital heart defects are the most common type of human birth defect, many originating as anomalies in early heart development. The zebrafish model provides an accessib

Externí odkaz: https://doaj.org/article/98fc9e6e099f41a983fa0e4fb0e32726

Cover Image

Autor: Robert L. Lalonde, Cassie L. Kemmler, Fréderike W. Riemslagh, Andrew J. Aman, Jelena Kresoja‐Rakic, Hannah R. Moran, Susan Nieuwenhuize, David M. Parichy, Alexa Burger, Christian Mosimann

Publikováno v: Developmental Dynamics. 251

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e12a9d7f50f50aed5b00a391dd375270
https://doi.org/10.1002/dvdy.541

Heterogeneity and genomic loci of ubiquitous Cre reporter transgenes in zebrafish

Autor: Robert L. Lalonde, Cassie L. Kemmler, Fréderike W. Riemslagh, Andrew J. Aman, Jelena Kresoja-Rakic, Hannah R. Moran, Susan Nieuwenhuize, David M. Parichy, Alexa Burger, Christian Mosimann

The most-common strategy for zebrafish Cre/lox-mediated lineage labeling experiments combines ubiquitously expressed, lox-based Switch reporter transgenes with tissue-specific Cre or 4-OH-Tamoxifen-inducible CreERT2 driver lines. Although numerous Cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cea26e0baf384f46f383406dc8efb1f5
https://doi.org/10.1101/2021.12.22.473906

Inducible expression of human C9ORF72 36× G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

Autor: Alex Maas, Rob Willemsen, Fréderike W. Riemslagh, Renate K. Hukema, Rob F M Verhagen, Laurens W. J. Bosman, Esmay C van der Toorn

Publikováno v: Disease Models & Mechanisms
article-version (VoR) Version of Record
DMM Disease Models and Mechanisms, 14(2):dmm044842. Company of Biologists Ltd
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)

The hexanucleotide G4C2 repeat expansion in the first intron of the C9ORF72 gene accounts for the majority of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) cases. Numerous studies have indicated the toxicity of dipeptide repea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fc74db9e29c624a44c8929c44242d0
http://europepmc.org/articles/PMC7903916