Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use

Autor: Raphaël Goutaudier, Fanny Joly, David Mallet, Magali Bartolomucci, Denis Guicherd, Carole Carcenac, Frédérique Vossier, Thibault Dufourd, Sabrina Boulet, Colin Deransart, Benoit Chovelon, Sebastien Carnicella

Publikováno v: Molecular Psychiatry. 28:463-474

The neurobiological mechanisms underlying compulsive alcohol use, a cardinal feature of alcohol use disorder, remain elusive. The key modulator of motivational processes, dopamine (DA), is suspected to play an important role in this pathology, but it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b570dac4293331df6d7acb462262677c
https://doi.org/10.1038/s41380-022-01848-5

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

Autor: Krzysztof Rogowski, Laurence Lafanechère, Christophe Bosc, Marie-Jo Moutin, Laurent Pelletier, Julien Le Friec, Eric Denarier, Pierre Heemeryck, Christian Delphin, Salahuddin Syed, Benoit Boulan, Frédérique Vossier, Annie Andrieux, Sandrine Humbert, Neri Amara, Yohann Couté, Matthew Bogyo, Juliette van Dijk, Chrystelle Aillaud, Leticia Peris, Laura E. Sanman, Anouk Bosson

Publikováno v: Science
Science, American Association for the Advancement of Science, 2017, 358 (6369), pp.1448-1453. ⟨10.1126/science.aao4165⟩
Science, 2017, 358 (6369), pp.1448-1453. ⟨10.1126/science.aao4165⟩

Tubulin carboxypeptidase identity revealed Enzymes of the α-tubulin detyrosination/tyrosination cycle create landmarks on microtubules that are essential for their multiple cellular functions and are altered in disease. Tubulin carboxypeptidases (TC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e5cac16dec3ca35974ccaa9f389c27
https://hal.archives-ouvertes.fr/hal-02345845